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View Structure Prediction Details

Protein: HIR2
Organism: Saccharomyces cerevisiae
Length: 875 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIR2.

Description E-value Query
Range
Subject
Range
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
0.0 [67..750] [865..1491]
HIR2_YEAST - Protein HIR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIR2 PE=1 SV=2
HIR2 - Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene tra...
0.0 [1..875] [1..875]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLLKYPLDI HNEQVNALAA LGPYIILAGS GGHVMAWRQQ QLVDTAFDRV MIKDLKPEVS  60
   61 FQVDQDTTGD IFFITGDLET LYIGS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.583 0.128 transcription corepressor activity d.58.7 RNA-binding domain, RBD
View Download 0.574 0.057 transcription corepressor activity d.15.7 Immunoglobulin-binding domains
View Download 0.675 0.028 transcription corepressor activity d.95.2 Homing endonucleases
View Download 0.615 0.003 transcription corepressor activity d.58.49 YajQ-like
View Download 0.563 N/A N/A a.28.1 ACP-like
View Download 0.538 N/A N/A d.58.11 EF-G/eEF-2 domains III and V
View Download 0.529 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.519 N/A N/A d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.501 N/A N/A d.58.11 EF-G/eEF-2 domains III and V
View Download 0.491 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.485 N/A N/A b.34.1 C-terminal domain of transcriptional repressors
View Download 0.482 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.479 N/A N/A d.95.2 Homing endonucleases
View Download 0.471 N/A N/A d.58.48 MTH1187-like
View Download 0.469 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.461 N/A N/A d.95.2 Homing endonucleases
View Download 0.449 N/A N/A d.15.2 CAD & PB1 domains
View Download 0.448 N/A N/A c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.442 N/A N/A d.95.1 Glucose permease domain IIB
View Download 0.441 N/A N/A d.58.48 MTH1187-like
View Download 0.441 N/A N/A d.141.1 Ribosomal protein L6
View Download 0.430 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.423 N/A N/A c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.420 N/A N/A d.206.1 YggU-like
View Download 0.417 N/A N/A d.58.5 GlnB-like
View Download 0.417 N/A N/A d.58.48 MTH1187-like
View Download 0.408 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.407 N/A N/A d.58.17 Metal-binding domain
View Download 0.405 N/A N/A b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.401 N/A N/A d.58.49 YajQ-like
View Download 0.401 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.398 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.396 N/A N/A d.15.2 CAD & PB1 domains
View Download 0.393 N/A N/A b.34.1 C-terminal domain of transcriptional repressors
View Download 0.389 N/A N/A d.58.49 YajQ-like
View Download 0.385 N/A N/A b.71.1 Glycosyl hydrolase domain
View Download 0.377 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.375 N/A N/A a.28.1 ACP-like
View Download 0.374 N/A N/A d.15.2 CAD & PB1 domains
View Download 0.373 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.372 N/A N/A d.58.49 YajQ-like
View Download 0.369 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.361 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.361 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.357 N/A N/A d.58.14 Ribosomal protein S6
View Download 0.353 N/A N/A d.58.5 GlnB-like
View Download 0.352 N/A N/A d.58.5 GlnB-like
View Download 0.351 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.346 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.346 N/A N/A d.95.2 Homing endonucleases
View Download 0.344 N/A N/A d.95.2 Homing endonucleases
View Download 0.341 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.338 N/A N/A b.1.2 Fibronectin type III
View Download 0.329 N/A N/A d.131.1 DNA clamp
View Download 0.328 N/A N/A d.95.2 Homing endonucleases
View Download 0.327 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.327 N/A N/A d.1.1 Microbial ribonucleases
View Download 0.326 N/A N/A d.57.1 DNA damage-inducible protein DinI
View Download 0.326 N/A N/A d.15.1 Ubiquitin-like
View Download 0.325 N/A N/A d.58.17 Metal-binding domain
View Download 0.314 N/A N/A d.74.2 C-terminal domain of arginine repressor
View Download 0.311 N/A N/A d.52.1 Alpha-lytic protease prodomain
View Download 0.310 N/A N/A d.32.1 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
View Download 0.306 N/A N/A d.58.24 CheY-binding domain of CheA
View Download 0.302 N/A N/A d.206.1 YggU-like
View Download 0.300 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.299 N/A N/A d.52.1 Alpha-lytic protease prodomain
View Download 0.296 N/A N/A d.95.2 Homing endonucleases
View Download 0.290 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.285 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.283 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.282 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.280 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.278 N/A N/A a.74.1 Cyclin-like
View Download 0.276 N/A N/A d.95.2 Homing endonucleases
View Download 0.276 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.275 N/A N/A d.21.1 Diaminopimelate epimerase-like
View Download 0.272 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.271 N/A N/A b.40.2 Bacterial enterotoxins
View Download 0.271 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.267 N/A N/A d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.266 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.263 N/A N/A d.32.1 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
View Download 0.263 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.261 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.259 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.259 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.257 N/A N/A d.1.1 Microbial ribonucleases
View Download 0.254 N/A N/A d.58.35 Pseudouridine synthase
View Download 0.253 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.248 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.248 N/A N/A d.26.3 Chitinase insertion domain
View Download 0.243 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.243 N/A N/A d.206.1 YggU-like
View Download 0.242 N/A N/A c.47.1 Thioredoxin-like
View Download 0.239 N/A N/A d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.238 N/A N/A d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.237 N/A N/A a.28.1 ACP-like
View Download 0.237 N/A N/A d.58.2 Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
View Download 0.237 N/A N/A d.74.5 Hypothetical protein Yml108w
View Download 0.234 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.228 N/A N/A d.13.1 HIT-like
View Download 0.226 N/A N/A d.58.24 CheY-binding domain of CheA
View Download 0.224 N/A N/A d.58.5 GlnB-like
View Download 0.221 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.220 N/A N/A d.32.1 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
View Download 0.219 N/A N/A b.71.1 Glycosyl hydrolase domain
View Download 0.218 N/A N/A d.58.42 N-utilization substance G protein NusG, N-terminal domain
View Download 0.216 N/A N/A d.68.7 R3H domain
View Download 0.215 N/A N/A d.9.2 Description not found.
View Download 0.214 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.211 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.207 N/A N/A c.3.1 FAD/NAD(P)-binding domain
View Download 0.201 N/A N/A d.26.3 Chitinase insertion domain

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 2.79445416141967 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
transcription repressor activity 2.29049708962212 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
transcription corepressor activity 1.41752877005447 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
cytoskeletal protein binding 1.19593750149343 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
0.88172763425403 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
actin binding 0.529861581509437 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
snoRNA binding 0.347797037104681 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
transporter activity 0.284701931503833 bayes_pls_golite062009
DNA-dependent ATPase activity 0.164101908612691 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009
structural molecule activity 0.0936365746095786 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [86-473]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHRLWGYSGW LCRDTNNINS VEKMNSKLLF ECKSPSTITD VKYDINLGIL FVLLSNENKI  60
   61 LLFRHKTFDK LSEITIDKAS KPITGIIDPT GQTFTVMTSD RSILVYQINK TGTHKLINKL 120
  121 TQHVQMYPLH YRISMSPQAD ILPVINSVKG VPNNATSCTA LLDRNNNYKV TKTLVTPSSN 180
  181 GCRVLVYSPA FYEKPNLKKG TSTRYNLIAT SGSTDGTILV WNTKRMKPLF NALQVSSTAI 240
  241 NDMSWSQDGF TLFAISNDAT LYTFAFQEKD LGVALPQTEI KSLQEVNKKL PKLEEPLAEQ 300
  301 IPKSFPENIK LEESASAAPI PNDIGRSAVG KKPTKKKTAN NQTNGIKTIQ STSMEFNTPS 360
  361 YTVPRDLKRK PKEATPSNIA PGSKKQKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.39794
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.23858959608048 bayes_pls_golite062009
DNA binding 4.78517210147551 bayes_pls_golite062009
nucleic acid binding 4.72059012764202 bayes_pls_golite062009
transcription factor activity 4.02736190679869 bayes_pls_golite062009
transcription repressor activity 3.60278632732466 bayes_pls_golite062009
binding 3.37660003833383 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.84400558797599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.41045867230388 bayes_pls_golite062009
sequence-specific DNA binding 2.21432668306508 bayes_pls_golite062009
transcription activator activity 2.13702350917359 bayes_pls_golite062009
transcription elongation regulator activity 1.75305601393584 bayes_pls_golite062009
structure-specific DNA binding 0.795220428630727 bayes_pls_golite062009
transcription factor binding 0.752335897765285 bayes_pls_golite062009
protein binding 0.726445167461826 bayes_pls_golite062009
specific transcriptional repressor activity 0.710995647413393 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.490809930581315 bayes_pls_golite062009
transcription corepressor activity 0.252392400929265 bayes_pls_golite062009
DNA-dependent ATPase activity 0.224230323813474 bayes_pls_golite062009
structural molecule activity 0.128347187436068 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.0406721670764369 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [474-698]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELQPIDFLDT GLLLPNTSFS RIRLATPKIR STFKYSPINN PNLILDVKNG SGNEQRPTIV  60
   61 KLTSKVLDQD QVLFQDFIPK LITICTAGDT FWSFCSEDGS IYIYSDSGRK LMAPLVLGVS 120
  121 ISFLEACGTY LLCLTSIGEL YCWNIEQKKL AFPTNTIYPL LNPSLRYSDD ILTRAENITL 180
  181 CSITKKGVPL VTLSNGDGYL FDKNMETWLL VSDGWWAYGS QYWDT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [699-752]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNTTGLSSSK ANTDSFNGSE SNINEIVSDI KNDNQSIINF LECKTNDELN RKGR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.300 a.5.2 UBA-like
View Download 0.524 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.319 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.439 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.295 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.291 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.281 a.5.2 UBA-like
View Download 0.268 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.268 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.260 a.4.11 RNA polymerase subunit RPB10
View Download 0.239 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.238 a.5.2 UBA-like
View Download 0.235 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.230 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.221 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.219 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.209 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.209 a.5.2 UBA-like
View Download 0.203 b.40.4 Nucleic acid-binding proteins

Predicted Domain #5
Region A:
Residues: [753-875]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKNLQRFART ILMKEGFENM EEIVTLSHLE NKILISIRLE EPEEFSKLMM VYCIRLSELG  60
   61 YMDRLNDVFQ WLYDDLPISG TGSAFADKDF KRNLLKKILI ACGDIRQVQR VTTRYAKEMN 120
  121 IIS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.63
Match: 1bgxT
Description: 5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle