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View Structure Prediction Details

Protein: HBS1
Organism: Saccharomyces cerevisiae
Length: 611 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HBS1.

Description E-value Query
Range
Subject
Range
EF1A1_CANAL - Elongation factor 1-alpha 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TEF1 PE=3 SV=1
EF1A_CANAL - Elongation factor 1-alpha OS=Candida albicans GN=TEF1 PE=1 SV=1
gi|238878741, gi... - gi|238883715|gb|EEQ47353.1| elongation factor 1-alpha [Candida albicans WO-1], gi|238878741|gb|EEQ42...
0.0 [163..611] [3..441]
EF1A_ABSGL - Elongation factor 1-alpha OS=Absidia glauca GN=TEF-1 PE=3 SV=1
0.0 [163..611] [3..441]
gi|13278382 - gi|13278382|gb|AAH04005.1| Eukaryotic translation elongation factor 1 alpha 1 [Mus musculus]
0.0 [163..611] [3..443]
gi|169409549 - gi|169409549|gb|ACA57895.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Calliceb...
EF1A1_PANTR - Elongation factor 1-alpha 1 OS=Pan troglodytes GN=EEF1A1 PE=2 SV=1
gi|163781003 - gi|163781003|gb|ABY40784.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Papio an...
gi|67970565 - gi|67970565|dbj|BAE01625.1| unnamed protein product [Macaca fascicularis]
EF1A1_PONAB - Elongation factor 1-alpha 1 OS=Pongo abelii GN=EEF1A1 PE=2 SV=2
EEF1A1 - eukaryotic translation elongation factor 1 alpha 1
gi|60819043, gi|... - gi|61363070|gb|AAX42329.1| eukaryotic translation elongation factor 1 alpha 1 [synthetic construct],...
gi|73973292 - gi|73973292|ref|XP_532203.2| PREDICTED: similar to eukaryotic translation elongation factor 1 alpha ...
gi|229368700 - gi|229368700|gb|ACQ62985.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Dasypus ...
tr|F6UME7|F6UME7... - Elongation factor 1-alpha OS=Equus caballus OX=9796 GN=EEF1A1 PE=3 SV=1
gi|56342332|dbj|... - eukaryotic translation elongation factor 1 alpha 1 [Pan troglodytes]
EF1A1_BOVIN - Elongation factor 1-alpha 1 OS=Bos taurus GN=EEF1A1 PE=1 SV=1
EF1A1_PONPY - Elongation factor 1-alpha 1 - Pongo pygmaeus (Orangutan)
EF1A1_RABIT - Elongation factor 1-alpha 1 OS=Oryctolagus cuniculus GN=EEF1A1 PE=1 SV=1
gi|109071708, gi... - gi|109071710|ref|XP_001112777.1| PREDICTED: similar to eukaryotic translation elongation factor 1 al...
EF1A1_FELCA - Elongation factor 1-alpha 1 OS=Felis catus GN=EEF1A1 PE=2 SV=1
gi|223019597, gi... - gi|223019599|emb|CAX36487.1| eukaryotic translation elongation factor 1 alpha 1 [Sus scrofa], gi|223...
ENSCJAT00000019570 - null
0.0 [163..611] [3..443]
gi|15805031, gi|... - gi|15805031|ref|NP_284925.1| eukaryotic translation elongation factor 1 alpha 2 [Rattus norvegicus],...
0.0 [163..611] [3..443]
EF1A3_RHIRA, EF1... - Elongation factor 1-alpha OS=Rhizomucor racemosus GN=TEF-3 PE=3 SV=1, (P14865) Elongation factor 1-a...
EF1A3_MUCCL - Elongation factor 1-alpha OS=Mucor circinelloides f. lusitanicus GN=TEF-3 PE=3 SV=1
0.0 [163..611] [3..440]
EF1A_CHICK - Elongation factor 1-alpha 1 OS=Gallus gallus GN=EEF1A PE=2 SV=1
0.0 [163..611] [3..443]
EF1A0_XENLA - Elongation factor 1-alpha, somatic form OS=Xenopus laevis GN=eef1as PE=2 SV=1
0.0 [163..611] [3..443]
EF1A_BLAAD - Elongation factor 1-alpha OS=Blastobotrys adeninivorans GN=TEF PE=3 SV=1
EF1A_ARXAD - Elongation factor 1-alpha OS=Arxula adeninivorans GN=TEF PE=3 SV=1
0.0 [163..611] [3..441]

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Predicted Domain #1
Region A:
Residues: [1-152]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYSDYSDGA DDMPDFHDEG EFDDYLNDDE YDLMNEVFPT LKAQLQDYQG WDNLSLKLAL  60
   61 FDNNFDLEST LAELKKTLKK KKTPKKPIAA ANGSANVTQK LANISISQQR PNDRLPDWLD 120
  121 EEESEGERNG EEANDEKTVQ RYYKTTVPTK PK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [153-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPHDISAFVK SALPHLSFVV LGHVDAGKST LMGRLLYDLN IVNQSQLRKL QRESETMGKS  60
   61 SFKFAWIMDQ TNEERERGVT VSICTSHFST HRANFTIVDA PGHRDFVPNA IMGISQADMA 120
  121 ILCVDCSTNA FESGFDLDGQ TKEHMLLASS LGIHNLIIAM NKMDNVDWSQ QRFEEIKSKL 180
  181 LPYLVDIGFF EDNINWVPIS GFSGEGVYKI EYTDEVRQWY NGPNLMSTLE NAAFKISKEN 240
  241 E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1580.0
Match: 1jnyA_
Description: Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation elongation factor activity 8.90683166637832 bayes_pls_golite062009
translation factor activity, nucleic acid binding 4.8378725567094 bayes_pls_golite062009
translation regulator activity 4.79814772079421 bayes_pls_golite062009
actin binding 2.84620358490972 bayes_pls_golite062009
cytoskeletal protein binding 2.66896300219871 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
actin filament binding 2.1683792904715 bayes_pls_golite062009
motor activity 1.64238426331767 bayes_pls_golite062009
nucleic acid binding 1.49633029954726 bayes_pls_golite062009
purine ribonucleotide binding 1.2935968641033 bayes_pls_golite062009
ribonucleotide binding 1.2935353851804 bayes_pls_golite062009
purine nucleotide binding 1.29138695385133 bayes_pls_golite062009
nucleotide binding 1.28669586915546 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription regulator activity 0.989226939888218 bayes_pls_golite062009
ATP binding 0.98146619596929 bayes_pls_golite062009
DNA binding 0.967303417236485 bayes_pls_golite062009
adenyl ribonucleotide binding 0.949788783884952 bayes_pls_golite062009
adenyl nucleotide binding 0.931486373329219 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
microtubule motor activity 0.87576779858246 bayes_pls_golite062009
structural constituent of ribosome 0.860102064846772 bayes_pls_golite062009
microfilament motor activity 0.842051467704019 bayes_pls_golite062009
RNA binding 0.715902454627085 bayes_pls_golite062009
kinase activity 0.691112783105676 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.499834566483656 bayes_pls_golite062009
0.3172470686972 bayes_pls_golite062009
ribonuclease activity 0.222424272323909 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
pyrophosphatase activity 0.133017653323467 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
structural molecule activity 0.11239762372728 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
transcription factor activity 0.0434163635422169 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0430764033739892 bayes_pls_golite062009
protein kinase activity 0.0364322017534667 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [394-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GINKDDPFLF SVLEIIPSKK TSNDLALVSG KLESGSIQPG ESLTIYPSEQ SCIVDKIQVG  60
   61 SQQGQSTNHE ETDVAIKGDF VTLKLRKAYP EDIQNGDLAA SVDYSSI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1580.0
Match: 1jnyA_
Description: Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [501-611]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSAQCFVLEL TTFDMNRPLL PGTPFILFIG VKEQPARIKR LISFIDKGNT ASKKKIRHLG  60
   61 SKQRAFVEIE LIEVKRWIPL LTAHENDRLG RVVLRKDGRT IAAGKISEIT Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1580.0
Match: 1jnyA_
Description: Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle