YRC Public Data Repository - Protein Structure Prediction

Protein:	YOL098C
Organism:	Saccharomyces cerevisiae
Length:	1037 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YOL098C.

Description	E-value	Query Range	Subject Range
YOL098C - Putative metalloprotease YO098_YEAST - Uncharacterized protein YOL098C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YOL098C ...	0.0	[1..1017]	[1..1017]
gi\|13477137 - gi\|13477137\|gb\|AAH05025.1\| Pitrilysin metallopeptidase 1 [Homo sapiens]	0.0	[10..1002]	[53..1030]
SPAC3H1.02c - metallopeptidase YAN2_SCHPO - Uncharacterized protein C3H1.02c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC3H1.0...	0.0	[8..1034]	[10..1027]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[15..1027]	[20..974]
IDE1_ARATH - Insulin-degrading enzyme-like 1, peroxisomal OS=Arabidopsis thaliana GN=PXM16 PE=2 SV=1	0.0	[21..1022]	[26..949]
gi\|7190249, gi\|1... - gi\|7190249\|gb\|AAF39083.1\| metalloprotease, insulinase family [Chlamydia muridarum Nigg], gi\|15834831... gi\|7190249, gi\|1... - gi\|7190249\|gb\|AAF39083.1\| metalloprotease, insulinase family [Chlamydia muridarum Nigg], gi\|15834831...	0.0	[4..1018]	[12..972]
gi\|237803256, gi... - gi\|237803256\|ref\|YP_002888450.1\| metalloprotease-insulinase [Chlamydia trachomatis], gi\|231274490\|em... gi\|3329294, gi\|1... - gi\|3329294\|gb\|AAC68421.1\| Zinc Metalloprotease (insulinase family) [Chlamydia trachomatis D/UW-3/CX]... gi\|7469080 - pir\|\|A71466 probable zinc metalloproteinase (insulinase family) - Chlamydia trachomatis (serotype D,... gi\|76168099, gi\|... - gi\|76789569\|ref\|YP_328655.1\| insulinase family metalloprotease [Chlamydia trachomatis A/HAR-13], gi\|...	0.0	[4..1018]	[12..971]
IDE_RAT - Insulin-degrading enzyme OS=Rattus norvegicus GN=Ide PE=1 SV=1	0.0	[10..997]	[57..958]

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Predicted Domain #1

Region A:
Residues: [1-158]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFKKLVSFQ PDYVPQYHIT KYISERTKLQ LVHINHKTSP LVHGYFAVPT ECLNDSGAPH  60
   61 TLEHLIFMGS KSYPYKGLLD TAGNLSLSNT NAWTDTDQTV YTLSSAGWKG FSKLLPAYLD 120
  121 HILHPTLTDE ACLTEVYHID PENLGDKGVV FSEMEAIE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [179-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYRSETGGLT KNLRTLTNDE IRQFHKSLYS SDNLCVIVCG NVPTDELLTV MEEWDNKLPE  60
   61 IPSNIPKKRP FLDNKLSHIP QS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [387-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNYEKNGESR FSSAVITDYI YGNEDGSSLV SSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	130.221849
Match:	1bccA_
Description:	Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.69244584360647	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.08483676722061	bayes_pls_golite062009
endopeptidase activity	2.95066280153013	bayes_pls_golite062009
hydrolase activity	2.42559068821325	bayes_pls_golite062009
metallopeptidase activity	2.13305051098292	bayes_pls_golite062009
metalloendopeptidase activity	1.79244321225531	bayes_pls_golite062009
binding	1.51460850438647	bayes_pls_golite062009
catalytic activity	1.30647052031202	bayes_pls_golite062009
structural molecule activity	0.389336364351523	bayes_pls_golite062009
protein binding	0.236143103582996	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [159-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQGWYISGLE KQRLMFPEGS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [261-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDKVTESTVE FPELDESQGE LLFSWIGVPY SDFRNDLAVD VLLDYFTDSA LAVFTRELVE  60
   61 IDDPMANSTD CCTDYFMRTI IDLRIQGVPT EKIAATKTKV LEILKTHTID LSRVRQVVEN 120
  121 TKWEYL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [420-498]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDLSDFDALL QWSQKDWQSL LNRIFVDNKP IIVTAKPSAL MYEQLEKEKS DLIKQREAEF  60
   61 DDEKKLVLLK RLNNAKNIN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	130.221849
Match:	1bccA_
Description:	Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [499-550]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRPIPKSLLQ KFEIDNPSKS VEFVNTKSIA TVDSYKYNNV SDPLTKKILE TR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [551-689]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDNFPLFIHL NHFPSQFIEL HFLVNSASIK DTSLLPYFNM FDELFSMPMK ILDEESNVET  60
   61 MLSFEEVVAK LKSETIDAQI NQGLKGSCPD LINFKIQCRA GGYSNSVQWI KHCLFDMVFD 120
  121 ENRVRILLEN YLNSIVEWK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [708-793]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSLKKSTDPL FVEAKLQEIF AEIENGNFEK EILPRIETMR KQLRANFNKF HILVLGDISK  60
   61 IDDVYEPWNP LIKCLNIAHP VEKLKI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [935-960]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IECGYFETAL SKYVDEFCLQ RGNNFN

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.21
Match:	1kb9A
Description:	Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [690-707]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNGNVMLSSL TNRNLYSA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [794-934]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPVPRALDTI SSICRTPGEK AFIITTPASE SAYMNLITSI PFNLDYHDPE YAIVSLASEY  60
   61 LECVEGPFWK GIRGAGLAYG ASMLKLCEIN SWGFNIYRGA DIIKCYEVGK QIVQDYASGA 120
  121 LEFDEQLIQG AISSIINRLA T

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [961-1037]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELYLERLQNV TKTDLKNAMQ KYFVNMFDSN KSVAFVSCHP AKLESVQEFF ETQGFTVEIE  60
   61 ELEDDDDEID SEEDENA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.21
Match:	1kb9A
Description:	Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: