YRC Public Data Repository - Protein Structure Prediction

Protein:	YLR143W
Organism:	Saccharomyces cerevisiae
Length:	685 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLR143W.

Description	E-value	Query Range	Subject Range
DPH6_YEAST - Diphthine--ammonia ligase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DPH6 PE=1 SV=1 YLR143W - Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to th... gi\|190406171 - gi\|190406171\|gb\|EDV09438.1\| hypothetical protein SCRG_05121 [Saccharomyces cerevisiae RM11-1a] gi\|151941304 - gi\|151941304\|gb\|EDN59682.1\| conserved protein [Saccharomyces cerevisiae YJM789]	0.0	[1..685]	[1..685]
mug71 - endoribonuclease DPH6_SCHPO - Diphthine--ammonia ligase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mug71 PE=1 SV=1	0.0	[1..583]	[1..536]
gi\|10728196, gi\|... - ref\|NP_572749.1\| CG1578-PA [Drosophila melanogaster], gb\|AAF48097.2\| CG1578-PA [Drosophila melanogas...	0.0	[1..571]	[1..544]
gi\|7547107, gi\|1... - gi\|7547107\|gb\|AAF63779.1\| unknown protein [Arabidopsis thaliana], gi\|15229304\|ref\|NP_187098.1\| endor...	0.0	[1..587]	[1..564]
DPH6_MOUSE - Diphthine--ammonia ligase OS=Mus musculus GN=Dph6 PE=1 SV=1	6.0E-91	[1..274]	[1..255]
gi\|119612733, gi... - gi\|45219851\|gb\|AAH66652.1\| ATP binding domain 4 [Homo sapiens], gi\|21752980\|dbj\|BAC04266.1\| unnamed ...	8.0E-91	[1..274]	[1..255]
gi\|90109172, gi\|... - gi\|90109175\|pdb\|2D13\|D Chain D, Crystal Structure Of Ph1257 From Pyrococcus Horikoshii Ot3, gi\|90109... gi\|3257676, gi\|1... - gi\|3257676\|dbj\|BAA30359.1\| 227aa long hypothetical protein [Pyrococcus horikoshii OT3], gi\|14591076\|...	2.0E-70	[3..256]	[7..226]
Y570_METJA - Uncharacterized protein MJ0570 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-... Y570_METJA - Uncharacterized protein MJ0570 OS=Methanocaldococcus jannaschii GN=MJ0570 PE=4 SV=1	5.0E-70	[1..255]	[1..220]
gi\|18892857, gi\|... - gi\|18977200\|ref\|NP_578557.1\| n-type ATP pyrophosphatase superfamily protein [Pyrococcus furiosus DSM...	6.0E-70	[3..270]	[7..224]

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Predicted Domain #1

Region A:
Residues: [1-159]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFIALISGG KDSFYNIFHC LKNNHELIAL GNIYPKESEE QELDSFMFQT VGHDLIDYYS  60
   61 KCIGVPLFRR SILRNTSNNV ELNYTATQDD EIEELFELLR TVKDKIPDLE AVSVGAILSS 120
  121 YQRTRVENVC SRLGLVVLSY LWQRDQAELM GEMCLMSKD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.59
Match:	1kh1A
Description:	Argininosuccinate synthetase, N-terminal domain; Argininosuccinate synthetase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity	2.99185607397345	bayes_pls_golite062009
nucleic acid binding	1.14663773925119	bayes_pls_golite062009
DNA binding	0.992954560970173	bayes_pls_golite062009
catalytic activity	0.828867994386867	bayes_pls_golite062009
binding	0.752095595503409	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [160-279]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNNVENDTNS GNKFDARIIK VAAIGLNEKH LGMSLPMMQP VLQKLNQLYQ VHICGEGGEF  60
   61 ETMVLDAPFF QHGYLELIDI VKCSDGEVHN ARLKVKFQPR NLSKSFLLNQ LDQLPVPSIF 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	11.275724
Match:	PF01902
Description:	ATP-binding region

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [280-426]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNNWQDLTQN LPKQQAKTGE QRFENHMSNA LPQTTINKTN DKLYISNLQS RKSETVEKQS  60
   61 EDIFTELADI LHSNQIPRNH ILSASLLIRD MSNFGKINKI YNEFLDLSKY GPLPPSRACV 120
  121 GSKCLPEDCH VQLSVVVDVK NTGKEKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	102.751666
Match:	1qd9A_
Description:	Purine regulatory protein YabJ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribonuclease activity	2.55513289511254	bayes_pls_golite062009
nuclease activity	1.95684086528131	bayes_pls_golite062009
endonuclease activity	1.93161199243014	bayes_pls_golite062009
binding	1.28584712198396	bayes_pls_golite062009
endoribonuclease activity	1.18839679198466	bayes_pls_golite062009
catalytic activity	1.00848565859536	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.659253495197665	bayes_pls_golite062009
hydrolase activity	0.213547115506972	bayes_pls_golite062009
protein binding	0.126122948490201	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [427-587]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKNKGGLHVQ GRSYWAPCNI GPYSQSTWLN DDANQVSFIS GQIGLVPQSM EILGTPLTDQ  60
   61 IVLALQHFDT LCETIGAQEK LLMTCYISDE SVLDSVIKTW AFYCSNMNHR SDLWMDKSDD 120
  121 VEKCLVLVKI SELPRGAVAE FGGVTCKRLI VDDNDSDKKE R

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.796	N/A	N/A	d.129.4	Cell-division protein ZipA, C-terminal domain
View	Download	0.757	N/A	N/A	c.52.2	tRNA splicing endonuclease, C-terminal domain
View	Download	0.748	N/A	N/A	c.37.1	P-loop containing nucleoside triphosphate hydrolases
View	Download	0.620	N/A	N/A	c.13.2	Anti-sigma factor antagonist SpoIIaa
View	Download	0.577	N/A	N/A	c.37.1	P-loop containing nucleoside triphosphate hydrolases

Predicted Domain #5

Region A:
Residues: [588-685]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EENDDVSTVF QKLNLNIEGF HNTTVSAFGY NRNFITGFVD SREELELILE KTPKSAQITL  60
   61 YYNPKEIITF HHHIGYYPVE KLFDYRGKEH RFGLHIRS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.748	0.909	cytoplasm	c.37.1	P-loop containing nucleoside triphosphate hydrolases
View	Download	0.796	0.909	cytoplasm	d.129.4	Cell-division protein ZipA, C-terminal domain
View	Download	0.757	0.909	cytoplasm	c.52.2	tRNA splicing endonuclease, C-terminal domain
View	Download	0.620	0.909	cytoplasm	c.13.2	Anti-sigma factor antagonist SpoIIaa
View	Download	0.554	0.909	cytoplasm	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.518	0.909	cytoplasm	c.30.1	PreATP-grasp domain
View	Download	0.512	0.909	cytoplasm	c.13.2	Anti-sigma factor antagonist SpoIIaa
View	Download	0.487	0.909	cytoplasm	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.475	0.909	cytoplasm	c.115.1	Hypothetical protein MTH777 (MT0777)
View	Download	0.461	0.909	cytoplasm	a.1.1	Globin-like
View	Download	0.449	0.909	cytoplasm	d.58.19	Bacterial exopeptidase dimerisation domain
View	Download	0.431	0.909	cytoplasm	c.23.5	Flavoproteins
View	Download	0.427	0.909	cytoplasm	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.422	0.909	cytoplasm	d.79.2	Tubulin/Dihydroxyacetone kinase C-terminal domain
View	Download	0.419	0.909	cytoplasm	c.58.1	Aminoacid dehydrogenase-like, N-terminal domain
View	Download	0.418	0.909	cytoplasm	d.68.4	YhbY-like
View	Download	0.406	0.909	cytoplasm	d.16.1	FAD-linked reductases, C-terminal domain
View	Download	0.404	0.909	cytoplasm	c.53.1	Resolvase-like
View	Download	0.400	0.909	cytoplasm	d.109.1	Actin depolymerizing proteins
View	Download	0.394	0.909	cytoplasm	c.48.1	TK C-terminal domain-like
View	Download	0.392	0.909	cytoplasm	c.58.1	Aminoacid dehydrogenase-like, N-terminal domain
View	Download	0.384	0.909	cytoplasm	c.46.1	Rhodanese/Cell cycle control phosphatase
View	Download	0.383	0.909	cytoplasm	c.24.1	Methylglyoxal synthase-like
View	Download	0.371	0.909	cytoplasm	c.9.1	Barstar (barnase inhibitor)
View	Download	0.370	0.909	cytoplasm	c.9.1	Barstar (barnase inhibitor)
View	Download	0.368	0.909	cytoplasm	d.79.2	Tubulin/Dihydroxyacetone kinase C-terminal domain
View	Download	0.351	0.909	cytoplasm	c.32.1	Tubulin/Dihydroxyacetone kinase nucleotide-binding domain
View	Download	0.349	0.909	cytoplasm	c.102.1	Cell-division inhibitor MinC, N-terminal domain
View	Download	0.349	0.909	cytoplasm	c.44.2	Enzyme IIB-cellobiose
View	Download	0.347	0.909	cytoplasm	d.58.19	Bacterial exopeptidase dimerisation domain
View	Download	0.343	0.909	cytoplasm	c.36.1	Thiamin diphosphate-binding fold (THDP-binding)
View	Download	0.339	0.909	cytoplasm	d.52.3	Prokaryotic type KH domain (KH-domain type II)
View	Download	0.339	0.909	cytoplasm	d.109.1	Actin depolymerizing proteins
View	Download	0.321	0.909	cytoplasm	d.129.4	Cell-division protein ZipA, C-terminal domain
View	Download	0.318	0.909	cytoplasm	d.79.2	Tubulin/Dihydroxyacetone kinase C-terminal domain
View	Download	0.313	0.909	cytoplasm	c.13.2	Anti-sigma factor antagonist SpoIIaa
View	Download	0.312	0.909	cytoplasm	d.82.1	Copper amine oxidase, domain N
View	Download	0.309	0.909	cytoplasm	d.110.1	Profilin (actin-binding protein)
View	Download	0.307	0.909	cytoplasm	b.11.1	gamma-Crystallin-like
View	Download	0.307	0.909	cytoplasm	c.52.1	Restriction endonuclease-like
View	Download	0.306	0.909	cytoplasm	c.84.1	Phosphoglucomutase, first 3 domains
View	Download	0.306	0.909	cytoplasm	c.44.2	Enzyme IIB-cellobiose
View	Download	0.299	0.909	cytoplasm	d.16.1	FAD-linked reductases, C-terminal domain
View	Download	0.296	0.909	cytoplasm	c.23.14	Nucleoside 2-deoxyribosyltransferase
View	Download	0.294	0.909	cytoplasm	c.16.1	Lumazine synthase
View	Download	0.291	0.909	cytoplasm	d.58.11	EF-G/eEF-2 domains III and V
View	Download	0.280	0.909	cytoplasm	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.279	0.909	cytoplasm	d.79.2	Tubulin/Dihydroxyacetone kinase C-terminal domain
View	Download	0.277	0.909	cytoplasm	d.68.3	SirA-like
View	Download	0.277	0.909	cytoplasm	d.169.1	C-type lectin-like
View	Download	0.276	0.909	cytoplasm	a.40.1	Calponin-homology domain, CH-domain
View	Download	0.271	0.909	cytoplasm	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.268	0.909	cytoplasm	d.45.1	ClpS-like
View	Download	0.265	0.909	cytoplasm	d.79.4	Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain
View	Download	0.264	0.909	cytoplasm	c.32.1	Tubulin/Dihydroxyacetone kinase nucleotide-binding domain
View	Download	0.263	0.909	cytoplasm	d.82.1	Copper amine oxidase, domain N
View	Download	0.260	0.909	cytoplasm	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.258	0.909	cytoplasm	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.255	0.909	cytoplasm	c.23.12	Formate/glycerate dehydrogenase catalytic domain-like
View	Download	0.254	0.909	cytoplasm	c.49.1	Pyruvate kinase, C-terminal domain
View	Download	0.252	0.909	cytoplasm	d.58.19	Bacterial exopeptidase dimerisation domain
View	Download	0.234	0.909	cytoplasm	d.82.1	Copper amine oxidase, domain N
View	Download	0.232	0.909	cytoplasm	c.3.1	FAD/NAD(P)-binding domain
View	Download	0.231	0.909	cytoplasm	a.4.2	Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View	Download	0.231	0.909	cytoplasm	c.38.1	PTS IIb component
View	Download	0.230	0.909	cytoplasm	d.44.1	Fe,Mn superoxide dismutase (SOD), C-terminal domain
View	Download	0.227	0.909	cytoplasm	d.82.2	Frataxin-like
View	Download	0.225	0.909	cytoplasm	d.94.1	HPr-like
View	Download	0.220	0.909	cytoplasm	c.23.1	CheY-like
View	Download	0.219	0.909	cytoplasm	d.79.1	YjgF-like
View	Download	0.218	0.909	cytoplasm	c.30.1	PreATP-grasp domain
View	Download	0.218	0.909	cytoplasm	a.77.1	DEATH domain
View	Download	0.217	0.909	cytoplasm	d.52.3	Prokaryotic type KH domain (KH-domain type II)
View	Download	0.213	0.909	cytoplasm	a.28.2	Colicin E immunity proteins
View	Download	0.205	0.909	cytoplasm	c.26.2	Adenine nucleotide alpha hydrolases-like
View	Download	0.202	0.909	cytoplasm	c.61.1	PRTase-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: