YRC Public Data Repository - Protein Structure Prediction

Protein:	HST3
Organism:	Saccharomyces cerevisiae
Length:	447 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HST3.

Description	E-value	Query Range	Subject Range
HST3 - Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in tel... HST3_YEAST - NAD-dependent histone deacetylase HST3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=H...	0.0	[1..447]	[1..447]
SIRT1 - sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)	2.0E-76	[20..390]	[215..536]
SIR1_MOUSE - NAD-dependent protein deacetylase sirtuin-1 OS=Mus musculus GN=Sirt1 PE=1 SV=2 gi\|183396975 - gi\|183396975\|gb\|AAI65995.1\| Sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. c...	2.0E-74	[20..390]	[207..528]
sir-2.1 - Yeast regulatory protein SIR2 like status:Partially_confirmed UniProt:Q21921 protein_id:CAA94364.1	2.0E-73	[6..378]	[97..420]
gi\|3928792 - gi\|3928792\|gb\|AAC79684.1\| SIR2 [Drosophila melanogaster]	5.0E-73	[16..342]	[177..482]

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Predicted Domain #1

Region A:
Residues: [1-71]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSVSPSPPA SRSGSMCSDL PSSLQTEKLA HIIGLDADDE VLRRVTKQLS RSRRIACLTG  60
   61 AGISCNAGIP D

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [122-189]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNVQLAKPTK THKFIAHLKD RNKLLRCYTQ NIDGLEESIG LTLSNRKLPL TSFSSHWKNL  60
   61 DVVQLHGD

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [257-392]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSCEIITQGL NLDIIKGNPD FLIIMGTSLK VDGVKQLVKK LSKKIHDRGG LIILVNKTPI  60
   61 GESSWHGIID YQIHSDCDNW VTFLESQIPD FFKTQDQIKK LRQLKREASD LRKQMKAQKD 120
  121 SIGTPPTTPL RTAQGI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	317.221849
Match:	1j8fA_
Description:	Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	9.15022242957651	bayes_pls_golite062009
histone deacetylase activity	9.04876491350231	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	8.13038616303736	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	8.13038616303736	bayes_pls_golite062009
deacetylase activity	8.11496387956068	bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific)	6.02509672218091	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	5.83127897351395	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K9 specific)	4.76068488405318	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K14 specific)	4.76068488405318	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H4-K16 specific)	4.51070381823692	bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific)	3.4896257195243	bayes_pls_golite062009
transcription regulator activity	2.9155913558118	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	2.82468859281133	bayes_pls_golite062009
DNA binding	2.43141001866996	bayes_pls_golite062009
nucleic acid binding	2.41433477472968	bayes_pls_golite062009
transcription repressor activity	2.24657784428979	bayes_pls_golite062009
binding	2.06552694538163	bayes_pls_golite062009
histone binding	1.71445510915336	bayes_pls_golite062009
transcription corepressor activity	1.64212790017753	bayes_pls_golite062009
nucleosome binding	1.5125174755597	bayes_pls_golite062009
transcription factor activity	1.30143289828088	bayes_pls_golite062009
transcription factor binding	1.14766678956419	bayes_pls_golite062009
tubulin deacetylase activity	1.11434618720209	bayes_pls_golite062009
catalytic activity	0.739210399081789	bayes_pls_golite062009
transcription cofactor activity	0.54005617175343	bayes_pls_golite062009
transferase activity	0.483523935618287	bayes_pls_golite062009
protein binding	0.475479132768057	bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity	0.0099486881187274	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [72-121]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRSSDGLYDL VKKDCSQYWS IKSGREMFDI SLFRDDFKIS IFAKFMERLY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [190-256]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKTLSCTKCF QTFPWSRYWS RCLRRGELPL CPDCEALINK RLNEGKRTLG SNVGILRPNI  60
   61 VLYGENH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	317.221849
Match:	1j8fA_
Description:	Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [393-447]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIQGNNELNT KIKSLNTVKR KILSPENSSE EDEEENLDTR KRAKIRPTFG DNQAS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.484	0.956	chromatin silencing at telomere	a.4.1	Homeodomain-like
View	Download	0.248	0.956	chromatin silencing at telomere	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.275	0.956	chromatin silencing at telomere	f.14.1	Voltage-gated potassium channels
View	Download	0.299	0.956	chromatin silencing at telomere	a.4.1	Homeodomain-like
View	Download	0.231	0.956	chromatin silencing at telomere	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.219	0.956	chromatin silencing at telomere	a.4.13	Sigma3 and sigma4 domains of RNA polymerase sigma factors
View	Download	0.206	0.956	chromatin silencing at telomere	a.4.1	Homeodomain-like
View	Download	0.205	0.956	chromatin silencing at telomere	d.66.1	Alpha-L RNA-binding motif

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: