YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|468497, gi\|21...
Organism:	Homo sapiens
Length:	419 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|468497, gi|21....

Description	E-value	Query Range	Subject Range
gi\|50979188, gi\|... - gi\|50979188\|ref\|NP_001003337.1\| microphthalmia-associated transcription factor [Canis lupus familiar...	8.0E-99	[1..419]	[1..419]
gi\|396740, gi\|80... - gi\|80474761\|gb\|AAI08977.1\| Microphthalmia-associated transcription factor [Mus musculus], gi\|6678884...	5.0E-97	[1..419]	[1..419]
gi\|149036812, gi... - gi\|149036812\|gb\|EDL91430.1\| rCG56390 [Rattus norvegicus], gi\|109472393\|ref\|XP_001065525.1\| PREDICTED...	3.0E-96	[1..419]	[1..419]
gi\|20338777 - gi\|20338777\|emb\|CAD30262.1\| microphthalmia-associated transcription factor [Mesocricetus auratus]	3.0E-94	[1..419]	[1..413]
gi\|114587816 - gi\|114587816\|ref\|XP_001138431.1\| PREDICTED: microphthalmia-associated transcription factor isoform 4...	8.0E-94	[1..419]	[1..419]
gi\|1092105 - gi\|1092105\|prf\|\|2022321A transcription factor	1.0E-92	[1..419]	[1..419]
gi\|6714634 - gi\|6714634\|dbj\|BAA89536.1\| Mi [Coturnix coturnix]	4.0E-91	[11..419]	[66..474]
gi\|7688653 - gi\|7688653\|gb\|AAF67467.1\|AF145751_1 microphthalmia protein [Gallus gallus]	8.0E-91	[1..419]	[1..385]

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Predicted Domain #1

Region A:
Residues: [1-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEMLEYNHY QVQTHLENPT KYHIQQAQRQ QVKQYLSTTL ANKHANQVLS LPCPNQPGDH  60
   61 VMPPVPGSSA PNSPMAMLTL NSNCEKEGFY KFEEQNRAES ECPGMNTHSR ASCMQMDDVI 120
  121 DDIISLESSY NEEILGLMDP ALQMANTLPV SGNLIDLYGN QGLPPPGLTI SNSCPANLPN 180
  181 IKRELTACIF PTESEARA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.247	N/A	N/A	a.74.1	Cyclin-like
View	Download	0.231	N/A	N/A	a.1.1	Globin-like

Predicted Domain #2

Region A:
Residues: [199-298]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAKERQKKDN HNLIERRRRF NINDRIKELG TLIPKSNDPD MRWNKGTILK ASVDYIRKLQ  60
   61 REQQRAKELE NRQKKLEHAN RHLLLRIQEL EMQARAHGLS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.522879
Match:	1nkpA
Description:	Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	5.38658950816179	bayes_pls_golite062009
DNA binding	5.18654839258297	bayes_pls_golite062009
nucleic acid binding	5.05768805749761	bayes_pls_golite062009
transcription factor activity	4.78039531631248	bayes_pls_golite062009
transcription activator activity	3.87875547821718	bayes_pls_golite062009
binding	3.81829206350975	bayes_pls_golite062009
sequence-specific DNA binding	3.42035985454056	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.39500382187264	bayes_pls_golite062009
protein binding	2.64975291677725	bayes_pls_golite062009
transcription factor binding	2.61163564741984	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	2.42306484786159	bayes_pls_golite062009
promoter binding	1.56457725225443	bayes_pls_golite062009
transcription cofactor activity	1.52770895937238	bayes_pls_golite062009
transcription coactivator activity	1.39260472877067	bayes_pls_golite062009
transcription repressor activity	0.955588849035129	bayes_pls_golite062009
transcription corepressor activity	0.801830750183111	bayes_pls_golite062009
protein heterodimerization activity	0.53175615551166	bayes_pls_golite062009
structure-specific DNA binding	0.3655541712365	bayes_pls_golite062009
double-stranded DNA binding	0.29436315000437	bayes_pls_golite062009
protein dimerization activity	0.20674648626116	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [299-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIPSTGLCSP DLVNRIIKQE PVLENCSQDL LQHHADLTCT TTLDLTDGTI TFNNNLGTGT  60
   61 EANQAYSVPT KMGSKLEDIL MDDTLSPVGV TDPLLSSVSP GASKTSSRRS SMSMEETEHT 120
  121 C

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.370	N/A	N/A	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.317	N/A	N/A	d.195.1	YopH tyrosine phosphatase N-terminal domain
View	Download	0.301	N/A	N/A	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.257	N/A	N/A	a.118.1	ARM repeat

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: