YRC Public Data Repository - Protein Structure Prediction

Protein:	CPR7
Organism:	Saccharomyces cerevisiae
Length:	393 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPR7.

Description	E-value	Query Range	Subject Range
PPID_BOVIN - Peptidyl-prolyl cis-trans isomerase D OS=Bos taurus GN=PPID PE=1 SV=6	0.0	[3..393]	[14..370]
PPID_MOUSE - Peptidyl-prolyl cis-trans isomerase D OS=Mus musculus GN=Ppid PE=1 SV=3	0.0	[2..393]	[13..370]
gi\|123996147, gi... - gi\|123996147\|gb\|ABM85675.1\| peptidylprolyl isomerase D (cyclophilin D) [synthetic construct], gi\|123... PPID - peptidylprolyl isomerase D	0.0	[3..393]	[14..370]
CPR7 - Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide ... gi\|151945102 - gi\|151945102\|gb\|EDN63353.1\| PPIase [Saccharomyces cerevisiae YJM789] CYP7_YEAST - Peptidyl-prolyl cis-trans isomerase CYP7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...	0.0	[1..393]	[1..393]
CYP40_ARATH - Peptidyl-prolyl cis-trans isomerase CYP40 OS=Arabidopsis thaliana GN=CYP40 PE=2 SV=1	0.0	[2..392]	[1..360]
PPID_NEUCR - 41 kDa peptidyl-prolyl cis-trans isomerase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CB... PPID_NEUCR - 41 kDa peptidyl-prolyl cis-trans isomerase OS=Neurospora crassa GN=cyp-41 PE=2 SV=1	0.0	[3..393]	[10..375]
PPID_SCHPO - 40 kDa peptidyl-prolyl cis-trans isomerase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN... wis2 - cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2	4.0E-92	[8..392]	[6..355]

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Predicted Domain #1

Region A:
Residues: [1-209]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIQDPLVYLD ISIDKKPIGR IVCKLFREKA PKTTENFYKL CAGDVKSPLK DQQYLSYKGN  60
   61 GFHRVVKNFM IQAGDIVFGT QKDSSSSSVG KGGCSIYADK EEVKTDDESF CYGNFEDENL 120
  121 GEFVEPFTLG MANLGSPNTN NSQFFITTYA APHLNGKHSI FGQVVHGKSV VRTIENCRVD 180
  181 SDGVPESDVR ISDCGVWEKT MGVPLYNAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	541.228787
Match:	1ihgA_
Description:	Cyclophilin 40; Cyclophilin 40 isomerase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	4.3775483906311	bayes_pls_golite062009
histone deacetylase activity	4.29026678196473	bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity	3.73853378771688	bayes_pls_golite062009
cis-trans isomerase activity	3.66963215732405	bayes_pls_golite062009
deacetylase activity	3.49940864924766	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3.01511519120932	bayes_pls_golite062009
RNA binding	2.94609837984526	bayes_pls_golite062009
signal sequence binding	2.68460419248567	bayes_pls_golite062009
isomerase activity	1.96529188741504	bayes_pls_golite062009
binding	1.65866393331484	bayes_pls_golite062009
mRNA binding	1.45537055700871	bayes_pls_golite062009
unfolded protein binding	1.38124355054041	bayes_pls_golite062009
transcription regulator activity	1.26149030245805	bayes_pls_golite062009
peroxisome targeting sequence binding	1.01220052237687	bayes_pls_golite062009
DNA binding	0.9531600253493	bayes_pls_golite062009
nucleic acid binding	0.939772862764466	bayes_pls_golite062009
catalytic activity	0.748655649755714	bayes_pls_golite062009
molecular transducer activity	0.679771252160931	bayes_pls_golite062009
signal transducer activity	0.679771252160931	bayes_pls_golite062009
hydrolase activity	0.493806105600863	bayes_pls_golite062009
receptor binding	0.420639979573538	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.408539130322443	bayes_pls_golite062009
transcription factor activity	0.374364600772076	bayes_pls_golite062009
drug binding	0.36339132904137	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.322244688184474	bayes_pls_golite062009
small conjugating protein ligase activity	0.286133802341887	bayes_pls_golite062009
histone binding	0.268719695649015	bayes_pls_golite062009
protein binding	0.230077752280113	bayes_pls_golite062009
N-acetyltransferase activity	0.105969834846946	bayes_pls_golite062009
peptide binding	0.0124550142154398	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [210-305]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDQIGGDVYE EYPDDDTHFG DDDFGKALEA ANIIKESGTL LFKKKDYSNA FFKYRKSLNY  60
   61 INEYMPEPDV DKERNIQFIN LKMKIYLNLS LVLFNL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	541.228787
Match:	1ihgA_
Description:	Cyclophilin 40; Cyclophilin 40 isomerase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [306-393]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERYDDAIMYA TYLLEMDNVP NRDQAKAYYR RGNSYLKKKR LDEALQDYIF CKEKNPDDEV  60
   61 IEQRIEYVNR LIEENKEKTR KNISKFFS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	541.228787
Match:	1ihgA_
Description:	Cyclophilin 40; Cyclophilin 40 isomerase domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: