| Protein: | HIR2 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 875 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIR2.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [67..750] | [865..1491] |
|
|
0.0 | [1..875] | [1..875] |
|
Region A: Residues: [1-85] |
1 11 21 31 41 51
| | | | | |
1 MRLLKYPLDI HNEQVNALAA LGPYIILAGS GGHVMAWRQQ QLVDTAFDRV MIKDLKPEVS 60
61 FQVDQDTTGD IFFITGDLET LYIGS
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.583 | 0.128 | transcription corepressor activity | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.574 | 0.057 | transcription corepressor activity | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.675 | 0.028 | transcription corepressor activity | d.95.2 | Homing endonucleases |
| View | Download | 0.615 | 0.003 | transcription corepressor activity | d.58.49 | YajQ-like |
| View | Download | 0.563 | N/A | N/A | a.28.1 | ACP-like |
| View | Download | 0.538 | N/A | N/A | d.58.11 | EF-G/eEF-2 domains III and V |
| View | Download | 0.529 | N/A | N/A | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.519 | N/A | N/A | d.58.23 | Probable ACP-binding domain of malonyl-CoA ACP transacylase |
| View | Download | 0.501 | N/A | N/A | d.58.11 | EF-G/eEF-2 domains III and V |
| View | Download | 0.491 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.485 | N/A | N/A | b.34.1 | C-terminal domain of transcriptional repressors |
| View | Download | 0.482 | N/A | N/A | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.479 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.471 | N/A | N/A | d.58.48 | MTH1187-like |
| View | Download | 0.469 | N/A | N/A | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.461 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.449 | N/A | N/A | d.15.2 | CAD & PB1 domains |
| View | Download | 0.448 | N/A | N/A | c.55.7 | Methylated DNA-protein cysteine methyltransferase domain |
| View | Download | 0.442 | N/A | N/A | d.95.1 | Glucose permease domain IIB |
| View | Download | 0.441 | N/A | N/A | d.58.48 | MTH1187-like |
| View | Download | 0.441 | N/A | N/A | d.141.1 | Ribosomal protein L6 |
| View | Download | 0.430 | N/A | N/A | d.58.10 | Acylphosphatase-like |
| View | Download | 0.423 | N/A | N/A | c.55.7 | Methylated DNA-protein cysteine methyltransferase domain |
| View | Download | 0.420 | N/A | N/A | d.206.1 | YggU-like |
| View | Download | 0.417 | N/A | N/A | d.58.5 | GlnB-like |
| View | Download | 0.417 | N/A | N/A | d.58.48 | MTH1187-like |
| View | Download | 0.408 | N/A | N/A | d.58.10 | Acylphosphatase-like |
| View | Download | 0.407 | N/A | N/A | d.58.17 | Metal-binding domain |
| View | Download | 0.405 | N/A | N/A | b.114.1 | N-utilization substance G protein NusG, insert domain |
| View | Download | 0.401 | N/A | N/A | d.58.49 | YajQ-like |
| View | Download | 0.401 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.398 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.396 | N/A | N/A | d.15.2 | CAD & PB1 domains |
| View | Download | 0.393 | N/A | N/A | b.34.1 | C-terminal domain of transcriptional repressors |
| View | Download | 0.389 | N/A | N/A | d.58.49 | YajQ-like |
| View | Download | 0.385 | N/A | N/A | b.71.1 | Glycosyl hydrolase domain |
| View | Download | 0.377 | N/A | N/A | d.58.10 | Acylphosphatase-like |
| View | Download | 0.375 | N/A | N/A | a.28.1 | ACP-like |
| View | Download | 0.374 | N/A | N/A | d.15.2 | CAD & PB1 domains |
| View | Download | 0.373 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.372 | N/A | N/A | d.58.49 | YajQ-like |
| View | Download | 0.369 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.361 | N/A | N/A | d.68.1 | Translation initiation factor IF3, C-terminal domain |
| View | Download | 0.361 | N/A | N/A | d.68.1 | Translation initiation factor IF3, C-terminal domain |
| View | Download | 0.357 | N/A | N/A | d.58.14 | Ribosomal protein S6 |
| View | Download | 0.353 | N/A | N/A | d.58.5 | GlnB-like |
| View | Download | 0.352 | N/A | N/A | d.58.5 | GlnB-like |
| View | Download | 0.351 | N/A | N/A | d.58.3 | Protease propeptides/inhibitors |
| View | Download | 0.346 | N/A | N/A | d.58.4 | Dimeric alpha+beta barrel |
| View | Download | 0.346 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.344 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.341 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.338 | N/A | N/A | b.1.2 | Fibronectin type III |
| View | Download | 0.329 | N/A | N/A | d.131.1 | DNA clamp |
| View | Download | 0.328 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.327 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.327 | N/A | N/A | d.1.1 | Microbial ribonucleases |
| View | Download | 0.326 | N/A | N/A | d.57.1 | DNA damage-inducible protein DinI |
| View | Download | 0.326 | N/A | N/A | d.15.1 | Ubiquitin-like |
| View | Download | 0.325 | N/A | N/A | d.58.17 | Metal-binding domain |
| View | Download | 0.314 | N/A | N/A | d.74.2 | C-terminal domain of arginine repressor |
| View | Download | 0.311 | N/A | N/A | d.52.1 | Alpha-lytic protease prodomain |
| View | Download | 0.310 | N/A | N/A | d.32.1 | Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase |
| View | Download | 0.306 | N/A | N/A | d.58.24 | CheY-binding domain of CheA |
| View | Download | 0.302 | N/A | N/A | d.206.1 | YggU-like |
| View | Download | 0.300 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.299 | N/A | N/A | d.52.1 | Alpha-lytic protease prodomain |
| View | Download | 0.296 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.290 | N/A | N/A | d.58.3 | Protease propeptides/inhibitors |
| View | Download | 0.285 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.283 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.282 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.280 | N/A | N/A | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.278 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.276 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.276 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.275 | N/A | N/A | d.21.1 | Diaminopimelate epimerase-like |
| View | Download | 0.272 | N/A | N/A | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.271 | N/A | N/A | b.40.2 | Bacterial enterotoxins |
| View | Download | 0.271 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.267 | N/A | N/A | d.58.18 | Regulatory domain in the aminoacid metabolism |
| View | Download | 0.266 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.263 | N/A | N/A | d.32.1 | Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase |
| View | Download | 0.263 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.261 | N/A | N/A | d.150.1 | 4'-phosphopantetheinyl transferase |
| View | Download | 0.259 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.259 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.257 | N/A | N/A | d.1.1 | Microbial ribonucleases |
| View | Download | 0.254 | N/A | N/A | d.58.35 | Pseudouridine synthase |
| View | Download | 0.253 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.248 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.248 | N/A | N/A | d.26.3 | Chitinase insertion domain |
| View | Download | 0.243 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.243 | N/A | N/A | d.206.1 | YggU-like |
| View | Download | 0.242 | N/A | N/A | c.47.1 | Thioredoxin-like |
| View | Download | 0.239 | N/A | N/A | d.58.20 | NAD-binding domain of HMG-CoA reductase |
| View | Download | 0.238 | N/A | N/A | d.74.1 | Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) |
| View | Download | 0.237 | N/A | N/A | a.28.1 | ACP-like |
| View | Download | 0.237 | N/A | N/A | d.58.2 | Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain |
| View | Download | 0.237 | N/A | N/A | d.74.5 | Hypothetical protein Yml108w |
| View | Download | 0.234 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.228 | N/A | N/A | d.13.1 | HIT-like |
| View | Download | 0.226 | N/A | N/A | d.58.24 | CheY-binding domain of CheA |
| View | Download | 0.224 | N/A | N/A | d.58.5 | GlnB-like |
| View | Download | 0.221 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.220 | N/A | N/A | d.32.1 | Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase |
| View | Download | 0.219 | N/A | N/A | b.71.1 | Glycosyl hydrolase domain |
| View | Download | 0.218 | N/A | N/A | d.58.42 | N-utilization substance G protein NusG, N-terminal domain |
| View | Download | 0.216 | N/A | N/A | d.68.7 | R3H domain |
| View | Download | 0.215 | N/A | N/A | d.9.2 | Description not found. |
| View | Download | 0.214 | N/A | N/A | b.40.4 | Nucleic acid-binding proteins |
| View | Download | 0.211 | N/A | N/A | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.207 | N/A | N/A | c.3.1 | FAD/NAD(P)-binding domain |
| View | Download | 0.201 | N/A | N/A | d.26.3 | Chitinase insertion domain |
| Term | Confidence | Notes |
| general RNA polymerase II transcription factor activity | 2.79445416141967 | bayes_pls_golite062009 |
| binding | 2.42570478946173 | bayes_pls_golite062009 |
| transcription regulator activity | 2.3610959773142 | bayes_pls_golite062009 |
| nucleic acid binding | 2.30918780727915 | bayes_pls_golite062009 |
| transcription repressor activity | 2.29049708962212 | bayes_pls_golite062009 |
| DNA binding | 1.71685536470455 | bayes_pls_golite062009 |
| transcription corepressor activity | 1.41752877005447 | bayes_pls_golite062009 |
| protein binding | 1.21879977456466 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.19593750149343 | bayes_pls_golite062009 |
| transcription factor activity | 1.08768505897883 | bayes_pls_golite062009 |
| 0.88172763425403 | bayes_pls_golite062009 | |
| histone binding | 0.685319917508843 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.676924760416604 | bayes_pls_golite062009 |
| actin binding | 0.529861581509437 | bayes_pls_golite062009 |
| transcription factor binding | 0.489473003915035 | bayes_pls_golite062009 |
| snoRNA binding | 0.347797037104681 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.30761651528651 | bayes_pls_golite062009 |
| transporter activity | 0.284701931503833 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.164101908612691 | bayes_pls_golite062009 |
| chromatin binding | 0.151977098745772 | bayes_pls_golite062009 |
| structural molecule activity | 0.0936365746095786 | bayes_pls_golite062009 |
|
Region A: Residues: [86-473] |
1 11 21 31 41 51
| | | | | |
1 EHRLWGYSGW LCRDTNNINS VEKMNSKLLF ECKSPSTITD VKYDINLGIL FVLLSNENKI 60
61 LLFRHKTFDK LSEITIDKAS KPITGIIDPT GQTFTVMTSD RSILVYQINK TGTHKLINKL 120
121 TQHVQMYPLH YRISMSPQAD ILPVINSVKG VPNNATSCTA LLDRNNNYKV TKTLVTPSSN 180
181 GCRVLVYSPA FYEKPNLKKG TSTRYNLIAT SGSTDGTILV WNTKRMKPLF NALQVSSTAI 240
241 NDMSWSQDGF TLFAISNDAT LYTFAFQEKD LGVALPQTEI KSLQEVNKKL PKLEEPLAEQ 300
301 IPKSFPENIK LEESASAAPI PNDIGRSAVG KKPTKKKTAN NQTNGIKTIQ STSMEFNTPS 360
361 YTVPRDLKRK PKEATPSNIA PGSKKQKK
|
| Detection Method: | |
| Confidence: | 70.39794 |
| Match: | 1gg2B_ |
| Description: | beta1-subunit of the signal-transducing G protein heterotrimer |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 5.23858959608048 | bayes_pls_golite062009 |
| DNA binding | 4.78517210147551 | bayes_pls_golite062009 |
| nucleic acid binding | 4.72059012764202 | bayes_pls_golite062009 |
| transcription factor activity | 4.02736190679869 | bayes_pls_golite062009 |
| transcription repressor activity | 3.60278632732466 | bayes_pls_golite062009 |
| binding | 3.37660003833383 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 2.84400558797599 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 2.41045867230388 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 2.21432668306508 | bayes_pls_golite062009 |
| transcription activator activity | 2.13702350917359 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 1.75305601393584 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.795220428630727 | bayes_pls_golite062009 |
| transcription factor binding | 0.752335897765285 | bayes_pls_golite062009 |
| protein binding | 0.726445167461826 | bayes_pls_golite062009 |
| specific transcriptional repressor activity | 0.710995647413393 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 0.490809930581315 | bayes_pls_golite062009 |
| transcription corepressor activity | 0.252392400929265 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.224230323813474 | bayes_pls_golite062009 |
| structural molecule activity | 0.128347187436068 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity, enhancer binding | 0.0406721670764369 | bayes_pls_golite062009 |
|
Region A: Residues: [474-698] |
1 11 21 31 41 51
| | | | | |
1 ELQPIDFLDT GLLLPNTSFS RIRLATPKIR STFKYSPINN PNLILDVKNG SGNEQRPTIV 60
61 KLTSKVLDQD QVLFQDFIPK LITICTAGDT FWSFCSEDGS IYIYSDSGRK LMAPLVLGVS 120
121 ISFLEACGTY LLCLTSIGEL YCWNIEQKKL AFPTNTIYPL LNPSLRYSDD ILTRAENITL 180
181 CSITKKGVPL VTLSNGDGYL FDKNMETWLL VSDGWWAYGS QYWDT
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [699-752] |
1 11 21 31 41 51
| | | | | |
1 TNTTGLSSSK ANTDSFNGSE SNINEIVSDI KNDNQSIINF LECKTNDELN RKGR
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.300 | a.5.2 | UBA-like |
| View | Download | 0.524 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.319 | a.37.1 | A DNA-binding domain in eukaryotic transcription factors |
| View | Download | 0.439 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.295 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.291 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.281 | a.5.2 | UBA-like |
| View | Download | 0.268 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.268 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.260 | a.4.11 | RNA polymerase subunit RPB10 |
| View | Download | 0.239 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.238 | a.5.2 | UBA-like |
| View | Download | 0.235 | a.37.1 | A DNA-binding domain in eukaryotic transcription factors |
| View | Download | 0.230 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.221 | a.37.1 | A DNA-binding domain in eukaryotic transcription factors |
| View | Download | 0.219 | a.5.7 | 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain |
| View | Download | 0.209 | a.5.7 | 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain |
| View | Download | 0.209 | a.5.2 | UBA-like |
| View | Download | 0.203 | b.40.4 | Nucleic acid-binding proteins |
|
Region A: Residues: [753-875] |
1 11 21 31 41 51
| | | | | |
1 IKNLQRFART ILMKEGFENM EEIVTLSHLE NKILISIRLE EPEEFSKLMM VYCIRLSELG 60
61 YMDRLNDVFQ WLYDDLPISG TGSAFADKDF KRNLLKKILI ACGDIRQVQR VTTRYAKEMN 120
121 IIS
|
| Detection Method: | |
| Confidence: | 7.63 |
| Match: | 1bgxT |
| Description: | 5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment) |
Matching Structure (courtesy of the PDB): |
|
