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View Structure Prediction Details

Protein: gi|468497, gi|21...
Organism: Homo sapiens
Length: 419 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|468497, gi|21....

Description E-value Query
Range
Subject
Range
gi|50979188, gi|... - gi|50979188|ref|NP_001003337.1| microphthalmia-associated transcription factor [Canis lupus familiar...
8.0E-99 [1..419] [1..419]
gi|396740, gi|80... - gi|80474761|gb|AAI08977.1| Microphthalmia-associated transcription factor [Mus musculus], gi|6678884...
5.0E-97 [1..419] [1..419]
gi|149036812, gi... - gi|149036812|gb|EDL91430.1| rCG56390 [Rattus norvegicus], gi|109472393|ref|XP_001065525.1| PREDICTED...
3.0E-96 [1..419] [1..419]
gi|20338777 - gi|20338777|emb|CAD30262.1| microphthalmia-associated transcription factor [Mesocricetus auratus]
3.0E-94 [1..419] [1..413]
gi|114587816 - gi|114587816|ref|XP_001138431.1| PREDICTED: microphthalmia-associated transcription factor isoform 4...
8.0E-94 [1..419] [1..419]
gi|1092105 - gi|1092105|prf||2022321A transcription factor
1.0E-92 [1..419] [1..419]
gi|6714634 - gi|6714634|dbj|BAA89536.1| Mi [Coturnix coturnix]
4.0E-91 [11..419] [66..474]
gi|7688653 - gi|7688653|gb|AAF67467.1|AF145751_1 microphthalmia protein [Gallus gallus]
8.0E-91 [1..419] [1..385]

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Predicted Domain #1
Region A:
Residues: [1-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEMLEYNHY QVQTHLENPT KYHIQQAQRQ QVKQYLSTTL ANKHANQVLS LPCPNQPGDH  60
   61 VMPPVPGSSA PNSPMAMLTL NSNCEKEGFY KFEEQNRAES ECPGMNTHSR ASCMQMDDVI 120
  121 DDIISLESSY NEEILGLMDP ALQMANTLPV SGNLIDLYGN QGLPPPGLTI SNSCPANLPN 180
  181 IKRELTACIF PTESEARA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [199-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAKERQKKDN HNLIERRRRF NINDRIKELG TLIPKSNDPD MRWNKGTILK ASVDYIRKLQ  60
   61 REQQRAKELE NRQKKLEHAN RHLLLRIQEL EMQARAHGLS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
promoter binding 1.56457725225443 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
transcription coactivator activity 1.39260472877067 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
structure-specific DNA binding 0.3655541712365 bayes_pls_golite062009
double-stranded DNA binding 0.29436315000437 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [299-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIPSTGLCSP DLVNRIIKQE PVLENCSQDL LQHHADLTCT TTLDLTDGTI TFNNNLGTGT  60
   61 EANQAYSVPT KMGSKLEDIL MDDTLSPVGV TDPLLSSVSP GASKTSSRRS SMSMEETEHT 120
  121 C

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle