YRC Public Data Repository - Protein Structure Prediction

Protein:	FBpp0311562, FBp...
Organism:	Drosophila melanogaster
Length:	232 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0311562, FBp....

Description	E-value	Query Range	Subject Range
gi\|18417097, gi\|... - gi\|66354424\|gb\|AAY44849.1\| ubiquitinating enzyme [Arabidopsis thaliana], gi\|18417097\|ref\|NP_567791.1...	221.0	[0..86]	[231..31]
gi\|116487484, gi... - gi\|118404876\|ref\|NP_001072891.1\| ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog) [Xenopus (Silur... gi\|54311502, gi\|... - gi\|54311502\|gb\|AAH84849.1\| LOC495381 protein [Xenopus laevis], gi\|49899030\|gb\|AAH76728.1\| Ube2d2-pro...	220.0	[0..86]	[231..1]
UB2E2_MOUSE - Ubiquitin-conjugating enzyme E2 E2 OS=Mus musculus GN=Ube2e2 PE=2 SV=1	220.0	[0..32]	[232..1]
gi\|109066782 - gi\|109066782\|ref\|XP_001096263.1\| PREDICTED: similar to ubiquitin-conjugating enzyme E2D 4 (putative)... gi\|114613001, gi... - gi\|114613001\|ref\|XP_519070.2\| PREDICTED: ubiquitin-conjugating enzyme E2D 4 (putative) isoform 4 [Pa... UBE2D4 - ubiquitin-conjugating enzyme E2D 4 (putative)	220.0	[0..86]	[231..1]
gi\|109501290 - gi\|109501290\|ref\|XP_341289.3\| PREDICTED: similar to ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homol...	220.0	[0..30]	[232..23]
gi\|37590333, gi\|... - gi\|41152425\|ref\|NP_955958.1\| ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) [Danio rerio...	220.0	[0..86]	[231..1]
gi\|71027649 - gi\|71027649\|ref\|XP_763468.1\| ubiquitin-conjugating enzyme [Theileria parva strain Muguga] gi\|65303280 - gi\|65303280\|emb\|CAI75658.1\| ubiquitin-conjugating enzyme E2, putative [Theileria annulata] gi\|85000831 - gi\|85000831\|ref\|XP_955134.1\| ubiquitin-conjugating enzyme E2 [Theileria annulata strain Ankara] gi\|68350421 - gi\|68350421\|gb\|EAN31185.1\| ubiquitin-conjugating enzyme, putative [Theileria parva]	220.0	[0..86]	[232..1]
gi\|118403846, gi... - gi\|118403846\|ref\|NP_001072140.1\| UB2E2 [Sus scrofa], gi\|115371731\|gb\|ABI96190.1\| UB2E2 [Sus scrofa]	219.0	[0..32]	[232..1]

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Predicted Domain #1

Region A:
Residues: [1-82]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTPAAGSA AEVATSSATS NAPSAPSTTA SNVSNTSQPT TAGTPQARGG RGSNANGGAS  60
   61 GSNAGGGDEP RKEAKTTPRI SR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [83-232]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALGTSAKRIQ KELAEITLDP PPNCSAGPKG DNLYEWVSTI LGPPGSVYEG GVFFLDIHFS  60
   61 PEYPFKPPKV TFRTRIYHCN INSQGVICLD ILKDNWSPAL TISKVLLSIC SLLTDCNPAD 120
  121 PLVGSIATQY LQNREEHDRI ARLWTKRYAT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.09691
Match:	1y6lA
Description:	Human ubiquitin conjugating enzyme E2E2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	11.3486134076304	bayes_pls_golite062009
small conjugating protein ligase activity	11.2964721480824	bayes_pls_golite062009
acid-amino acid ligase activity	10.2401422444624	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	8.93602533934698	bayes_pls_golite062009
HLH domain binding	8.10904818707269	bayes_pls_golite062009
ligase activity	5.17219147802758	bayes_pls_golite062009
SUMO ligase activity	3.88357560284404	bayes_pls_golite062009
ISG15 ligase activity	3.37361650623694	bayes_pls_golite062009
NEDD8 ligase activity	3.30521803258995	bayes_pls_golite062009
transcription regulator activity	2.21355731489173	bayes_pls_golite062009
nucleic acid binding	2.13970605403492	bayes_pls_golite062009
DNA binding	1.95596447916631	bayes_pls_golite062009
protein binding	1.77678273247394	bayes_pls_golite062009
binding	1.75350658654805	bayes_pls_golite062009
transcription repressor activity	1.5236035191291	bayes_pls_golite062009
transcription activator activity	1.19240180311941	bayes_pls_golite062009
catalytic activity	0.891402822028799	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.58835335751383	bayes_pls_golite062009
kinase activity	0.519703305315987	bayes_pls_golite062009
protein kinase activity	0.443948654247666	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.373779304908933	bayes_pls_golite062009
small protein activating enzyme activity	0.36227294335656	bayes_pls_golite062009
protein serine/threonine kinase activity	0.182854082413338	bayes_pls_golite062009
transcription corepressor activity	0.122859425935324	bayes_pls_golite062009
transferase activity	0.0984525836903841	bayes_pls_golite062009
transcription factor binding	0.0104967529560147	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: