YRC Public Data Repository - Protein Structure Prediction

Protein:	SIRT2
Organism:	Homo sapiens
Length:	389 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIRT2.

Description	E-value	Query Range	Subject Range
SIR2_MOUSE - NAD-dependent protein deacetylase sirtuin-2 OS=Mus musculus GN=Sirt2 PE=1 SV=2	0.0	[1..389]	[1..389]
SIR2_MACFA - NAD-dependent protein deacetylase sirtuin-2 OS=Macaca fascicularis GN=SIRT2 PE=2 SV=1	0.0	[1..389]	[1..389]
gi\|165377268, gi... - gi\|76641425\|ref\|XP_580596.2\| PREDICTED: similar to NAD-dependent deacetylase sirtuin-2 (SIR2-like pr...	0.0	[1..389]	[1..390]
gi\|114677035, gi... - gi\|114677041\|ref\|XP_001168346.1\| PREDICTED: sirtuin 2 isoform 7 [Pan troglodytes], gi\|114677039\|ref\|... SIR2_PONAB - NAD-dependent protein deacetylase sirtuin-2 OS=Pongo abelii GN=SIRT2 PE=2 SV=1 SIRT2_PONPY - NAD-dependent deacetylase sirtuin-2 - Pongo pygmaeus (Orangutan) gi\|158254868, gi... - gi\|5668596\|gb\|AAD45971.1\|AF095714_1 silencing information regulator 2-like protein [Homo sapiens], g... SIRT2_RAT, SIR2_RAT - (Q924Y7) NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2), (Q924Y7) NAD-depend... gi\|224487801, gi... - gi\|224487801\|dbj\|BAH24135.1\| sirtuin (silent mating type information regulation 2 homolog) 2 [synthe...	0.0	[38..389]	[1..352]
SIR2_RAT - NAD-dependent protein deacetylase sirtuin-2 OS=Rattus norvegicus GN=Sirt2 PE=1 SV=1	0.0	[38..387]	[1..349]

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Predicted Domain #1

Region A:
Residues: [1-389]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEPDPSHPL ETQAGKVQEA QDSDSDSEGG AAGGEADMDF LRNLFSQTLS LGSQKERLLD  60
   61 ELTLEGVARY MQSERCRRVI CLVGAGISTS AGIPDFRSPS TGLYDNLEKY HLPYPEAIFE 120
  121 ISYFKKHPEP FFALAKELYP GQFKPTICHY FMRLLKDKGL LLRCYTQNID TLERIAGLEQ 180
  181 EDLVEAHGTF YTSHCVSASC RHEYPLSWMK EKIFSEVTPK CEDCQSLVKP DIVFFGESLP 240
  241 ARFFSCMQSD FLKVDLLLVM GTSLQVQPFA SLISKAPLST PRLLINKEKA GQSDPFLGMI 300
  301 MGLGGGMDFD SKKAYRDVAW LGECDQGCLA LAELLGWKKE LEDLVRREHA SIDAQSGAGV 360
  361 PNPSTSASPK KSPPPAKDEA RTTEREKPQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	105.0
Match:	1j8fA
Description:	Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	9.15022242957651	bayes_pls_golite062009
histone deacetylase activity	9.04876491350231	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	8.13038616303736	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	8.13038616303736	bayes_pls_golite062009
deacetylase activity	8.11496387956068	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	5.83127897351395	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K9 specific)	5.29340754009793	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K14 specific)	5.29340754009793	bayes_pls_golite062009
tubulin deacetylase activity	4.98963898611597	bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity	4.62921662347995	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H4-K16 specific)	3.89088174584308	bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific)	3.4896257195243	bayes_pls_golite062009
transcription regulator activity	2.9155913558118	bayes_pls_golite062009
DNA binding	2.43141001866996	bayes_pls_golite062009
nucleic acid binding	2.41433477472968	bayes_pls_golite062009
transcription repressor activity	2.24657784428979	bayes_pls_golite062009
binding	2.06552694538163	bayes_pls_golite062009
histone binding	1.71445510915336	bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific)	1.70314558948153	bayes_pls_golite062009
transcription corepressor activity	1.64212790017753	bayes_pls_golite062009
protein binding	1.52593340148652	bayes_pls_golite062009
nucleosome binding	1.5125174755597	bayes_pls_golite062009
hydrolase activity	1.43067365161346	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.40719303660557	bayes_pls_golite062009
transcription factor activity	1.30143289828088	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.26370407179255	bayes_pls_golite062009
transcription factor binding	1.14766678956419	bayes_pls_golite062009
NAD(P)+-protein-arginine ADP-ribosyltransferase activity	0.963519974868694	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.74741958699764	bayes_pls_golite062009
catalytic activity	0.739210399081789	bayes_pls_golite062009
cation transmembrane transporter activity	0.56434127203174	bayes_pls_golite062009
transcription cofactor activity	0.54005617175343	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.114062221123972	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: