YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: YNL247W
Organism: Saccharomyces cerevisiae
Length: 767 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YNL247W.

Description E-value Query
Range		 Subject
Range
YNL247W - Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments
SYC_YEAST - Cysteine--tRNA ligase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YNL247W PE=1 SV=1
 0.0 [1..767] [1..767]
gi|123979740, gi... - gi|60655925|gb|AAX32526.1| cysteinyl-tRNA synthetase [synthetic construct], gi|123979740|gb|ABM81699...
CARS - cysteinyl-tRNA synthetase
 0.0 [18..763] [12..739]
SYCC_MOUSE - Cysteine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Cars PE=1 SV=2
 0.0 [18..763] [95..822]
gi|11191800 - gi|11191800|emb|CAC16398.1| Cysteinyl-tRNA-synthetase [Mus musculus domesticus]
gi|148686272 - gi|148686272|gb|EDL18219.1| cysteinyl-tRNA synthetase, isoform CRA_a [Mus musculus]
 0.0 [18..763] [95..822]
SYC_SCHPO - Probable cysteine--tRNA ligase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC29E6.06...
SPAC29E6.06c - cysteine-tRNA ligase
 0.0 [14..763] [1..746]
crs-1 - aminoacyl-tRNA synthetase status:Partially_confirmed UniProt:O76618 protein_id:AAC64633.1
 0.0 [18..761] [166..909]

Back

Predicted Domain #1
Region A:
Residues: [1-153] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIFIKALRR YTIMSTPKIV QPKWKVPTPQ AKETVLKLYN SLTRSKVEFI PQSGNRGVTW  60
   61 YSCGPTVYDA SHMGHARNYV SIDINRRIIQ DYFGYDVQFV QNVTDIDDKI ILRARQNYLF 120
  121 DNFVKENDTK FNATVVDKVK TALFQYINKN FTI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.045757
Match: 1lleA_
Description: No description for 1lleA_ was found.

Predicted Domain #2
Region A:
Residues: [154-419] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGSEIKTIEE FETWLSNADT ETLKLENPKF PMHVTAVQNA IESITKGDSM DAEVAFEKVK  60
   61 DVTVPLLDKE LGSTISNPEI FRQLPAYWEQ KFNDDMLSLN VLPPTVTTRV SEYVPEIIDF 120
  121 VQKIIDNGYA YATSDGSVYF DTLKFDKSPN HDYAKCQPWN KGQLDLINDG EGSLSNFADN 180
  181 GKKSNNDFAL WKASKAGEPE WESPWGKGRP GWHIECSVMA SDILGSNIDI HSGGIDLAFP 240
  241 HHDNELAQSE ARFDNQQWIN YFLHTG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 588.54902
Match: 1li5A_
Description: Cysteinyl-tRNA synthetase (CysRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming aminoacyl-tRNA and related compounds 7.16276509815667 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 7.16276509815667 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.13957775963187 bayes_pls_golite062009
ligase activity 6.11211476973434 bayes_pls_golite062009
cysteine-tRNA ligase activity 5.23703961447809 bayes_pls_golite062009
isoleucine-tRNA ligase activity 3.76808520367507 bayes_pls_golite062009
glutamate-tRNA ligase activity 2.63681738794687 bayes_pls_golite062009
catalytic activity 2.37674226834122 bayes_pls_golite062009
methionine-tRNA ligase activity 2.01261843164558 bayes_pls_golite062009
tyrosine-tRNA ligase activity 1.88984817882585 bayes_pls_golite062009
tryptophan-tRNA ligase activity 1.14187887833901 bayes_pls_golite062009
arginine-tRNA ligase activity 1.13743634264647 bayes_pls_golite062009
nucleotidyltransferase activity 0.89131347796645 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.625793556381714 bayes_pls_golite062009
nucleic acid binding 0.369886886936128 bayes_pls_golite062009
RNA binding 0.306683553109855 bayes_pls_golite062009
glutamine-tRNA ligase activity 0.118292082006187 bayes_pls_golite062009
binding 0.090743795600025 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [420-474] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLHIEGQKMS KSLKNFITIQ EALKKFSPRQ LRLAFASVQW NNQLDFKESL IHEVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 588.54902
Match: 1li5A_
Description: Cysteinyl-tRNA synthetase (CysRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [475-664] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFENSMNNFF KTIRALKNDA ASAGHISKKF SPLEKELLAD FVESESKVHS AFCDNLSTPV  60
   61 ALKTLSELVT KSNTYITTAG AALKIEPLIA ICSYITKILR IIGFPSRPDN LGWAAQAGSN 120
  121 DGSLGSLEDT VMPYVKCLST FRDDVRSLAI KKAEPKEFLQ LTDKIRNEDL LNLNVALDDR 180
  181 NGQSALIKFL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 588.54902
Match: 1li5A_
Description: Cysteinyl-tRNA synthetase (CysRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [665-767] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNDEKLEIVK LNEEKHANEL AKKQKKLEQQ KLREQKENER KQKAQIKPQD MFKDVTLYSA  60
   61 WDEQGLPTKD KDGNDITKSM TKKLKKQWEQ QKKLHEEYFG EDK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.585 a.40.1 Calponin-homology domain, CH-domain
View Download 0.555 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.531 c.10.1 RNI-like
View Download 0.738 a.24.4 Hemerythrin
View Download 0.557 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.490 a.74.1 Cyclin-like
View Download 0.470 d.54.1 Enolase N-terminal domain-like
View Download 0.460 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.444 a.156.1 S13-like H2TH domain
View Download 0.432 d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.413 a.156.1 S13-like H2TH domain
View Download 0.405 a.24.3 Cytochromes
View Download 0.405 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.388 d.2.1 Lysozyme-like
View Download 0.387 a.156.1 S13-like H2TH domain
View Download 0.379 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.374 a.130.1 Chorismate mutase II
View Download 0.374 a.74.1 Cyclin-like
View Download 0.366 a.167.1 Porin chaperone SurA, peptide-binding domain
View Download 0.357 a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.356 a.156.1 S13-like H2TH domain
View Download 0.356 b.40.4 Nucleic acid-binding proteins
View Download 0.349 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.343 a.75.1 Ribosomal protein S7
View Download 0.342 d.201.1 SRP19
View Download 0.327 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.327 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.323 a.144.1 PABC (PABP) domain
View Download 0.311 a.74.1 Cyclin-like
View Download 0.302 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.300 a.74.1 Cyclin-like
View Download 0.297 a.167.1 Porin chaperone SurA, peptide-binding domain
View Download 0.292 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.291 a.74.1 Cyclin-like
View Download 0.287 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.281 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.279 a.22.1 Histone-fold
View Download 0.278 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.277 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.277 d.2.1 Lysozyme-like
View Download 0.275 a.22.1 Histone-fold
View Download 0.274 d.2.1 Lysozyme-like
View Download 0.273 a.39.1 EF-hand
View Download 0.270 a.24.9 alpha-catenin/vinculin
View Download 0.268 a.24.9 alpha-catenin/vinculin
View Download 0.267 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.267 d.129.1 TATA-box binding protein-like
View Download 0.264 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.262 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.260 a.156.1 S13-like H2TH domain
View Download 0.260 c.55.3 Ribonuclease H-like
View Download 0.259 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.259 d.50.1 dsRNA-binding domain-like
View Download 0.255 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.255 a.75.1 Ribosomal protein S7
View Download 0.250 d.54.1 Enolase N-terminal domain-like
View Download 0.250 d.201.1 SRP19
View Download 0.243 i.11.1 Computational models partly based on NMR data
View Download 0.239 d.2.1 Lysozyme-like
View Download 0.236 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.234 d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.233 a.24.4 Hemerythrin
View Download 0.233 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.233 a.4.1 Homeodomain-like
View Download 0.229 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.229 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.228 a.74.1 Cyclin-like
View Download 0.227 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.226 a.156.1 S13-like H2TH domain
View Download 0.225 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.224 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.219 a.24.17 Group V grass pollen allergen
View Download 0.218 d.201.1 SRP19
View Download 0.217 a.1.1 Globin-like
View Download 0.215 a.25.1 Ferritin-like
View Download 0.215 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.211 d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.211 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.208 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.207 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.207 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.207 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.207 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.206 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.206 a.1.1 Globin-like
View Download 0.206 a.39.1 EF-hand
View Download 0.205 a.25.1 Ferritin-like
View Download 0.205 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.201 a.74.1 Cyclin-like
View Download 0.200 a.4.5 "Winged helix" DNA-binding domain

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle