YRC Public Data Repository - Protein Structure Prediction

Protein:	YOL098C
Organism:	Saccharomyces cerevisiae
Length:	1037 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YOL098C.

Description	E-value	Query Range	Subject Range
YOL098C - Putative metalloprotease YO098_YEAST - Uncharacterized protein YOL098C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YOL098C ...	0.0	[1..1017]	[1..1017]
gi\|13477137 - gi\|13477137\|gb\|AAH05025.1\| Pitrilysin metallopeptidase 1 [Homo sapiens]	0.0	[10..1002]	[53..1030]
SPAC3H1.02c - metallopeptidase YAN2_SCHPO - Uncharacterized protein C3H1.02c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC3H1.0...	0.0	[8..1034]	[10..1027]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[15..1027]	[20..974]
IDE1_ARATH - Insulin-degrading enzyme-like 1, peroxisomal OS=Arabidopsis thaliana GN=PXM16 PE=2 SV=1	0.0	[21..1022]	[26..949]
gi\|7190249, gi\|1... - gi\|7190249\|gb\|AAF39083.1\| metalloprotease, insulinase family [Chlamydia muridarum Nigg], gi\|15834831... gi\|7190249, gi\|1... - gi\|7190249\|gb\|AAF39083.1\| metalloprotease, insulinase family [Chlamydia muridarum Nigg], gi\|15834831...	0.0	[4..1018]	[12..972]
gi\|237803256, gi... - gi\|237803256\|ref\|YP_002888450.1\| metalloprotease-insulinase [Chlamydia trachomatis], gi\|231274490\|em... gi\|3329294, gi\|1... - gi\|3329294\|gb\|AAC68421.1\| Zinc Metalloprotease (insulinase family) [Chlamydia trachomatis D/UW-3/CX]... gi\|7469080 - pir\|\|A71466 probable zinc metalloproteinase (insulinase family) - Chlamydia trachomatis (serotype D,... gi\|76168099, gi\|... - gi\|76789569\|ref\|YP_328655.1\| insulinase family metalloprotease [Chlamydia trachomatis A/HAR-13], gi\|...	0.0	[4..1018]	[12..971]
IDE_RAT - Insulin-degrading enzyme OS=Rattus norvegicus GN=Ide PE=1 SV=1	0.0	[10..997]	[57..958]

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Predicted Domain #1

Region A:
Residues: [1-158]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFKKLVSFQ PDYVPQYHIT KYISERTKLQ LVHINHKTSP LVHGYFAVPT ECLNDSGAPH  60
   61 TLEHLIFMGS KSYPYKGLLD TAGNLSLSNT NAWTDTDQTV YTLSSAGWKG FSKLLPAYLD 120
  121 HILHPTLTDE ACLTEVYHID PENLGDKGVV FSEMEAIE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [179-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYRSETGGLT KNLRTLTNDE IRQFHKSLYS SDNLCVIVCG NVPTDELLTV MEEWDNKLPE  60
   61 IPSNIPKKRP FLDNKLSHIP QS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [387-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNYEKNGESR FSSAVITDYI YGNEDGSSLV SSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	130.221849
Match:	1bccA_
Description:	Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.69244584360647	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.08483676722061	bayes_pls_golite062009
endopeptidase activity	2.95066280153013	bayes_pls_golite062009
hydrolase activity	2.42559068821325	bayes_pls_golite062009
metallopeptidase activity	2.13305051098292	bayes_pls_golite062009
metalloendopeptidase activity	1.79244321225531	bayes_pls_golite062009
binding	1.51460850438647	bayes_pls_golite062009
catalytic activity	1.30647052031202	bayes_pls_golite062009
structural molecule activity	0.389336364351523	bayes_pls_golite062009
protein binding	0.236143103582996	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [159-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQGWYISGLE KQRLMFPEGS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [261-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDKVTESTVE FPELDESQGE LLFSWIGVPY SDFRNDLAVD VLLDYFTDSA LAVFTRELVE  60
   61 IDDPMANSTD CCTDYFMRTI IDLRIQGVPT EKIAATKTKV LEILKTHTID LSRVRQVVEN 120
  121 TKWEYL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [420-498]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDLSDFDALL QWSQKDWQSL LNRIFVDNKP IIVTAKPSAL MYEQLEKEKS DLIKQREAEF  60
   61 DDEKKLVLLK RLNNAKNIN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	130.221849
Match:	1bccA_
Description:	Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [499-550]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRPIPKSLLQ KFEIDNPSKS VEFVNTKSIA TVDSYKYNNV SDPLTKKILE TR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.339	d.58.17	Metal-binding domain
View	Download	0.394	g.3.11	EGF/Laminin
View	Download	0.375	d.51.1	Eukaryotic type KH-domain (KH-domain type I)
View	Download	0.492	d.9.2	Description not found.
View	Download	0.312	d.58.17	Metal-binding domain
View	Download	0.309	a.60.1	SAM/Pointed domain
View	Download	0.294	g.3.11	EGF/Laminin
View	Download	0.287	d.58.23	Probable ACP-binding domain of malonyl-CoA ACP transacylase
View	Download	0.270	d.9.2	Description not found.
View	Download	0.261	d.9.2	Description not found.
View	Download	0.256	g.37.1	C2H2 and C2HC zinc fingers
View	Download	0.248	b.34.2	SH3-domain
View	Download	0.237	d.9.1	Interleukin 8-like chemokines
View	Download	0.231	d.52.5	Probable GTPase Der, C-terminal domain
View	Download	0.226	g.3.11	EGF/Laminin
View	Download	0.225	g.3.11	EGF/Laminin
View	Download	0.219	d.58.23	Probable ACP-binding domain of malonyl-CoA ACP transacylase
View	Download	0.214	d.58.7	RNA-binding domain, RBD
View	Download	0.211	a.60.2	RuvA domain 2-like
View	Download	0.209	a.60.11	Hypothetical protein YjbJ
View	Download	0.205	a.44.1	Disulphide-bond formation facilitator (DSBA), insertion domain
View	Download	0.204	d.58.40	D-ribose-5-phosphate isomerase (RpiA), lid domain
View	Download	0.201	d.52.1	Alpha-lytic protease prodomain

Predicted Domain #4

Region A:
Residues: [551-689]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDNFPLFIHL NHFPSQFIEL HFLVNSASIK DTSLLPYFNM FDELFSMPMK ILDEESNVET  60
   61 MLSFEEVVAK LKSETIDAQI NQGLKGSCPD LINFKIQCRA GGYSNSVQWI KHCLFDMVFD 120
  121 ENRVRILLEN YLNSIVEWK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [708-793]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSLKKSTDPL FVEAKLQEIF AEIENGNFEK EILPRIETMR KQLRANFNKF HILVLGDISK  60
   61 IDDVYEPWNP LIKCLNIAHP VEKLKI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [935-960]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IECGYFETAL SKYVDEFCLQ RGNNFN

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.21
Match:	1kb9A
Description:	Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [690-707]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNGNVMLSSL TNRNLYSA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [794-934]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPVPRALDTI SSICRTPGEK AFIITTPASE SAYMNLITSI PFNLDYHDPE YAIVSLASEY  60
   61 LECVEGPFWK GIRGAGLAYG ASMLKLCEIN SWGFNIYRGA DIIKCYEVGK QIVQDYASGA 120
  121 LEFDEQLIQG AISSIINRLA T

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [961-1037]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELYLERLQNV TKTDLKNAMQ KYFVNMFDSN KSVAFVSCHP AKLESVQEFF ETQGFTVEIE  60
   61 ELEDDDDEID SEEDENA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.21
Match:	1kb9A
Description:	Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: