YRC Public Data Repository - Protein Structure Prediction

Protein:	ESA1
Organism:	Saccharomyces cerevisiae
Length:	445 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ESA1.

Description	E-value	Query Range	Subject Range
ESA1_YEAST - Histone acetyltransferase ESA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ESA1 PE=1... gi\|190407549 - gi\|190407549\|gb\|EDV10816.1\| NuA4 complex component [Saccharomyces cerevisiae RM11-1a] gi\|151945330 - gi\|151945330\|gb\|EDN63573.1\| NuA4 histone acetyltransferase subunit [Saccharomyces cerevisiae YJM789] ESA1 - Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved int...	0.0	[1..445]	[1..445]
mst1 - histone acetyltransferase Mst1 ESA1_SCHPO - Histone acetyltransferase mst1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mst1 PE=1 S...	0.0	[1..445]	[1..463]
gi\|4097714 - gi\|4097714\|gb\|AAD00163.1\| cPLA2 interacting protein [Homo sapiens]	0.0	[17..434]	[3..453]
KAT8_MOUSE - Histone acetyltransferase KAT8 OS=Mus musculus GN=Kat8 PE=1 SV=1	0.0	[18..435]	[52..449]
MYST1_ARATH - Histone acetyltransferase of the MYST family 1 OS=Arabidopsis thaliana GN=HAM1 PE=1 SV=1	0.0	[8..433]	[46..440]
KAT6B_MACFA - Histone acetyltransferase KAT6B OS=Macaca fascicularis GN=KAT6B PE=2 SV=1	0.0	[68..440]	[321..704]

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Predicted Domain #1

Region A:
Residues: [1-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHDGKEEPG IAKKINSVDD IIIKCQCWVQ KNDEERLAEI LSINTRKAPP KFYVHYVNYN  60
   61 KRLDEWITTD RINLDKEVLY PKLKATDEDN KKQKKKKATN TSETPQDSLQ DGVDGFSREN 120
  121 TDVMDLDNLN VQGIKDENIS H

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.5
Match:	1ap0_
Description:	Heterochromatin protein 1, HP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription repressor activity	4.08500855631983	bayes_pls_golite062009
chromatin binding	3.84065302930105	bayes_pls_golite062009
transcription regulator activity	3.64390820819794	bayes_pls_golite062009
methylated histone residue binding	3.42338304360938	bayes_pls_golite062009
binding	3.06758476214113	bayes_pls_golite062009
protein binding	2.66728689880621	bayes_pls_golite062009
transcription elongation regulator activity	2.46353586381231	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
histone binding	2.00388175060339	bayes_pls_golite062009
transcription activator activity	1.46529895769882	bayes_pls_golite062009
sequence-specific DNA binding	1.10020047862576	bayes_pls_golite062009
DNA-dependent ATPase activity	0.998957812785999	bayes_pls_golite062009
general transcriptional repressor activity	0.75184432495983	bayes_pls_golite062009
DNA helicase activity	0.726970683178132	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.494788451379878	bayes_pls_golite062009
transcription corepressor activity	0.294457188332415	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [142-218]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDEIKKLRTS GSMTQNPHEV ARVRNLNRII MGKYEIEPWY FSPYPIELTD EDFIYIDDFT  60
   61 LQYFGSKKQY ERYRKKC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1714.0
Match:	1fy7A_
Description:	Histone acetyltransferase ESA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
N-acetyltransferase activity	10.330867741687	bayes_pls_golite062009
histone acetyltransferase activity	10.2385402730839	bayes_pls_golite062009
lysine N-acetyltransferase activity	10.2385402730839	bayes_pls_golite062009
N-acyltransferase activity	10.2097972775096	bayes_pls_golite062009
acetyltransferase activity	9.5414870492393	bayes_pls_golite062009
acyltransferase activity	8.84144467104026	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	8.80032457938662	bayes_pls_golite062009
transferase activity, transferring acyl groups	8.58458341779614	bayes_pls_golite062009
	7.30820970670781	bayes_pls_golite062009
	5.22897636875434	bayes_pls_golite062009
H3 histone acetyltransferase activity	3.57980162499154	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.87587084880956	bayes_pls_golite062009
transferase activity	2.87429355361226	bayes_pls_golite062009
transcription regulator activity	2.24760844790231	bayes_pls_golite062009
transcription activator activity	2.22111981353244	bayes_pls_golite062009
nucleic acid binding	2.13750665291344	bayes_pls_golite062009
catalytic activity	1.97933499002461	bayes_pls_golite062009
transcription repressor activity	1.31507488567214	bayes_pls_golite062009
binding	1.22537494136129	bayes_pls_golite062009
transcription coactivator activity	1.2180007740195	bayes_pls_golite062009
transcription factor binding	1.13174003342838	bayes_pls_golite062009
protein binding	1.12627968510377	bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity	0.774009286200155	bayes_pls_golite062009
myristoyltransferase activity	0.774009286200155	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.605899196605446	bayes_pls_golite062009
histone binding	0.582104626133107	bayes_pls_golite062009
transcription cofactor activity	0.31196049232138	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [219-314]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLRHPPGNEI YRDDYVSFFE IDGRKQRTWC RNLCLLSKLF LDHKTLYYDV DPFLFYCMTR  60
   61 RDELGHHLVG YFSKEKESAD GYNVACILTL PQYQRM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1714.0
Match:	1fy7A_
Description:	Histone acetyltransferase ESA1
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [315-350]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYGKLLIEFS YELSKKENKV GSPEKPLSDL GLLSYR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [421-445]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRTIDPNRLI WKPPVFTASQ LRFAW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1714.0
Match:	1fy7A_
Description:	Histone acetyltransferase ESA1
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [351-420]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AYWSDTLITL LVEHQKEITI DEISSMTSMT TTDILHTAKT LNILRYYKGQ HIIFLNEDIL  60
   61 DRYNRLKAKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1714.0
Match:	1fy7A_
Description:	Histone acetyltransferase ESA1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: