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View Structure Prediction Details

Protein: AMBP
Organism: Homo sapiens
Length: 352 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AMBP.

Description E-value Query
Range
Subject
Range
gi|73971996 - gi|73971996|ref|XP_538807.2| PREDICTED: similar to AMBP protein precursor [Canis familiaris]
1.0E-78 [1..349] [67..415]
AMBP_MOUSE - AMBP protein precursor [Contains: Alpha-1-microglobulin; Inter-alpha-trypsin inhibitor light chain -...
2.0E-74 [1..350] [1..349]
gi|247163 - gi|247163|gb|AAB21782.1| polyprotein 1-microglobulin/bikunin [Rattus sp.]
AMBP_RAT - Protein AMBP OS=Rattus norvegicus GN=Ambp PE=1 SV=1
3.0E-74 [1..350] [1..349]
gi|197102775 - gi|197102775|ref|NP_001127069.1| alpha-1-microglobulin/bikunin precursor [Pongo abelii]
gi|56403596 - gi|56403596|emb|CAI29600.1| hypothetical protein [Pongo abelii]
8.0E-74 [17..352] [17..352]
gi|114626320 - gi|114626320|ref|XP_001155186.1| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes]
3.0E-73 [17..352] [17..352]
AMBP_BOVIN - Protein AMBP OS=Bos taurus GN=AMBP PE=1 SV=2
2.0E-72 [12..352] [12..352]
gi|11380475 - pir||TIPGBI alpha-1-microglobulin/inter-alpha-trypsin inhibitor precursor - pig (fragment)
AMBP_PIG - Protein AMBP (Fragment) OS=Sus scrofa GN=AMBP PE=1 SV=2
2.0E-72 [16..352] [1..337]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSLGALLLL LSACLAVSAG PVPTPPDNIQ VQENFNISRI YGKWYNLAIG STCPWLKKIM  60
   61 DRMTVSTLVL GEGATEAEIS MTSTRWRKGV CEETSGAYEK TDTDGKFLYH KSKWNITMES 120
  121 YVVHTNYDEY AIFLTKKFSR HHGPTITAKL YGRAPQLRET LLQDFRVVAQ GVGIPEDSIF 180
  181 TMADRGECVP GEQEPEPILI PR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 2a2gA
Description: Major urinary protein/alpha-2u-globulin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
prostaglandin-D synthase activity 9.38894954257204 bayes_pls_golite062009
retinoid binding 8.02429867979822 bayes_pls_golite062009
isoprenoid binding 7.89008407234188 bayes_pls_golite062009
binding 2.50897150695844 bayes_pls_golite062009
transporter activity 2.15627660314839 bayes_pls_golite062009
lipid binding 0.936781587098929 bayes_pls_golite062009
fatty acid binding 0.761923641769607 bayes_pls_golite062009
substrate-specific transporter activity 0.670647472301401 bayes_pls_golite062009
intramolecular oxidoreductase activity 0.55704304940148 bayes_pls_golite062009
transcription regulator activity 0.195428524962032 bayes_pls_golite062009
protein binding 0.184047030127727 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [203-352]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRRAVLPQEE EGSGGGQLVT EVTKKEDSCQ LGYSAGPCMG MTSRYFYNGT SMACETFQYG  60
   61 GCMGNGNNFV TEKECLQTCR TVAACNLPIV RGPCRAFIQL WAFDAVKGKC VLFPYGGCQG 120
  121 NGNKFYSEKE CREYCGVPGD GDEELLRFSN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.30103
Match: 1bikA
Description: X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
immunoglobulin binding 2.21250149631569 bayes_pls_golite062009
serine-type endopeptidase inhibitor activity 2.15113274690464 bayes_pls_golite062009
calcium oxalate binding 1.85768982003861 bayes_pls_golite062009
peptidase inhibitor activity 1.69798619068558 bayes_pls_golite062009
enzyme inhibitor activity 1.60627942329037 bayes_pls_golite062009
binding 1.41033344387938 bayes_pls_golite062009
endopeptidase inhibitor activity 1.28133863203743 bayes_pls_golite062009
enzyme regulator activity 1.01679462784039 bayes_pls_golite062009
protein complex binding 0.96930864775065 bayes_pls_golite062009
protein binding 0.692126101154498 bayes_pls_golite062009
extracellular matrix structural constituent 0.6437942969485 bayes_pls_golite062009
heme binding 0.541048450973279 bayes_pls_golite062009
tetrapyrrole binding 0.541048450973279 bayes_pls_golite062009
protein dimerization activity 0.22768126406072 bayes_pls_golite062009
iron ion binding 0.108644734111329 bayes_pls_golite062009
protein homodimerization activity 0.0683298934283131 bayes_pls_golite062009
IgA binding 0.0633095729038504 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle