YRC Public Data Repository - Protein Structure Prediction

Protein:	Nca-PA, Nca-PB
Organism:	Drosophila melanogaster
Length:	190 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Nca-PA, Nca-PB.

Description	E-value	Query Range	Subject Range
gi\|109001730 - gi\|109001730\|ref\|XP_001098851.1\| PREDICTED: similar to Neuron-specific calcium-binding protein hippo...	183.0	[0..1]	[189..216]
gi\|114555708 - gi\|114555708\|ref\|XP_001155509.1\| PREDICTED: similar to Neuron specific calcium-binding protein P23K ...	180.0	[0..1]	[189..152]
gi\|73980372 - gi\|73980372\|ref\|XP_852217.1\| PREDICTED: similar to hippocalcin-like 1 [Canis familiaris]	179.0	[0..1]	[189..137]
gi\|50748592 - gi\|50748592\|ref\|XP_421316.1\| PREDICTED: similar to calmodulin 1; Calmodulin 1 (phosphorylase kinase,...	172.0	[0..18]	[174..514]
gi\|76668066 - gi\|76668066\|ref\|XP_609831.2\| PREDICTED: similar to Hippocalcin-like protein 4 (HLP4) [Bos taurus]	169.0	[0..1]	[188..284]
gi\|47221269 - gi\|47221269\|emb\|CAG13205.1\| unnamed protein product [Tetraodon nigroviridis]	164.0	[0..1]	[188..1]
gi\|108880132, gi... - gi\|157105260\|ref\|XP_001648788.1\| hippocalcin [Aedes aegypti], gi\|108880132\|gb\|EAT44357.1\| hippocalci... AGAP007247-PA, A... - Hippocalcin-like protein 1\|protein_coding\|2L:44619841:44628520:1\|gene:AGAP007247, Hippocalcin-like p... gi\|170043833, gi... - gi\|170043833\|ref\|XP_001849575.1\| hippocalcin [Culex quinquefasciatus], gi\|167867127\|gb\|EDS30510.1\| h... gi\|158285993, gi... - gi\|58376331\|ref\|XP_308553.2\| ENSANGP00000015900 [Anopheles gambiae str. PEST], gi\|55245634\|gb\|EAA041...	157.0	[0..1]	[188..1]
gi\|66513911 - gi\|66513911\|ref\|XP_392256.2\| PREDICTED: similar to Neurocalcin homolog (DrosNCa) [Apis mellifera]	157.0	[0..1]	[188..1]

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Predicted Domain #1

Region A:
Residues: [1-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKQNSKLKP EVLEDLKQNT EFTDAEIQEW YKGFLKDCPS GHLSVEEFKK IYGNFFPYGD  60
   61 ASKFAEHVFR TFDANGDGTI DFREFLCALS VTSRGKLEQK LKWAFSMYDL DGNGYISRQE 120
  121 MLEIVTAIYK MVGSVMKMPE DESTPEKRTD KIFRQMDRNK DGKLSLEEFI EGAKSDPSIV 180
  181 RLLQCDPQSH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.522879
Match:	1bjfA
Description:	Neurocalcin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.47426847861728	bayes_pls_golite062009
protein serine/threonine phosphatase activity	6.37104157544514	bayes_pls_golite062009
phosphatase activity	6.28157965296365	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.17799259119197	bayes_pls_golite062009
N-terminal myristoylation domain binding	5.746886320739	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	5.58369939851095	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.11186887221409	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase regulator activity	4.70715233640875	bayes_pls_golite062009
calcium ion binding	3.79609619542776	bayes_pls_golite062009
cytoskeletal protein binding	3.49668552859347	bayes_pls_golite062009
motor activity	3.25814691068414	bayes_pls_golite062009
binding	3.17556402087346	bayes_pls_golite062009
G-protein beta/gamma-subunit binding	3.05549386641848	bayes_pls_golite062009
structural constituent of muscle	2.75664690770084	bayes_pls_golite062009
metal ion binding	2.62077305565026	bayes_pls_golite062009
cation binding	2.62077305565026	bayes_pls_golite062009
ion binding	2.61312132078717	bayes_pls_golite062009
ion transmembrane transporter activity	2.57032504567157	bayes_pls_golite062009
cation transmembrane transporter activity	2.55650624542181	bayes_pls_golite062009
tubulin binding	2.51210014078446	bayes_pls_golite062009
actin binding	2.38676888633305	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.37465721152046	bayes_pls_golite062009
clathrin binding	2.36616108128297	bayes_pls_golite062009
protein binding	2.21291432166051	bayes_pls_golite062009
microtubule binding	2.17136406283012	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.99763594451773	bayes_pls_golite062009
transcription regulator activity	1.9739523190593	bayes_pls_golite062009
myosin II heavy chain binding	1.88775123370459	bayes_pls_golite062009
ER retention sequence binding	1.60111232562018	bayes_pls_golite062009
DNA binding	1.55722307354604	bayes_pls_golite062009
nucleic acid binding	1.53225451586959	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.51057181410195	bayes_pls_golite062009
kinase activity	1.48008348280256	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.34982153616582	bayes_pls_golite062009
myosin heavy chain binding	1.31753541231868	bayes_pls_golite062009
calcium-dependent protein kinase inhibitor activity	1.29632226581856	bayes_pls_golite062009
transporter activity	1.15928534291452	bayes_pls_golite062009
molecular transducer activity	1.11607939838219	bayes_pls_golite062009
signal transducer activity	1.11607939838219	bayes_pls_golite062009
microfilament motor activity	1.0725773039399	bayes_pls_golite062009
transferase activity	1.00143834284844	bayes_pls_golite062009
transmembrane transporter activity	0.945691505472547	bayes_pls_golite062009
phosphatase regulator activity	0.87149881541475	bayes_pls_golite062009
guanylate cyclase regulator activity	0.84389905735679	bayes_pls_golite062009
cyclase regulator activity	0.84389905735679	bayes_pls_golite062009
actin-dependent ATPase activity	0.83859958498483	bayes_pls_golite062009
actin filament binding	0.836375875773328	bayes_pls_golite062009
protein phosphatase regulator activity	0.822713961141111	bayes_pls_golite062009
cation channel activity	0.802117767859521	bayes_pls_golite062009
structural molecule activity	0.800850121197479	bayes_pls_golite062009
calcium channel regulator activity	0.7164851905066	bayes_pls_golite062009
substrate-specific transporter activity	0.693724160233023	bayes_pls_golite062009
transcription repressor activity	0.666488715029225	bayes_pls_golite062009
calcium sensitive guanylate cyclase activator activity	0.630360514213104	bayes_pls_golite062009
myosin binding	0.41761909113528	bayes_pls_golite062009
passive transmembrane transporter activity	0.386960491413065	bayes_pls_golite062009
channel activity	0.386960491413065	bayes_pls_golite062009
hydrolase activity	0.378268353045111	bayes_pls_golite062009
substrate-specific channel activity	0.362205423422174	bayes_pls_golite062009
	0.34446792626966	bayes_pls_golite062009
ion channel activity	0.343477643719352	bayes_pls_golite062009
channel regulator activity	0.32809521759917	bayes_pls_golite062009
voltage-gated channel activity	0.308919475701377	bayes_pls_golite062009
voltage-gated ion channel activity	0.304496519713588	bayes_pls_golite062009
voltage-gated cation channel activity	0.278054748078249	bayes_pls_golite062009
active transmembrane transporter activity	0.246383459363256	bayes_pls_golite062009
potassium channel activity	0.200283164564768	bayes_pls_golite062009
gated channel activity	0.150185445887481	bayes_pls_golite062009
structural constituent of cytoskeleton	0.116648335890738	bayes_pls_golite062009
voltage-gated potassium channel activity	0.109511951498555	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: