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View Structure Prediction Details

Protein: 1433Z_RAT
Organism: Rattus norvegicus
Length: 245 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for 1433Z_RAT.

Description E-value Query
Range
Subject
Range
gi|109087133 - gi|109087133|ref|XP_001098275.1| PREDICTED: similar to tyrosine 3/tryptophan 5 -monooxygenase activa...
456.0 [0..1] [245..334]
gi|68436321 - gi|68436321|ref|XP_699659.1| PREDICTED: similar to tyrosine 3-monooxygenase/tryptophan 5-monooxygena...
445.0 [0..1] [244..1532]
gi|114621209 - gi|114621209|ref|XP_528202.2| PREDICTED: similar to YWHAZ protein [Pan troglodytes]
435.0 [0..1] [245..138]
gi|30354619 - gi|30354619|gb|AAH51814.1| YWHAZ protein [Homo sapiens]
427.0 [0..1] [245..76]
gi|17017334 - gi|17017334|gb|AAL33624.1|AF440230_1 protein kinase A activity reporter 1 fusion protein [synthetic ...
414.0 [0..1] [234..232]
gi|76630316 - gi|76630316|ref|XP_874865.1| PREDICTED: similar to 14-3-3 protein theta (14-3-3 protein tau) (14-3-3...
403.0 [0..1] [226..165]
gi|7435027 - gi|7435027|pir||JC5384 14-3-3 zeta protein - mouse
399.0 [0..1] [245..1]

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Predicted Domain #1
Region A:
Residues: [1-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR  60
   61 VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL LEKFLIPNAS QPESKVFYLK 120
  121 MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE 180
  181 ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG 240
  241 EGGEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 112.0
Match: 2c1jA
Description: Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
tryptophan hydroxylase activator activity 9.05098057244127 bayes_pls_golite062009
protein kinase C inhibitor activity 5.16790132127192 bayes_pls_golite062009
cytoskeletal protein binding 3.42699469191586 bayes_pls_golite062009
actin binding 3.2102277095412 bayes_pls_golite062009
phosphoprotein phosphatase inhibitor activity 3.07610360813748 bayes_pls_golite062009
enzyme inhibitor activity 3.01719375125219 bayes_pls_golite062009
binding 2.865609797812 bayes_pls_golite062009
protein binding 2.70837661160137 bayes_pls_golite062009
phosphatase inhibitor activity 2.64873378059247 bayes_pls_golite062009
steroid hormone receptor binding 2.52034336284118 bayes_pls_golite062009
transcription regulator activity 2.47421036599568 bayes_pls_golite062009
protein serine/threonine kinase inhibitor activity 2.26190206574987 bayes_pls_golite062009
nucleic acid binding 2.24952329412422 bayes_pls_golite062009
protein kinase inhibitor activity 2.1605779239681 bayes_pls_golite062009
kinase inhibitor activity 2.13634503016902 bayes_pls_golite062009
DNA binding 2.12868741280915 bayes_pls_golite062009
enzyme regulator activity 2.06101279275497 bayes_pls_golite062009
receptor binding 1.90211144110648 bayes_pls_golite062009
protein kinase regulator activity 1.89095665930248 bayes_pls_golite062009
kinase regulator activity 1.83999438696779 bayes_pls_golite062009
nuclear hormone receptor binding 1.82791045779247 bayes_pls_golite062009
sequence-specific DNA binding 1.77196747521243 bayes_pls_golite062009
hormone receptor binding 1.75728917995967 bayes_pls_golite062009
transcription repressor activity 1.58823136201189 bayes_pls_golite062009
transcription activator activity 1.55295513057402 bayes_pls_golite062009
enzyme binding 0.97087555033584 bayes_pls_golite062009
transcription factor binding 0.644366120007212 bayes_pls_golite062009
protein domain specific binding 0.549856334651464 bayes_pls_golite062009
transcription corepressor activity 0.493085020732158 bayes_pls_golite062009
catalytic activity 0.260308151913118 bayes_pls_golite062009
glucocorticoid receptor binding 0.201948675373558 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.115610219048892 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle