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Protein Overview: SIRT2

General Information:
Name(s) found: SIRT2 [HGNC (HUGO)]
Description(s) found:
Found 34 descriptions.
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  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 389 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEPDPSHPL ETQAGKVQEA QDSDSDSEGG AAGGEADMDF LRNLFSQTLS LGSQKERLLD  60
   61 ELTLEGVARY MQSERCRRVI CLVGAGISTS AGIPDFRSPS TGLYDNLEKY HLPYPEAIFE 120
  121 ISYFKKHPEP FFALAKELYP GQFKPTICHY FMRLLKDKGL LLRCYTQNID TLERIAGLEQ 180
  181 EDLVEAHGTF YTSHCVSASC RHEYPLSWMK EKIFSEVTPK CEDCQSLVKP DIVFFGESLP 240
  241 ARFFSCMQSD FLKVDLLLVM GTSLQVQPFA SLISKAPLST PRLLINKEKA GQSDPFLGMI 300
  301 MGLGGGMDFD SKKAYRDVAW LGECDQGCLA LAELLGWKKE LEDLVRREHA SIDAQSGAGV 360
  361 PNPSTSASPK KSPPPAKDEA RTTEREKPQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..389] PSI-BLAST 105.0 Sirt2 histone deacetylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  9.15022242957651 bayes_pls_golite062009
  • histone deacetylase activity
    		•  9.04876491350231 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • deacetylase activity
    		•  8.11496387956068 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.83127897351395 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  4.98963898611597 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  4.62921662347995 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  3.89088174584308 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.4896257195243 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • histone binding
    		•  1.71445510915336 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  1.70314558948153 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • protein binding
    		•  1.52593340148652 bayes_pls_golite062009
  • nucleosome binding
    		•  1.5125174755597 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43067365161346 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.40719303660557 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.26370407179255 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity
    		•  0.963519974868694 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.74741958699764 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.56434127203174 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle