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View Structure Prediction Details

Protein: MKK1
Organism: Saccharomyces cerevisiae
Length: 508 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MKK1.

Description E-value Query
Range		 Subject
Range
MKK1 - Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell in...
MKK1_YEAST - MAP kinase kinase MKK1/SSP32 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MKK1 PE=1 S...
gi|151945319 - gi|151945319|gb|EDN63562.1| MAP kinase kinase (MEK) [Saccharomyces cerevisiae YJM789]
gi|190407539 - gi|190407539|gb|EDV10806.1| MAP kinase kinase [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..508] [1..508]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [31..501] [100..533]
gi|189491751, gi... - gi|57284082|emb|CAI43167.1| p21 protein (Cdc42/Rac)-activated kinase 3 [Homo sapiens], gi|57284006|e...
gi|157170250 - gi|157170250|gb|AAI52762.1| P21 protein (Cdc42/Rac)-activated kinase 3 [synthetic construct]
ENSPTRT00000049237 - null
 0.0 [31..503] [95..534]
PAK1_RAT - Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3
 0.0 [31..501] [100..533]
gi|3420949 - gi|3420949|gb|AAC31969.1| Cdc42/Rac effector kinase; PAK-3 [Mus musculus]
 0.0 [31..503] [95..534]
gi|1168176 - gi|1168176|gb|AAB35358.1| mPAK-3=p21Cdc42/Rac activated kinase [mice, fibroblast, Peptide, 543 aa]
 0.0 [31..503] [95..534]

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Predicted Domain #1
Region A:
Residues: [1-83] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASLFRPPES AKCNPNSPRL KLPLLRNNQV DENNIYLTSN GSSTTAYSSH TPEPLTSSTS  60
   61 TLFSQTRLHP SDSSMTLNTM KKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.30103
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [84-152] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAPPSLPSLS INSQSKCKTL PELVPIADVS DGKHDLGLKQ RVIAENELSG NSDLTPSSMA  60
   61 SPFSHTNTS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.511 a.4.1 Homeodomain-like
View Download 0.396 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.420 a.144.1 PABC (PABP) domain
View Download 0.396 a.36.1 Signal peptide-binding domain
View Download 0.358 a.180.1 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA
View Download 0.322 d.15.2 CAD & PB1 domains
View Download 0.317 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.265 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.254 a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.241 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.232 a.156.1 S13-like H2TH domain
View Download 0.231 a.4.1 Homeodomain-like
View Download 0.230 a.85.1 Hemocyanin, N-terminal domain
View Download 0.229 a.156.1 S13-like H2TH domain
View Download 0.225 a.20.1 PGBD-like
View Download 0.218 a.39.1 EF-hand
View Download 0.209 c.47.1 Thioredoxin-like

Predicted Domain #3
Region A:
Residues: [153-301] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPYLRNDLSN SVGSDFSNLI SAYEQSSSPI KSSSQPKSSS ESYIDLNSVR DVDQLDENGW  60
   61 KYANLKDRIE TLGILGEGAG GSVSKCKLKN GSKIFALKVI NTLNTDPEYQ KQIFRELQFN 120
  121 RSFQSEYIVR YYGMFTDDEN SSIYIAMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 373.9897
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
structural constituent of muscle 1.19908793854422 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
telethonin binding 1.04264263421201 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.553953601841147 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
transmembrane transporter activity 0.37676337669549 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
alpha-actinin binding 0.181804774839734 bayes_pls_golite062009
protein complex binding 0.132247221889251 bayes_pls_golite062009
substrate-specific transporter activity 0.0611721261859464 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [302-508] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGRSLDAIY KNLLERGGRI SEKVLGKIAE AVLRGLSYLH EKKVIHRDIK PQNILLNENG  60
   61 QVKLCDFGVS GEAVNSLATT FTGTSFYMAP ERIQGQPYSV TSDVWSLGLT ILEVANGKFP 120
  121 CSSEKMAANI APFELLMWIL TFTPELKDEP ESNIIWSPSF KSFIDYCLKK DSRERPSPRQ 180
  181 MINHPWIKGQ MKKNVNMEKF VRKCWKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 373.9897
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle