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View Structure Prediction Details

Protein: gi|113193588, gi...
Organism: Drosophila melanogaster
Length: 1475 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|113193588, gi....

Description E-value Query
Range
Subject
Range
rdgA-PA - The gene retinal degeneration A is referred to in FlyBase by the symbol Dmel\rdgA (CG42667, FBgn0261...
1602.0 [0..1] [1464..1]

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Predicted Domain #1
Region A:
Residues: [1-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQQQQPSID QLPEPTASTS NSATTKPTIA TATTSTTTTS GNNFHQQLQA TTAATMQRLR  60
   61 TTFTRSRTPT GAEMKMQNSL EVPKQVRSAS FDEMQLESQR ASSSLLKQQS SSSASADERS 120
  121 SEAGFLQVPL AAHQQRSHSF DSATASAGSD DSGTFLEVPR RLKARRSSST KTPPPCIHCH 180
  181 YLEEYERRMT AEQRYFIDHR ELTALSYSNT SSEASEDE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [219-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEVEGHNAEE EEEGSAAIED AEEETTEAAT EEADEDPRTE VESEHDHDPD DDAALEMDIR  60
   61 IGNMSQGSSI EESRARLPRQ MRRHTIGSSS VTSASEDEGL EGSDNGSPHF GNTLLPPQPT 120
  121 TPCGITFTLS PTNGDYPSPP HLPLDPGSPP ISPCSSNSGR LPALAPIIST PCSSADADDA 180
  181 GAAMGLPVRA RRRSISRQEA IFVEPTGNSL ENVSHEEV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [437-553]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNSNTKSSVD TADSLDEAST MATCGSPGAA GGSGASSSHH NAFVVRDIYL MVPDLKRDRA  60
   61 ASVDSCFSKL SSNAKTEELQ PSADGCFLTV PNINATRSRS VDIVLPTDEQ ARYKALS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1tuzA
Description: NMR Structure of the Diacylglycerol kinase alpha, NESGC target HR532
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [554-724]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGSTVTYAD GRTASASNSR RPIRIVPDWT ENAVQGEHYW KPTSASGDLC CLNEECIKSG  60
   61 QRMKCSACQL VAHHNCIPFV NEKSTLACKP TYRDVGIRQY REQTTTHHHW VHRKLEKGKC 120
  121 KQCGKFFPMK QAVQSKLFGS KEIVALACAW CHEIYHNKEA CFNQAKIGEE C

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.522879
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #5
Region A:
Residues: [725-849]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLGNYAPIIV PPSWIVKLPT KGNFKSSIRV SNKNNAASGS GGGGAGGGAG GGGGKSKKQT  60
   61 QRRQKGKEEK KEPRAFIVKP IPSPEVIPVI VFINPKSGGN QGHKLLGKFQ HLLNPRQVFD 120
  121 LTQGG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [850-936]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKMGLDMFRK APNLRVLACG GDGTVGWVLS VLDQIQPPLQ PAPAVGVLPL GTGNDLARAL  60
   61 GWGGGYTDEP IGKILREIGM SQCVLMD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 2jgrA
Description: No description for 2jgrA was found.

Predicted Domain #7
Region A:
Residues: [937-1071]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RWRVKVTPND DVTDDHVDRS KPNVPLNVIN NYFSFGVDAH IALEFHEARE AHPERFNSRL  60
   61 RNKMYYGQMG GKDLILRQYR NLSQWVTLEC DGQDFTGKLR DAGCHAVLFL NIPSYGGGTH 120
  121 PWNDSFGASK PSIDD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.1
Match: 2bonA
Description: No description for 2bonA was found.

Predicted Domain #8
Region A:
Residues: [1072-1475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLMEVVGLTT YQLPMLQAGM HGTCICQCRK ARIITKRTIP MQVDGEACRV KPSVIEIELL  60
   61 NKALMLSKRK HGRGDVQVNP LEKMQLHILR VTMQQYEQYH YDKEMLRKLA NKLGQIEIES 120
  121 QCDLEHVRNM LNTKFEESIS YPKVSQDWCF IDSCTAEHYF RIDRAQEHLH YICDIAIDEL 180
  181 YILDHEAATM PQTPDQERSF AAFSQRQAQN ERRQMDQAQG RGPGSTDEDL QIGSKPIKVM 240
  241 KWKSNKDRLF SFNEDVFGCG FSPILEQTSD AILLAAQSGD LNMLRALHEQ GYSLQSVNKN 300
  301 GQTALHFACK YNHRDIVKYI IASATRRLIN MADKELGQTA LHIAAEQNRR DICVMLVAAG 360
  361 AHLDTLDSGG NTPMMVAFNK NANEIATYLE SQERFMHLEK QTRI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.69897
Match: 1n11A
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.60916417202222 bayes_pls_golite062009
molecular transducer activity 1.2375987667709 bayes_pls_golite062009
signal transducer activity 1.2375987667709 bayes_pls_golite062009
receptor activity 1.22857731988464 bayes_pls_golite062009
cytoskeletal protein binding 1.1034434071611 bayes_pls_golite062009
transmembrane receptor activity 1.10325771560525 bayes_pls_golite062009
kinase activity 0.973206891506661 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.954469238725827 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.876784788207113 bayes_pls_golite062009
transcription factor binding 0.84590123339816 bayes_pls_golite062009
substrate-specific channel activity 0.74360198348535 bayes_pls_golite062009
protein kinase activity 0.663511836722598 bayes_pls_golite062009
enzyme binding 0.60140077251711 bayes_pls_golite062009
transcription regulator activity 0.589753112911856 bayes_pls_golite062009
passive transmembrane transporter activity 0.556885542399749 bayes_pls_golite062009
channel activity 0.556885542399749 bayes_pls_golite062009
enzyme regulator activity 0.5337972579854 bayes_pls_golite062009
ion channel activity 0.40517082975613 bayes_pls_golite062009
structural constituent of cytoskeleton 0.3210142108162 bayes_pls_golite062009
transferase activity 0.298084176742023 bayes_pls_golite062009
transcription activator activity 0.295016294965448 bayes_pls_golite062009
gated channel activity 0.28982824879439 bayes_pls_golite062009
cation channel activity 0.2321216453051 bayes_pls_golite062009
DNA binding 0.139886855398905 bayes_pls_golite062009
transcription repressor activity 0.108244697820437 bayes_pls_golite062009
nucleic acid binding 0.106792084948545 bayes_pls_golite062009
mechanically gated channel activity 0.0507470076143287 bayes_pls_golite062009
mechanically-gated ion channel activity 0.0507470076143287 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.0018080615624233 bayes_pls_golite062009
actin binding 6.04689889151855E-4 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle