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Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity
Acc: GO:0047042
Aspect: Molecular Function
Desc: Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+.
Synonyms:
  • 3-alpha-HSD activity
  • 3alpha-hydroxysteroid oxidoreductase activity
  • sterognost 3alpha
  • hydroxyprostaglandin dehydrogenase activity
  • 3alpha-HSD
  • 3alpha-hydroxysteroid dehydrogenase (B-specific)
  • 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0047042 - 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity (interactive image map)
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Created and Maintained by: Michael Riffle