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View Structure Prediction Details

Protein: FRE5
Organism: Saccharomyces cerevisiae
Length: 694 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE5.

Description E-value Query
Range
Subject
Range
FRE5_YEAST - Ferric reductase transmembrane component 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
gi|190407674 - gi|190407674|gb|EDV10941.1| ferric reductase transmembrane component 5 precursor [Saccharomyces cere...
gi|207340797 - gi|207340797|gb|EDZ69036.1| YOR384Wp-like protein [Saccharomyces cerevisiae AWRI1631]
FRE5 - Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authe...
0.0 [1..694] [1..694]
RBOHB_SOLTU - Respiratory burst oxidase homolog protein B OS=Solanum tuberosum GN=RBOHB PE=1 SV=1
0.0 [72..692] [167..867]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [72..692] [222..921]
gi|28268680 - gi|28268680|dbj|BAC56865.1| respiratory burst oxidase homolog [Nicotiana benthamiana]
0.0 [72..692] [215..939]
RBOHD_ARATH - Respiratory burst oxidase homolog protein D OS=Arabidopsis thaliana GN=RBOHD PE=1 SV=1
0.0 [72..692] [222..921]
gi|125971776, gi... - gi|20805911|gb|AAM28891.1| NADPH oxidase [Nicotiana tabacum], gi|125971776|gb|ABN58915.1| rbohD [Nic...
0.0 [72..692] [214..938]

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Predicted Domain #1
Region A:
Residues: [1-185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFARLVLLL VYLAPGSLAK PASTKKRTQW DQIAIDACAK ELESHKFDTD VKGRHATLCT  60
   61 YEPALGSWLH CAKDVLDSRK KSKKIFEKTF SKINQYCHDY HKDEVVSNEE YYRIFANASL 120
  121 FIRPLDEVKE NIRYPVTPNK ASLDRWVWAY FGPLDNIDKG NVYGVTICLY WIGVLFIAAV 180
  181 YHFLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.045757
Match: 5tnc__
Description: Troponin C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cation binding 2.62077305565026 bayes_pls_golite062009
metal ion binding 2.62077305565026 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.61874575467092 bayes_pls_golite062009
ion binding 2.61312132078717 bayes_pls_golite062009
ion transmembrane transporter activity 2.57032504567157 bayes_pls_golite062009
cation transmembrane transporter activity 2.55650624542181 bayes_pls_golite062009
binding 2.54774920478325 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37465721152046 bayes_pls_golite062009
cation channel activity 1.49312394054212 bayes_pls_golite062009
calcium ion binding 1.40919295397643 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
protein binding 1.06263369232144 bayes_pls_golite062009
channel activity 1.05847414989139 bayes_pls_golite062009
passive transmembrane transporter activity 1.05847414989139 bayes_pls_golite062009
ion channel activity 1.0369591011376 bayes_pls_golite062009
substrate-specific channel activity 1.03529144716694 bayes_pls_golite062009
voltage-gated cation channel activity 0.986621437232479 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
voltage-gated ion channel activity 0.910148857310729 bayes_pls_golite062009
potassium channel activity 0.906643355854798 bayes_pls_golite062009
voltage-gated channel activity 0.896351900356978 bayes_pls_golite062009
gated channel activity 0.855502499003241 bayes_pls_golite062009
voltage-gated potassium channel activity 0.810245330492755 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
transcription regulator activity 0.529057692398468 bayes_pls_golite062009
molecular transducer activity 0.503769734882556 bayes_pls_golite062009
signal transducer activity 0.503769734882556 bayes_pls_golite062009
hydrolase activity 0.378268353045111 bayes_pls_golite062009
nucleic acid binding 0.345084390599452 bayes_pls_golite062009
0.34446792626966 bayes_pls_golite062009
channel regulator activity 0.32809521759917 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
DNA binding 0.14285249145193 bayes_pls_golite062009
cytoskeletal protein binding 0.0776924650284998 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [186-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSRLKQTVFK NKVSAFLRGH YVLPALVHNH AMSVGRWFFI GLVPTRLETL VLFGYVLLHG  60
   61 FLLSSYNFDH NELLSDRRSQ VLIFLSDRAG ILAFAHFPLI VLFGGKNSTM TWLTGIRYTA 120
  121 FITYHKWLGR FMLVDCTIHA IGYTYHAYIE NYWKYVKYSD 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [346-524]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LWTSGRHAMI IVGILVFFSF FFFRRHYYEL FVITHIILAI GFFHACWKHC YKLGWGEWIM  60
   61 ACALFWIADR ILRLIKIAIF GMPWAKLKLC GESMIEVRIS KSSKWWKAEP GQYIYLYFLR 120
  121 PKIFWQSHPF TVMDSLVEDG ELVVVITVKN GLTKKLQEYL LESEGYTEMR VLAEGPYGQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.045757
Match: 1cqxA_
Description: Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [525-694]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STRTHLFESL LFIAGGAGVP GPLSMAIKAG RQVKSNDSHQ MIKFVWSVRN LDLLEVYRKE  60
   61 IMVLKELNID TKIYFTGERK DESNTEEGAI ANMSTEGRLL TTSKSAEMIT DFGRPNIDEI 120
  121 IEEAVSGAKS LLVTCCGSEG FVDKTRELTA KRVLEHGDKW IEYVEEFQNW 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.045757
Match: 1cqxA_
Description: Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.45374095556065 bayes_pls_golite062009
transferase activity 1.15480450573972 bayes_pls_golite062009
binding 1.13408475648113 bayes_pls_golite062009
oxidoreductase activity 0.27336340260908 bayes_pls_golite062009
protein binding 0.144900113694048 bayes_pls_golite062009
cofactor binding 0.0731141170494622 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle