YRC Public Data Repository - Protein Structure Prediction

Protein:	MARS
Organism:	Homo sapiens
Length:	900 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MARS.

Description	E-value	Query Range	Subject Range
gi\|62897093 - gi\|62897093\|dbj\|BAD96487.1\| methionine-tRNA synthetase variant [Homo sapiens]	0.0	[1..900]	[1..900]
gi\|114644161 - gi\|114644161\|ref\|XP_509164.2\| PREDICTED: methionine-tRNA synthetase [Pan troglodytes]	0.0	[1..900]	[1..900]
gi\|109097438 - gi\|109097438\|ref\|XP_001116063.1\| PREDICTED: similar to methionine-tRNA synthetase isoform 4 [Macaca ...	0.0	[1..900]	[1..900]
SYMC_MOUSE - Methionine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Mars PE=1 SV=1	0.0	[1..900]	[1..902]
SYMC_BOVIN - Methionine--tRNA ligase, cytoplasmic OS=Bos taurus GN=MARS PE=2 SV=1	0.0	[1..900]	[1..898]
gi\|73968523 - gi\|73968523\|ref\|XP_849532.1\| PREDICTED: similar to methionine-tRNA synthetase isoform 3 [Canis famil...	0.0	[1..900]	[1..905]

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Predicted Domain #1

Region A:
Residues: [1-161]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFVSDGVP GCLPVLAAAG RARGRAEVLI STVGPEDCVV PFLTRPKVPV LQLDSGNYLF  60
   61 STSAICRYFF LLSGWEQDDL TNQWLEWEAT ELQPALSAAL YYLVVQGKKG EDVLGSVRRA 120
  121 LTHIDHSLSR QNCPFLAGET ESLADIVLWG ALYPLLQDPA Y

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.39794
Match:	1aw9A
Description:	STRUCTURE OF GLUTATHIONE S-TRANSFERASE III IN APO FORM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
copper ion binding	2.40748863139548	bayes_pls_golite062009
transcription regulator activity	2.30799114442278	bayes_pls_golite062009
binding	1.78119413208485	bayes_pls_golite062009
oxidoreductase activity	1.71351657881838	bayes_pls_golite062009
DNA binding	1.67625823552709	bayes_pls_golite062009
nucleic acid binding	1.64654156180867	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
transition metal ion binding	0.301062636244523	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [162-823]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPEELSALHS WFQTLSTQEP CQRAAETVLK QQGVLALRPY LQKQPQPSPA EGRAVTNEPE  60
   61 EEELATLSEE EIAMAVTAWE KGLESLPPLR PQQNPVLPVA GERNVLITSA LPYVNNVPHL 120
  121 GNIIGCVLSA DVFARYSRLR QWNTLYLCGT DEYGTATETK ALEEGLTPQE ICDKYHIIHA 180
  181 DIYRWFNISF DIFGRTTTPQ QTKITQDIFQ QLLKRGFVLQ DTVEQLRCEH CARFLADRFV 240
  241 EGVCPFCGYE EARGDQCDKC GKLINAVELK KPQCKVCRSC PVVQSSQHLF LDLPKLEKRL 300
  301 EEWLGRTLPG SDWTPNAQFI TRSWLRDGLK PRCITRDLKW GTPVPLEGFE DKVFYVWFDA 360
  361 TIGYLSITAN YTDQWERWWK NPEQVDLYQF MAKDNVPFHS LVFPCSALGA EDNYTLVSHL 420
  421 IATEYLNYED GKFSKSRGVG VFGDMAQDTG IPADIWRFYL LYIRPEGQDS AFSWTDLLLK 480
  481 NNSELLNNLG NFINRAGMFV SKFFGGYVPE MVLTPDDQRL LAHVTLELQH YHQLLEKVRI 540
  541 RDALRSILTI SRHGNQYIQV NEPWKRIKGS EADRQRAGTV TGLAVNIAAL LSVMLQPYMP 600
  601 TVSATIQAQL QLPPPACSIL LTNFLCTLPA GHQIGTVSPL FQKLENDQIE SLRQRFGGGQ 660
  661 AK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.522879
Match:	1ileA
Description:	ISOLEUCYL-TRNA SYNTHETASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	7.16276509815667	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.16276509815667	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.13957775963187	bayes_pls_golite062009
ligase activity	6.11211476973434	bayes_pls_golite062009
methionine-tRNA ligase activity	5.54691369460949	bayes_pls_golite062009
valine-tRNA ligase activity	2.76211928339998	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.63681738794687	bayes_pls_golite062009
leucine-tRNA ligase activity	2.62601062778624	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
isoleucine-tRNA ligase activity	2.06526306263547	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.88984817882585	bayes_pls_golite062009
binding	1.63608200808719	bayes_pls_golite062009
nucleic acid binding	1.63574252106186	bayes_pls_golite062009
arginine-tRNA ligase activity	1.50161401062914	bayes_pls_golite062009
nucleotidyltransferase activity	1.23060777952134	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.14187887833901	bayes_pls_golite062009
cysteine-tRNA ligase activity	0.844943947059557	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.30220012698115	bayes_pls_golite062009
transition metal ion binding	0.256582403702199	bayes_pls_golite062009
glutamine-tRNA ligase activity	0.118292082006187	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [824-900]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSPKPAVVET VTTAKPQQIQ ALMDEVTKQG NIVRELKAQK ADKNEVAAEV AKLLDLKKQL  60
   61 AVAEGKPPEA PKGKKKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	97.30103
Match:	1rqgA
Description:	Methionyl-tRNA synthetase from Pyrococcus abyssi
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: