YRC Public Data Repository - Protein Structure Prediction

Protein:	YPL088W
Organism:	Saccharomyces cerevisiae
Length:	342 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPL088W.

Description	E-value	Query Range	Subject Range
gi\|32141123, gi\|... - gi\|32141123\|ref\|NP_733514.1\| aldo/keto reductase [Streptomyces coelicolor A3(2)], gi\|24413737\|emb\|CA...	0.0	[4..339]	[1..318]
gi\|33596263 - gi\|33596263\|ref\|NP_883906.1\| putative oxidoreductase [Bordetella parapertussis 12822] gi\|33573266 - gi\|33573266\|emb\|CAE36928.1\| putative oxidoreductase [Bordetella parapertussis]	0.0	[4..339]	[1..321]
gi\|33602077, gi\|... - gi\|33602077\|ref\|NP_889637.1\| putative oxidoreductase [Bordetella bronchiseptica RB50], gi\|33576515\|e...	0.0	[4..339]	[1..321]
gi\|237797143, gi... - gi\|237797143\|ref\|YP_002887433.1\| putative oxidoreductase [Pseudomonas fluorescens], gi\|229424280\|gb\|... gi\|38638513, gi\|... - gi\|38638513\|ref\|NP_943099.1\| oxido-reductase/dehydratase [Pseudomonas sp. ND6], gi\|34335301\|gb\|AAP44... gi\|114050463 - gi\|114050463\|dbj\|BAF30949.1\| putative oxidoreductase [uncultured bacterium] gi\|28976073, gi\|... - gi\|32469911\|ref\|NP_863085.1\| putative oxidoreductase [Pseudomonas putida], gi\|28976073\|gb\|AAO64287.1...	0.0	[4..339]	[1..322]
gi\|33592063, gi\|... - gi\|33592063\|ref\|NP_879707.1\| putative oxidoreductase [Bordetella pertussis Tohama I], gi\|33571707\|em...	0.0	[4..339]	[1..321]
gi\|186466032, gi... - gi\|23128431\|ref\|ZP_00110278.1\| COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydroge...	0.0	[4..337]	[1..316]
gi\|24985014, gi\|... - gi\|26990085\|ref\|NP_745510.1\| aldo/keto reductase family oxidoreductase [Pseudomonas putida KT2440], ...	0.0	[4..338]	[1..325]
gi\|29828139, gi\|... - gi\|29828139\|ref\|NP_822773.1\| oxidoreductase [Streptomyces avermitilis MA-4680], gi\|29605241\|dbj\|BAC6...	0.0	[4..337]	[1..316]

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Predicted Domain #1

Region A:
Residues: [1-239]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLVKQVRLG NSGLKISPIV IGCMSYGSKK WADWVIEDKT QIFKIMKHCY DKGLRTFDTA  60
   61 DFYSNGLSER IIKEFLEYYS IKRETVVIMT KIYFPVDETL DLHHNFTLNE FEELDLSNQR 120
  121 GLSRKHIIAG VENSVKRLGT YIDLLQIHRL DHETPMKEIM KALNDVVEAG HVRYIGASSM 180
  181 LATEFAELQF TADKYGWFQF ISSQSYYNLL YREDERELIP FAKRHNIGLL PWSPNARGM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [285-324]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSMAMLSIAW VLHKGCHPIV GLNTTARVDE AIAALQVTLT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	327.383689
Match:	1exbA_
Description:	Voltage-dependent K+ channel beta subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
potassium channel activity	7.51963276589303	bayes_pls_golite062009
voltage-gated potassium channel activity	7.40239094355354	bayes_pls_golite062009
voltage-gated cation channel activity	6.67507110634301	bayes_pls_golite062009
metal ion transmembrane transporter activity	6.588881463055	bayes_pls_golite062009
voltage-gated ion channel activity	6.52286930358188	bayes_pls_golite062009
voltage-gated channel activity	6.50716590143831	bayes_pls_golite062009
cation channel activity	5.72172645555113	bayes_pls_golite062009
ion channel activity	5.15119282480682	bayes_pls_golite062009
passive transmembrane transporter activity	5.07214658557001	bayes_pls_golite062009
channel activity	5.07214658557001	bayes_pls_golite062009
substrate-specific channel activity	5.02503292701043	bayes_pls_golite062009
gated channel activity	4.92848832197692	bayes_pls_golite062009
oxidoreductase activity	3.33866876957213	bayes_pls_golite062009
pyridoxine 4-dehydrogenase activity	3.25535446462297	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.72342789448248	bayes_pls_golite062009
ion transmembrane transporter activity	2.63772951680109	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.62743427046359	bayes_pls_golite062009
cation transmembrane transporter activity	2.58068601897668	bayes_pls_golite062009
aldo-keto reductase activity	2.57303336304449	bayes_pls_golite062009
aryl-alcohol dehydrogenase activity	2.5168190536972	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.46488926936937	bayes_pls_golite062009
catalytic activity	1.68179794468736	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
aldehyde reductase activity	1.16639404121425	bayes_pls_golite062009
binding	1.15657176144267	bayes_pls_golite062009
transmembrane transporter activity	1.03420335553507	bayes_pls_golite062009
potassium channel regulator activity	1.03017249802223	bayes_pls_golite062009
substrate-specific transporter activity	0.783004917746429	bayes_pls_golite062009
protein binding	0.220529867719707	bayes_pls_golite062009
3-alpha-hydroxysteroid dehydrogenase (B-specific) activity	0.207008954325429	bayes_pls_golite062009
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	0.207008954325429	bayes_pls_golite062009
	0.139676323362391	bayes_pls_golite062009
channel regulator activity	0.12154513851913	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [240-284]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTRPLNQSTD RIKSDPTFKS LHLDNLEEEQ KEIINRVEKV SKDKK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [325-342]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEIKYLEEP YKPQRQRC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	327.383689
Match:	1exbA_
Description:	Voltage-dependent K+ channel beta subunit
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: