YRC Public Data Repository - Protein Structure Prediction

Protein:	YLR143W
Organism:	Saccharomyces cerevisiae
Length:	685 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLR143W.

Description	E-value	Query Range	Subject Range
DPH6_YEAST - Diphthine--ammonia ligase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DPH6 PE=1 SV=1 YLR143W - Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to th... gi\|190406171 - gi\|190406171\|gb\|EDV09438.1\| hypothetical protein SCRG_05121 [Saccharomyces cerevisiae RM11-1a] gi\|151941304 - gi\|151941304\|gb\|EDN59682.1\| conserved protein [Saccharomyces cerevisiae YJM789]	0.0	[1..685]	[1..685]
mug71 - endoribonuclease DPH6_SCHPO - Diphthine--ammonia ligase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mug71 PE=1 SV=1	0.0	[1..583]	[1..536]
gi\|10728196, gi\|... - ref\|NP_572749.1\| CG1578-PA [Drosophila melanogaster], gb\|AAF48097.2\| CG1578-PA [Drosophila melanogas...	0.0	[1..571]	[1..544]
gi\|7547107, gi\|1... - gi\|7547107\|gb\|AAF63779.1\| unknown protein [Arabidopsis thaliana], gi\|15229304\|ref\|NP_187098.1\| endor...	0.0	[1..587]	[1..564]
DPH6_MOUSE - Diphthine--ammonia ligase OS=Mus musculus GN=Dph6 PE=1 SV=1	6.0E-91	[1..274]	[1..255]
gi\|119612733, gi... - gi\|45219851\|gb\|AAH66652.1\| ATP binding domain 4 [Homo sapiens], gi\|21752980\|dbj\|BAC04266.1\| unnamed ...	8.0E-91	[1..274]	[1..255]
gi\|90109172, gi\|... - gi\|90109175\|pdb\|2D13\|D Chain D, Crystal Structure Of Ph1257 From Pyrococcus Horikoshii Ot3, gi\|90109... gi\|3257676, gi\|1... - gi\|3257676\|dbj\|BAA30359.1\| 227aa long hypothetical protein [Pyrococcus horikoshii OT3], gi\|14591076\|...	2.0E-70	[3..256]	[7..226]
Y570_METJA - Uncharacterized protein MJ0570 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-... Y570_METJA - Uncharacterized protein MJ0570 OS=Methanocaldococcus jannaschii GN=MJ0570 PE=4 SV=1	5.0E-70	[1..255]	[1..220]
gi\|18892857, gi\|... - gi\|18977200\|ref\|NP_578557.1\| n-type ATP pyrophosphatase superfamily protein [Pyrococcus furiosus DSM...	6.0E-70	[3..270]	[7..224]

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Predicted Domain #1

Region A:
Residues: [1-159]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFIALISGG KDSFYNIFHC LKNNHELIAL GNIYPKESEE QELDSFMFQT VGHDLIDYYS  60
   61 KCIGVPLFRR SILRNTSNNV ELNYTATQDD EIEELFELLR TVKDKIPDLE AVSVGAILSS 120
  121 YQRTRVENVC SRLGLVVLSY LWQRDQAELM GEMCLMSKD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.59
Match:	1kh1A
Description:	Argininosuccinate synthetase, N-terminal domain; Argininosuccinate synthetase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity	2.99185607397345	bayes_pls_golite062009
nucleic acid binding	1.14663773925119	bayes_pls_golite062009
DNA binding	0.992954560970173	bayes_pls_golite062009
catalytic activity	0.828867994386867	bayes_pls_golite062009
binding	0.752095595503409	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [160-279]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNNVENDTNS GNKFDARIIK VAAIGLNEKH LGMSLPMMQP VLQKLNQLYQ VHICGEGGEF  60
   61 ETMVLDAPFF QHGYLELIDI VKCSDGEVHN ARLKVKFQPR NLSKSFLLNQ LDQLPVPSIF 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	11.275724
Match:	PF01902
Description:	ATP-binding region

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [280-426]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNNWQDLTQN LPKQQAKTGE QRFENHMSNA LPQTTINKTN DKLYISNLQS RKSETVEKQS  60
   61 EDIFTELADI LHSNQIPRNH ILSASLLIRD MSNFGKINKI YNEFLDLSKY GPLPPSRACV 120
  121 GSKCLPEDCH VQLSVVVDVK NTGKEKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	102.751666
Match:	1qd9A_
Description:	Purine regulatory protein YabJ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribonuclease activity	2.55513289511254	bayes_pls_golite062009
nuclease activity	1.95684086528131	bayes_pls_golite062009
endonuclease activity	1.93161199243014	bayes_pls_golite062009
binding	1.28584712198396	bayes_pls_golite062009
endoribonuclease activity	1.18839679198466	bayes_pls_golite062009
catalytic activity	1.00848565859536	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.659253495197665	bayes_pls_golite062009
hydrolase activity	0.213547115506972	bayes_pls_golite062009
protein binding	0.126122948490201	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [427-587]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKNKGGLHVQ GRSYWAPCNI GPYSQSTWLN DDANQVSFIS GQIGLVPQSM EILGTPLTDQ  60
   61 IVLALQHFDT LCETIGAQEK LLMTCYISDE SVLDSVIKTW AFYCSNMNHR SDLWMDKSDD 120
  121 VEKCLVLVKI SELPRGAVAE FGGVTCKRLI VDDNDSDKKE R

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [588-685]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EENDDVSTVF QKLNLNIEGF HNTTVSAFGY NRNFITGFVD SREELELILE KTPKSAQITL  60
   61 YYNPKEIITF HHHIGYYPVE KLFDYRGKEH RFGLHIRS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.748	0.909	cytoplasm	c.37.1	P-loop containing nucleoside triphosphate hydrolases

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: