YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: MKK1
Organism: Saccharomyces cerevisiae
Length: 508 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MKK1.

Description E-value Query
Range		 Subject
Range
MKK1 - Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell in...
MKK1_YEAST - MAP kinase kinase MKK1/SSP32 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MKK1 PE=1 S...
gi|151945319 - gi|151945319|gb|EDN63562.1| MAP kinase kinase (MEK) [Saccharomyces cerevisiae YJM789]
gi|190407539 - gi|190407539|gb|EDV10806.1| MAP kinase kinase [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..508] [1..508]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [31..501] [100..533]
gi|189491751, gi... - gi|57284082|emb|CAI43167.1| p21 protein (Cdc42/Rac)-activated kinase 3 [Homo sapiens], gi|57284006|e...
gi|157170250 - gi|157170250|gb|AAI52762.1| P21 protein (Cdc42/Rac)-activated kinase 3 [synthetic construct]
ENSPTRT00000049237 - null
 0.0 [31..503] [95..534]
PAK1_RAT - Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3
 0.0 [31..501] [100..533]
gi|3420949 - gi|3420949|gb|AAC31969.1| Cdc42/Rac effector kinase; PAK-3 [Mus musculus]
 0.0 [31..503] [95..534]
gi|1168176 - gi|1168176|gb|AAB35358.1| mPAK-3=p21Cdc42/Rac activated kinase [mice, fibroblast, Peptide, 543 aa]
 0.0 [31..503] [95..534]

Back

Predicted Domain #1
Region A:
Residues: [1-83] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASLFRPPES AKCNPNSPRL KLPLLRNNQV DENNIYLTSN GSSTTAYSSH TPEPLTSSTS  60
   61 TLFSQTRLHP SDSSMTLNTM KKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.30103
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [84-152] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAPPSLPSLS INSQSKCKTL PELVPIADVS DGKHDLGLKQ RVIAENELSG NSDLTPSSMA  60
   61 SPFSHTNTS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [153-301] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPYLRNDLSN SVGSDFSNLI SAYEQSSSPI KSSSQPKSSS ESYIDLNSVR DVDQLDENGW  60
   61 KYANLKDRIE TLGILGEGAG GSVSKCKLKN GSKIFALKVI NTLNTDPEYQ KQIFRELQFN 120
  121 RSFQSEYIVR YYGMFTDDEN SSIYIAMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 373.9897
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
structural constituent of muscle 1.19908793854422 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
telethonin binding 1.04264263421201 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.553953601841147 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
transmembrane transporter activity 0.37676337669549 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
alpha-actinin binding 0.181804774839734 bayes_pls_golite062009
protein complex binding 0.132247221889251 bayes_pls_golite062009
substrate-specific transporter activity 0.0611721261859464 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [302-508] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGRSLDAIY KNLLERGGRI SEKVLGKIAE AVLRGLSYLH EKKVIHRDIK PQNILLNENG  60
   61 QVKLCDFGVS GEAVNSLATT FTGTSFYMAP ERIQGQPYSV TSDVWSLGLT ILEVANGKFP 120
  121 CSSEKMAANI APFELLMWIL TFTPELKDEP ESNIIWSPSF KSFIDYCLKK DSRERPSPRQ 180
  181 MINHPWIKGQ MKKNVNMEKF VRKCWKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 373.9897
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle