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View Structure Prediction Details

Protein: LDB19
Organism: Saccharomyces cerevisiae
Length: 818 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LDB19.

Description E-value Query
Range		 Subject
Range
gi|151945402 - gi|151945402|gb|EDN63645.1| conserved protein [Saccharomyces cerevisiae YJM789]
LDB19_YEAST - Protein LDB19 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LDB19 PE=1 SV=1
gi|190407620 - gi|190407620|gb|EDV10887.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
LDB19 - Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquit...
 0.0 [1..818] [1..818]
YNSK_SCHPO - Uncharacterized protein C18H10.20c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC18H...
SPBC18H10.20c - conserved fungal protein
 2.0E-86 [109..352] [20..250]
gi|85090631 - gi|85090631|ref|XP_958509.1| hypothetical protein NCU09514 [Neurospora crassa OR74A]
gi|32418790, gi|... - gi|32418790|ref|XP_329873.1| hypothetical protein [Neurospora crassa], gi|28919878|gb|EAA29273.1| co...
 8.0E-78 [115..346] [145..366]

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Predicted Domain #1
Region A:
Residues: [1-79] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFSRLTSTH QSNHNGYSNS NKKGQSLPLT LSIDVESPPC VLYGSAMESS GAVLSGLFTV  60
   61 TVVDPYSSAE DKSLKNTES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
clathrin binding 2.57748868504781 bayes_pls_golite062009
binding 2.01341910518392 bayes_pls_golite062009
protein binding 1.608080422834 bayes_pls_golite062009
transporter activity 1.10239137184953 bayes_pls_golite062009
transmembrane transporter activity 0.949536954960448 bayes_pls_golite062009
substrate-specific transporter activity 0.781060752903079 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.660409340901077 bayes_pls_golite062009
ion transmembrane transporter activity 0.56446678342098 bayes_pls_golite062009
cation transmembrane transporter activity 0.486294295028555 bayes_pls_golite062009
channel activity 0.465630241372545 bayes_pls_golite062009
passive transmembrane transporter activity 0.465630241372545 bayes_pls_golite062009
substrate-specific channel activity 0.455589501590218 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.44519612509266 bayes_pls_golite062009
potassium channel activity 0.423464159542763 bayes_pls_golite062009
cation channel activity 0.406614358442595 bayes_pls_golite062009
voltage-gated cation channel activity 0.402494949667906 bayes_pls_golite062009
voltage-gated ion channel activity 0.39571309893169 bayes_pls_golite062009
ion channel activity 0.395022246697853 bayes_pls_golite062009
voltage-gated channel activity 0.387394052239826 bayes_pls_golite062009
voltage-gated potassium channel activity 0.326855275194847 bayes_pls_golite062009
gated channel activity 0.266124158878986 bayes_pls_golite062009
cytoskeletal protein binding 0.0852462445742306 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [80-387] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVSTTSKSLK RKSTFGSALS SRLSSLSAST SNISPSTSST SISHSPTPAN LRIMAGYTKI  60
   61 TITSVTLSLV QKIHFHKPFV PNISSMQTCM NCKTKITNMK SWEIQSNTQD LSVGSHSYPF 120
  121 SYLIPGSVPC SSSLGATAET QVKYELIAVV TYIDPHRNSF SSGHSTPRKE GSSSKKRLLQ 180
  181 LAMPIAVTRS IPRGPDKNSL RVFPPTELTA AAVLPNVVYP KSTFPLEMKL DGVSSGDRRW 240
  241 RMRKLSWRIE ETTRVKAHAC PVHKHELRQL EEQVKIKESE KSKKPRSHIK RYGELGPQIR 300
  301 VAVNSLEN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [388-818] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSQRLPGEP GREQAPNSSG PASTGNVGLD DENPVNEDEE DQPGSEFIHP SDDALRQELL  60
   61 MQQQRARQQQ LQQELKNNSS LFTEEVRIIS KGEMKSGWKT DFDNNGKIEL VTEIDCMGLN 120
  121 SGVSNPVMHA STLQTPSTGN KKPSINVACD IQDPNLGLYV SHILAVEIVV AEETLQYANG 180
  181 QPIRKPNSKN KKETNNNTMN VHNPDQRLAE LSPIFANRNT PKVRRMGPED ITPVNSNKSN 240
  241 HSTNKEKASN GASNSNIVSV PTGAARVLRM QFRLTVTERS GLGISWDEEV PPIYQDVELL 300
  301 SPPCYELSIN NGIKNKLYST MSTPVRSEDD FVGGSDEDIG NYESQGLEPG PNVQEVTITQ 360
  361 NKLTIPPTAH HYQPASSSQR SLTTVQSPPL ESVVSVQGSV PFRGHVLTPH STRDIRIQNF 420
  421 SDFLDSNRIT Q

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle