YRC Public Data Repository - Protein Structure Prediction

Protein:	FBpp0311562, FBp...
Organism:	Drosophila melanogaster
Length:	232 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0311562, FBp....

Description	E-value	Query Range	Subject Range
gi\|18417097, gi\|... - gi\|66354424\|gb\|AAY44849.1\| ubiquitinating enzyme [Arabidopsis thaliana], gi\|18417097\|ref\|NP_567791.1...	221.0	[0..86]	[231..31]
gi\|116487484, gi... - gi\|118404876\|ref\|NP_001072891.1\| ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog) [Xenopus (Silur... gi\|54311502, gi\|... - gi\|54311502\|gb\|AAH84849.1\| LOC495381 protein [Xenopus laevis], gi\|49899030\|gb\|AAH76728.1\| Ube2d2-pro...	220.0	[0..86]	[231..1]
UB2E2_MOUSE - Ubiquitin-conjugating enzyme E2 E2 OS=Mus musculus GN=Ube2e2 PE=2 SV=1	220.0	[0..32]	[232..1]
gi\|109066782 - gi\|109066782\|ref\|XP_001096263.1\| PREDICTED: similar to ubiquitin-conjugating enzyme E2D 4 (putative)... gi\|114613001, gi... - gi\|114613001\|ref\|XP_519070.2\| PREDICTED: ubiquitin-conjugating enzyme E2D 4 (putative) isoform 4 [Pa... UBE2D4 - ubiquitin-conjugating enzyme E2D 4 (putative)	220.0	[0..86]	[231..1]
gi\|109501290 - gi\|109501290\|ref\|XP_341289.3\| PREDICTED: similar to ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homol...	220.0	[0..30]	[232..23]
gi\|37590333, gi\|... - gi\|41152425\|ref\|NP_955958.1\| ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) [Danio rerio...	220.0	[0..86]	[231..1]
gi\|71027649 - gi\|71027649\|ref\|XP_763468.1\| ubiquitin-conjugating enzyme [Theileria parva strain Muguga] gi\|65303280 - gi\|65303280\|emb\|CAI75658.1\| ubiquitin-conjugating enzyme E2, putative [Theileria annulata] gi\|85000831 - gi\|85000831\|ref\|XP_955134.1\| ubiquitin-conjugating enzyme E2 [Theileria annulata strain Ankara] gi\|68350421 - gi\|68350421\|gb\|EAN31185.1\| ubiquitin-conjugating enzyme, putative [Theileria parva]	220.0	[0..86]	[232..1]
gi\|118403846, gi... - gi\|118403846\|ref\|NP_001072140.1\| UB2E2 [Sus scrofa], gi\|115371731\|gb\|ABI96190.1\| UB2E2 [Sus scrofa]	219.0	[0..32]	[232..1]

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Predicted Domain #1

Region A:
Residues: [1-82]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTPAAGSA AEVATSSATS NAPSAPSTTA SNVSNTSQPT TAGTPQARGG RGSNANGGAS  60
   61 GSNAGGGDEP RKEAKTTPRI SR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [83-232]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALGTSAKRIQ KELAEITLDP PPNCSAGPKG DNLYEWVSTI LGPPGSVYEG GVFFLDIHFS  60
   61 PEYPFKPPKV TFRTRIYHCN INSQGVICLD ILKDNWSPAL TISKVLLSIC SLLTDCNPAD 120
  121 PLVGSIATQY LQNREEHDRI ARLWTKRYAT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.09691
Match:	1y6lA
Description:	Human ubiquitin conjugating enzyme E2E2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	11.3486134076304	bayes_pls_golite062009
small conjugating protein ligase activity	11.2964721480824	bayes_pls_golite062009
acid-amino acid ligase activity	10.2401422444624	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	8.93602533934698	bayes_pls_golite062009
HLH domain binding	8.10904818707269	bayes_pls_golite062009
ligase activity	5.17219147802758	bayes_pls_golite062009
SUMO ligase activity	3.88357560284404	bayes_pls_golite062009
ISG15 ligase activity	3.37361650623694	bayes_pls_golite062009
NEDD8 ligase activity	3.30521803258995	bayes_pls_golite062009
transcription regulator activity	2.21355731489173	bayes_pls_golite062009
nucleic acid binding	2.13970605403492	bayes_pls_golite062009
DNA binding	1.95596447916631	bayes_pls_golite062009
protein binding	1.77678273247394	bayes_pls_golite062009
binding	1.75350658654805	bayes_pls_golite062009
transcription repressor activity	1.5236035191291	bayes_pls_golite062009
transcription activator activity	1.19240180311941	bayes_pls_golite062009
catalytic activity	0.891402822028799	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.58835335751383	bayes_pls_golite062009
kinase activity	0.519703305315987	bayes_pls_golite062009
protein kinase activity	0.443948654247666	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.373779304908933	bayes_pls_golite062009
small protein activating enzyme activity	0.36227294335656	bayes_pls_golite062009
protein serine/threonine kinase activity	0.182854082413338	bayes_pls_golite062009
transcription corepressor activity	0.122859425935324	bayes_pls_golite062009
transferase activity	0.0984525836903841	bayes_pls_golite062009
transcription factor binding	0.0104967529560147	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: