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View Structure Prediction Details

Protein: Dscam-PAA
Organism: Drosophila melanogaster
Length: 2016 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PAA.

Description E-value Query
Range
Subject
Range
Dscam-PAM - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
1537.0 [0..3] [2016..3]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.39794
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [139-817]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYYEAEVVSE YVIRGNTAVL KCTIPSFVAD FLRVEAWVAS DGTEYAPEED FDGKYLVLPS  60
   61 GELHIREVGP EDGYKSYQCR TKHRLTGETR LSATKGRLVI TEPVGSVGPK VEIKDKVGIF 120
  121 VAKSNSSLAL LCPAQSYPIP AFRWYKFIEG TTRKQAVVLN DRVKQVSGTL IIKDAVVEDS 180
  181 GKYLCVVNNS VGGESVETVL TVTAPLSAKI DPPTQTVDFG RPAVFTCQYT GNPIKTVSWM 240
  241 KDGKAIGHSE PVLRIESVKK EDKGMYQCFV RNDQESAEAS AELKLGGRFD PPVIRQAFQE 300
  301 ETMEPGPSVF LKCVAGGNPT PEISWELDGK KIANNDRYQV GQYVTVNGDV VSYLNITSVH 360
  361 ANDGGLYKCI AKSKVGVAEH SAKLNVYGLP YIRQMEKKAI VAGETLIVTC PVAGYPIDSI 420
  421 VWERDNRALP INRKQKVFPN GTLIIENVER NSDQATYTCV AKNQEGYSAR GSLEVQVMVL 480
  481 PQIVPFDFGE ETVNELDMVS ASCTVNKGDL PIDVAWTKNG GRVYTNDGIV VTKTSTRMSV 540
  541 LSIESARARH AGNYSCVATN NAGETRQWAV LAVNVPPRWI LEPTDKAFAQ GSDAKVECKA 600
  601 DGFPKPQVTW KKAVGDTPGE YKDLKKSDNI RVEEGTLHVD NIQKTNEGYY LCEAINGIGS 660
  661 GLSAVIMISV QAPPEFTEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.045757
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [818-847]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRNQTARRGE PAVLQCEAKG EKPIGILWNM 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.69897
Match: 2cryA
Description: Solution structure of the fifth ig-like domain of human kin of IRRE like 3
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [848-1375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNMRLDPKND NRYTIREEIL STGVMSSLSI KRTERSDSAL FTCVATNAFG SDDASINMIV  60
   61 QEVPEMPYAL KVLDKSGRSV QLSWAQPYDG NSPLDRYIIE FKRSRASWSE IDRVIVPGHT 120
  121 TEAQVQKLSP ATTYNIRIVA ENAIGTSQSS EAVTIITAEE APSGKPQNIK VEPVNQTTMR 180
  181 VTWKPPPRTE WNGEILGYYV GYKLSNTNSS YVFETINFIT EEGKEHNLEL QNLRVYTQYS 240
  241 VVIQAFNKIG AGPLSEEEKQ FTAEGTPSQP PSDTACTTLT SQTIRVGWVS PPLESANGVI 300
  301 KTYKVVYAPS DEWYDETKRH YKKTASSDTV LHGLKKYTNY TMQVLATTAG GDGVRSVPIH 360
  361 CQTEPDVPEA PTDVKALVMG NAAILVSWRP PAQPNGIITQ YTVYSKAEGA ETETKTQKVP 420
  421 HYQMSFEATE LEKNKPYEFW VTASTTIGEG QQSKSIVAMP SDQVPAKIAS FDDTFTATFK 480
  481 EDAKMPCLAV GAPQPEITWK IKGVEFSAND RMRVLPDGSL LIKSVNRQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.0
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #5
Region A:
Residues: [1376-1592]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAGDYSCHAE NSIAKDSITH KLIVLAPPQS PHVTLSATTT DALTVKLKPH EGDTAPLHGY  60
   61 TLHYKPEFGE WETSEVSVDS QKHNIEGLLC GSRYQVYATG FNNIGAGEAS DILNTRTKGQ 120
  121 KPKLPEKPRF IEVSSNSVSL HFKAWKDGGC PMSHFVVESK KRDQIEWNQI SNNVKPDNNY 180
  181 VVLDLEPATW YNLRITAHNS AGFTVAEYDF ATLTVTG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.0
Match: 1fnhA
Description: Fibronectin, different Fn3 modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 5.81747667416248 bayes_pls_golite062009
structural constituent of muscle 5.71979489668015 bayes_pls_golite062009
transmembrane receptor activity 4.81256300373074 bayes_pls_golite062009
ankyrin binding 4.69755754047169 bayes_pls_golite062009
receptor activity 4.66147271961356 bayes_pls_golite062009
alpha-actinin binding 4.57951951779666 bayes_pls_golite062009
actinin binding 4.57900103206288 bayes_pls_golite062009
cytokine binding 4.43581512268554 bayes_pls_golite062009
cytokine receptor activity 4.08668869714207 bayes_pls_golite062009
growth factor binding 4.06808996928726 bayes_pls_golite062009
molecular transducer activity 3.69234048247377 bayes_pls_golite062009
signal transducer activity 3.69234048247377 bayes_pls_golite062009
extracellular matrix structural constituent 3.5949595622742 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
receptor binding 2.38673889309915 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
peptide hormone binding 2.12033076929638 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
prolactin receptor activity 1.9556649101819 bayes_pls_golite062009
mercury ion binding 1.85843060232985 bayes_pls_golite062009
cytoskeletal protein binding 1.85720106085239 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
glycosaminoglycan binding 1.56410665522466 bayes_pls_golite062009
myosin light chain kinase activity 1.49217960276915 bayes_pls_golite062009
protein kinase activity 1.42856560840953 bayes_pls_golite062009
nucleic acid binding 1.32813363771214 bayes_pls_golite062009
transcription regulator activity 1.31663344632755 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 1.27192437373177 bayes_pls_golite062009
actin binding 1.21472460452555 bayes_pls_golite062009
DNA binding 1.2006039770643 bayes_pls_golite062009
cytokine activity 1.18680139050127 bayes_pls_golite062009
growth hormone receptor activity 1.15929762138929 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.15899955607967 bayes_pls_golite062009
heparin binding 1.15000556789505 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.12142142875217 bayes_pls_golite062009
kinase activity 1.11027658115625 bayes_pls_golite062009
structural molecule activity 0.94240190391222 bayes_pls_golite062009
protease binding 0.942107032692451 bayes_pls_golite062009
peptide binding 0.92031154055894 bayes_pls_golite062009
interleukin-6 binding 0.888638861691021 bayes_pls_golite062009
interleukin-6 receptor activity 0.888638861691021 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
cell surface binding 0.630081242528945 bayes_pls_golite062009
oncostatin-M receptor activity 0.628488391922279 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.628488391922279 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
collagen binding 0.593745877718282 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transcription factor activity 0.557290274937694 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
polysaccharide binding 0.54737137289904 bayes_pls_golite062009
hormone binding 0.49524185948356 bayes_pls_golite062009
cytokine receptor binding 0.47107517390107 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
growth factor activity 0.432629984792427 bayes_pls_golite062009
structural constituent of cytoskeleton 0.40600177052491 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
pattern binding 0.31156427047296 bayes_pls_golite062009
interleukin-7 binding 0.301052531308189 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
transcription activator activity 0.135753557343301 bayes_pls_golite062009
actin filament binding 0.135484838710405 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
transcription factor binding 0.075900818564989 bayes_pls_golite062009
interleukin-11 receptor activity 0.0423783987133706 bayes_pls_golite062009
interleukin-11 binding 0.0423783987133706 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1593-1805]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTIAPSRDLP ELSAEDTIRI ILSNLNLVVP VVAALLVIII AIIVICILRS KGNHHKDDVV  60
   61 YNQTMGPGAT LDKRRPDLRD ELGYIAPPNR KLPPVPGSNY NTCDRIKRGR GGLRSNHSTW 120
  121 DPRRNPNLYE ELKAPPVPMH GNHYGHAHGN AECHYRHPGM EDEICPYATF HLLGFREEMD 180
  181 PTKAMNFQTF PHQNGHAGPV PGHAGTMLPP GHP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1806-2016]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHVHSRSGSQ SMPRANRYQR KNSQGGQSSI YTPAPEYDDP ANCAEEDQYR RYTRVNSQGG  60
   61 SLYSGPGPEY DDPANCAPEE DQYGSQYGGP YGQPYDHYGS RGSMGRRSIG SARNPGNGSP 120
  121 EPPPPPPRNH DMSNSSFNDS KESNEISEAE CDRDHGPRGN YGAVKRSPQP KDQRTTEEMR 180
  181 KLIERNETGP KQLQLQQANG AGFTAYDTMA V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle