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View Structure Prediction Details

Protein: gi|158257714, gi...
Organism: Homo sapiens
Length: 362 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|158257714, gi....

Description E-value Query
Range		 Subject
Range
gi|76617760|ref|... - PREDICTED: similar to Poly(rC)-binding protein 2 (Alpha-CP2) (Putative heterogeneous nuclear ribonuc...
gi|73996213 - gi|73996213|ref|XP_857432.1| PREDICTED: similar to Poly(rC)-binding protein 2 (Alpha-CP2) (Putative ...
 3.0E-76 [1..362] [1..362]
gi|62087230 - gi|62087230|dbj|BAD92062.1| poly(rC)-binding protein 2 isoform b variant [Homo sapiens]
 3.0E-76 [1..362] [13..373]
PCBP2 - poly(rC) binding protein 2
gi|61557337, gi|... - gi|61557337|ref|NP_001013241.1| poly(rC) binding protein 2 [Rattus norvegicus], gi|50926841|gb|AAH78...
 9.0E-74 [1..362] [1..365]
gi|1360003, gi|6... - gi|6997239|ref|NP_035172.1| poly(rC) binding protein 2 [Mus musculus], gi|1360003|emb|CAA66619.1| nu...
 2.0E-71 [1..362] [1..349]
gi|109065037 - gi|109065037|ref|XP_001099433.1| PREDICTED: similar to poly(rC) binding protein 3 isoform 3 [Macaca ...
gi|114684791 - gi|114684791|ref|XP_001157797.1| PREDICTED: hypothetical protein isoform 6 [Pan troglodytes]
 3.0E-70 [1..360] [33..391]

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Predicted Domain #1
Region A:
Residues: [1-84] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTGVIEGGL NVTLTIRLLM HGKEVGSIIG KKGESVKKMR EESGARINIS EGNCPERIIT  60
   61 LAGPTNAIFK AFAMIIDKLE EDIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 2axyA
Description: Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.76415077523249 bayes_pls_golite062009
mRNA binding 5.07455187994216 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
2.87067043110488 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
poly-pyrimidine tract binding 2.05765562493656 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
single-stranded RNA binding 0.981003625136521 bayes_pls_golite062009
mRNA 3'-UTR binding 0.722090816226222 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [85-181] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSMTNSTAAS RPPVTLRLVV PASQCGSLIG KGGCKIKEIR ESTGAQVQVA GDMLPNSTER  60
   61 AITIAGIPQS IIECVKQICV VMLESPPKGV TIPYRPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1sroA
Description: S1 RNA BINDING DOMAIN, NMR, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.29626483284963 bayes_pls_golite062009
RNA binding 3.99161318590718 bayes_pls_golite062009
structural constituent of ribosome 3.61794338675663 bayes_pls_golite062009
DNA binding 3.53568546959418 bayes_pls_golite062009
structural molecule activity 3.02980744557801 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
2.80746531284205 bayes_pls_golite062009
transcription regulator activity 1.84350127337404 bayes_pls_golite062009
structure-specific DNA binding 1.81524862921454 bayes_pls_golite062009
mRNA binding 1.660993824641 bayes_pls_golite062009
single-stranded DNA binding 1.62996999055328 bayes_pls_golite062009
transcription factor activity 1.21526211005888 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.15212468568198 bayes_pls_golite062009
exoribonuclease activity 1.10445667068538 bayes_pls_golite062009
sequence-specific DNA binding 0.85691075793641 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.83268201349295 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.635129001787169 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.477127926059749 bayes_pls_golite062009
RNA polymerase activity 0.477127926059749 bayes_pls_golite062009
transferase activity 0.249054945579328 bayes_pls_golite062009
translation regulator activity 0.22908707234671 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.179682348023561 bayes_pls_golite062009
protein binding 0.152645195799531 bayes_pls_golite062009
translation initiation factor activity 0.11625379846973 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [182-281] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSSPVIFAG GQDRYSTGSD SASFPHTTPS MCLNPDLEGP PLEAYTIQGQ YAIPQPDLTK  60
   61 LHQLAMQQSH FPMTHGNTGF SGIESSSPEV KGYWAGLDAS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.604 a.156.1 S13-like H2TH domain
View Download 0.279 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.353 d.15.2 CAD & PB1 domains
View Download 0.298 d.58.17 Metal-binding domain
View Download 0.256 a.156.1 S13-like H2TH domain

Predicted functions:

Term Confidence Notes
RNA binding 6.76415077523249 bayes_pls_golite062009
mRNA binding 5.07455187994216 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
2.87067043110488 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
poly-pyrimidine tract binding 2.05765562493656 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
single-stranded RNA binding 0.981003625136521 bayes_pls_golite062009
mRNA 3'-UTR binding 0.722090816226222 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [282-362] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQTTSHELTI PNDLIGCIIG RQGAKINEIR QMSGAQIKIA NPVEGSTDRQ VTITGSAASI  60
   61 SLAQYLINVR LSSETGGMGS S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1wvnA
Description: Crsytal Structure of domain 3 of human alpha polyC binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.76415077523249 bayes_pls_golite062009
mRNA binding 5.07455187994216 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
2.87067043110488 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
poly-pyrimidine tract binding 2.05765562493656 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
single-stranded RNA binding 0.981003625136521 bayes_pls_golite062009
mRNA 3'-UTR binding 0.722090816226222 bayes_pls_golite062009
transcription repressor activity 0.392035003865213 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle