YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: gi|158257714, gi...
Organism: Homo sapiens
Length: 362 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|158257714, gi....

Description E-value Query
Range		 Subject
Range
gi|76617760|ref|... - PREDICTED: similar to Poly(rC)-binding protein 2 (Alpha-CP2) (Putative heterogeneous nuclear ribonuc...
gi|73996213 - gi|73996213|ref|XP_857432.1| PREDICTED: similar to Poly(rC)-binding protein 2 (Alpha-CP2) (Putative ...
 3.0E-76 [1..362] [1..362]
gi|62087230 - gi|62087230|dbj|BAD92062.1| poly(rC)-binding protein 2 isoform b variant [Homo sapiens]
 3.0E-76 [1..362] [13..373]
PCBP2 - poly(rC) binding protein 2
gi|61557337, gi|... - gi|61557337|ref|NP_001013241.1| poly(rC) binding protein 2 [Rattus norvegicus], gi|50926841|gb|AAH78...
 9.0E-74 [1..362] [1..365]
gi|1360003, gi|6... - gi|6997239|ref|NP_035172.1| poly(rC) binding protein 2 [Mus musculus], gi|1360003|emb|CAA66619.1| nu...
 2.0E-71 [1..362] [1..349]
gi|109065037 - gi|109065037|ref|XP_001099433.1| PREDICTED: similar to poly(rC) binding protein 3 isoform 3 [Macaca ...
gi|114684791 - gi|114684791|ref|XP_001157797.1| PREDICTED: hypothetical protein isoform 6 [Pan troglodytes]
 3.0E-70 [1..360] [33..391]

Back

Predicted Domain #1
Region A:
Residues: [1-84] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTGVIEGGL NVTLTIRLLM HGKEVGSIIG KKGESVKKMR EESGARINIS EGNCPERIIT  60
   61 LAGPTNAIFK AFAMIIDKLE EDIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 2axyA
Description: Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.76415077523249 bayes_pls_golite062009
mRNA binding 5.07455187994216 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
2.87067043110488 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
poly-pyrimidine tract binding 2.05765562493656 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
single-stranded RNA binding 0.981003625136521 bayes_pls_golite062009
mRNA 3'-UTR binding 0.722090816226222 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [85-181] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSMTNSTAAS RPPVTLRLVV PASQCGSLIG KGGCKIKEIR ESTGAQVQVA GDMLPNSTER  60
   61 AITIAGIPQS IIECVKQICV VMLESPPKGV TIPYRPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1sroA
Description: S1 RNA BINDING DOMAIN, NMR, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.29626483284963 bayes_pls_golite062009
RNA binding 3.99161318590718 bayes_pls_golite062009
structural constituent of ribosome 3.61794338675663 bayes_pls_golite062009
DNA binding 3.53568546959418 bayes_pls_golite062009
structural molecule activity 3.02980744557801 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
2.80746531284205 bayes_pls_golite062009
transcription regulator activity 1.84350127337404 bayes_pls_golite062009
structure-specific DNA binding 1.81524862921454 bayes_pls_golite062009
mRNA binding 1.660993824641 bayes_pls_golite062009
single-stranded DNA binding 1.62996999055328 bayes_pls_golite062009
transcription factor activity 1.21526211005888 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.15212468568198 bayes_pls_golite062009
exoribonuclease activity 1.10445667068538 bayes_pls_golite062009
sequence-specific DNA binding 0.85691075793641 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.83268201349295 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.635129001787169 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.477127926059749 bayes_pls_golite062009
RNA polymerase activity 0.477127926059749 bayes_pls_golite062009
transferase activity 0.249054945579328 bayes_pls_golite062009
translation regulator activity 0.22908707234671 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.179682348023561 bayes_pls_golite062009
protein binding 0.152645195799531 bayes_pls_golite062009
translation initiation factor activity 0.11625379846973 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [182-281] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSSPVIFAG GQDRYSTGSD SASFPHTTPS MCLNPDLEGP PLEAYTIQGQ YAIPQPDLTK  60
   61 LHQLAMQQSH FPMTHGNTGF SGIESSSPEV KGYWAGLDAS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
RNA binding 6.76415077523249 bayes_pls_golite062009
mRNA binding 5.07455187994216 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
2.87067043110488 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
poly-pyrimidine tract binding 2.05765562493656 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
single-stranded RNA binding 0.981003625136521 bayes_pls_golite062009
mRNA 3'-UTR binding 0.722090816226222 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [282-362] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQTTSHELTI PNDLIGCIIG RQGAKINEIR QMSGAQIKIA NPVEGSTDRQ VTITGSAASI  60
   61 SLAQYLINVR LSSETGGMGS S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1wvnA
Description: Crsytal Structure of domain 3 of human alpha polyC binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.76415077523249 bayes_pls_golite062009
mRNA binding 5.07455187994216 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
2.87067043110488 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
poly-pyrimidine tract binding 2.05765562493656 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
single-stranded RNA binding 0.981003625136521 bayes_pls_golite062009
mRNA 3'-UTR binding 0.722090816226222 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle