| Protein: | GCN5 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 439 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCN5.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..439] | [1..439] |
|
|
0.0 | [9..428] | [64..504] |
|
|
0.0 | [1..429] | [74..558] |
|
|
0.0 | [29..430] | [335..754] |
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|
0.0 | [26..430] | [48..470] |
|
|
0.0 | [26..430] | [409..831] |
|
Region A: Residues: [1-70] |
1 11 21 31 41 51
| | | | | |
1 MVTKHQIEED HLDGATTDPE VKRVKLENNV EEIQPEQAET NKQEGTDKEN KGKFEKETER 60
61 IGGSEVVTDV
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.371 | a.39.1 | EF-hand |
| View | Download | 0.433 | a.65.1 | Annexin |
| View | Download | 0.556 | a.139.1 | Type I dockerin domain |
| View | Download | 0.344 | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.530 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.325 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.307 | d.58.36 | Sulfite reductase, domains 1 and 3 |
| View | Download | 0.284 | a.20.1 | PGBD-like |
| View | Download | 0.282 | a.108.1 | Ribosomal protein L7/12, oligomerisation (N-terminal) domain |
| View | Download | 0.280 | a.77.1 | DEATH domain |
| View | Download | 0.269 | a.64.1 | Saposin |
| View | Download | 0.262 | a.3.1 | Cytochrome c |
| View | Download | 0.261 | a.39.1 | EF-hand |
| View | Download | 0.260 | a.4.9 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
| View | Download | 0.249 | a.4.1 | Homeodomain-like |
| View | Download | 0.231 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.226 | a.4.1 | Homeodomain-like |
| View | Download | 0.219 | b.36.1 | PDZ domain-like |
| View | Download | 0.216 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.204 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.203 | a.4.6 | C-terminal effector domain of the bipartite response regulators |
|
Region A: Residues: [71-162] |
1 11 21 31 41 51
| | | | | |
1 EKGIVKFEFD GVEYTFKERP SVVEENEGKI EFRVVNNDNT KENMMVLTGL KNIFQKQLPK 60
61 MPKEYIARLV YDRSHLSMAV IRKPLTVVGG IT
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|
Region B: Residues: [176-191] |
1 11 21 31 41 51
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1 FCAISSTEQV RGYGAH
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| Detection Method: | |
| Confidence: | 993.045757 |
| Match: | 1yghA_ |
| Description: | Catalytic domain of GCN5 histone acetyltransferase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| N-acetyltransferase activity | 10.330867741687 | bayes_pls_golite062009 |
| histone acetyltransferase activity | 10.2385402730839 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 10.2385402730839 | bayes_pls_golite062009 |
| N-acyltransferase activity | 10.2097972775096 | bayes_pls_golite062009 |
| acetyltransferase activity | 9.5414870492393 | bayes_pls_golite062009 |
| acyltransferase activity | 8.84144467104026 | bayes_pls_golite062009 |
| transferase activity, transferring acyl groups other than amino-acyl groups | 8.80032457938662 | bayes_pls_golite062009 |
| transferase activity, transferring acyl groups | 8.58458341779614 | bayes_pls_golite062009 |
| 7.30820970670781 | bayes_pls_golite062009 | |
| H3 histone acetyltransferase activity | 6.1481916320934 | bayes_pls_golite062009 |
| 3.86052919290021 | bayes_pls_golite062009 | |
| general RNA polymerase II transcription factor activity | 3.07485575332112 | bayes_pls_golite062009 |
| transferase activity | 2.87429355361226 | bayes_pls_golite062009 |
| transcription regulator activity | 2.24760844790231 | bayes_pls_golite062009 |
| nucleic acid binding | 2.13750665291344 | bayes_pls_golite062009 |
| catalytic activity | 1.97933499002461 | bayes_pls_golite062009 |
| binding | 1.22537494136129 | bayes_pls_golite062009 |
| transcription coactivator activity | 1.2180007740195 | bayes_pls_golite062009 |
| transcription factor binding | 1.13174003342838 | bayes_pls_golite062009 |
| transcription activator activity | 0.891911076312861 | bayes_pls_golite062009 |
| glycylpeptide N-tetradecanoyltransferase activity | 0.774009286200155 | bayes_pls_golite062009 |
| myristoyltransferase activity | 0.774009286200155 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.605899196605446 | bayes_pls_golite062009 |
| histone binding | 0.582104626133107 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.31196049232138 | bayes_pls_golite062009 |
| protein binding | 0.075825416385311 | bayes_pls_golite062009 |
| RNA polymerase II transcription mediator activity | 0.0178952175491798 | bayes_pls_golite062009 |
|
Region A: Residues: [163-175] |
1 11 21 31 41 51
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1 YRPFDKREFA EIV
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Region B: Residues: [192-234] |
1 11 21 31 41 51
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1 LMNHLKDYVR NTSNIKYFLT YADNYAIGYF KKQGFTKEIT LDK
|
| Detection Method: | |
| Confidence: | 993.045757 |
| Match: | 1yghA_ |
| Description: | Catalytic domain of GCN5 histone acetyltransferase |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [235-319] |
1 11 21 31 41 51
| | | | | |
1 SIWMGYIKDY EGGTLMQCSM LPRIRYLDAG KILLLQEAAL RRKIRTISKS HIVRPGLEQF 60
61 KDLNNIKPID PMTIPGLKEA GWTPE
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.431 | d.14.1 | Ribosomal protein S5 domain 2-like |
| View | Download | 0.449 | a.22.1 | Histone-fold |
| View | Download | 0.446 | a.2.11 | Fe,Mn superoxide dismutase (SOD), N-terminal domain |
| View | Download | 0.525 | a.59.1 | PAH2 domain |
| View | Download | 0.571 | a.13.1 | alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 |
| View | Download | 0.431 | a.23.1 | HSC20 (HSCB), C-terminal oligomerisation domain |
| View | Download | 0.430 | f.17.1 | F1F0 ATP synthase subunit C |
| View | Download | 0.427 | a.7.1 | Spectrin repeat |
| View | Download | 0.403 | a.2.6 | Effector domain of the protein kinase pkn/prk1 |
| View | Download | 0.396 | a.2.8 | Eukaryotic DNA topoisomerase I, dispensable insert domain |
| View | Download | 0.376 | d.15.1 | Ubiquitin-like |
| View | Download | 0.370 | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.367 | d.15.1 | Ubiquitin-like |
| View | Download | 0.359 | i.1.1 | Ribosome and ribosomal fragments |
| View | Download | 0.344 | a.22.1 | Histone-fold |
| View | Download | 0.331 | b.36.1 | PDZ domain-like |
| View | Download | 0.330 | a.4.1 | Homeodomain-like |
| View | Download | 0.324 | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.318 | d.110.4 | SNARE-like |
| View | Download | 0.316 | a.4.13 | Sigma3 and sigma4 domains of RNA polymerase sigma factors |
| View | Download | 0.315 | a.47.2 | t-snare proteins |
| View | Download | 0.315 | a.2.1 | GreA transcript cleavage protein, N-terminal domain |
| View | Download | 0.311 | a.4.1 | Homeodomain-like |
| View | Download | 0.306 | a.2.11 | Fe,Mn superoxide dismutase (SOD), N-terminal domain |
| View | Download | 0.291 | b.1.1 | Immunoglobulin |
| View | Download | 0.290 | a.7.7 | BAG domain |
| View | Download | 0.289 | d.52.1 | Alpha-lytic protease prodomain |
| View | Download | 0.270 | d.15.11 | Doublecortin (DC) |
| View | Download | 0.269 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.264 | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.247 | d.58.14 | Ribosomal protein S6 |
| View | Download | 0.238 | a.7.2 | Enzyme IIa from lactose specific PTS, IIa-lac |
| View | Download | 0.237 | a.163.1 | Crustacean CHH/MIH/GIH neurohormone |
| View | Download | 0.230 | d.42.1 | POZ domain |
| View | Download | 0.223 | d.14.1 | Ribosomal protein S5 domain 2-like |
| View | Download | 0.217 | c.47.1 | Thioredoxin-like |
| View | Download | 0.214 | d.88.1 | SRF-like |
| View | Download | 0.214 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.211 | d.13.1 | HIT-like |
| View | Download | 0.210 | a.118.8 | TPR-like |
| View | Download | 0.209 | a.90.1 | Transcription factor STAT-4 N-domain |
| View | Download | 0.208 | d.226.1 | GIY-YIG endonuclease |
| View | Download | 0.201 | a.24.17 | Group V grass pollen allergen |
| Term | Confidence | Notes |
| histone acetyltransferase activity | 9.91927576220387 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 9.91927576220387 | bayes_pls_golite062009 |
| N-acetyltransferase activity | 7.57346092874507 | bayes_pls_golite062009 |
| N-acyltransferase activity | 7.12398761720889 | bayes_pls_golite062009 |
| acetyltransferase activity | 6.51488433263281 | bayes_pls_golite062009 |
| acyltransferase activity | 5.44980261163837 | bayes_pls_golite062009 |
| transferase activity, transferring acyl groups other than amino-acyl groups | 5.38368530556466 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 5.26899007107713 | bayes_pls_golite062009 |
| transferase activity, transferring acyl groups | 5.06705016462047 | bayes_pls_golite062009 |
| 4.94702795409425 | bayes_pls_golite062009 | |
| transcription regulator activity | 3.81944587687526 | bayes_pls_golite062009 |
| DNA binding | 3.34863990009219 | bayes_pls_golite062009 |
| nucleic acid binding | 3.25178464591722 | bayes_pls_golite062009 |
| binding | 3.24233563871512 | bayes_pls_golite062009 |
| histone binding | 2.93206976627622 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 2.58609800997327 | bayes_pls_golite062009 |
| transcription coactivator activity | 2.37993162280856 | bayes_pls_golite062009 |
| transcription factor binding | 2.33866683789609 | bayes_pls_golite062009 |
| transcription activator activity | 1.99519727421308 | bayes_pls_golite062009 |
| MyoD binding | 1.89625280750577 | bayes_pls_golite062009 |
| MRF binding | 1.89625280750577 | bayes_pls_golite062009 |
| chromatin binding | 1.85568770971367 | bayes_pls_golite062009 |
| protein binding | 1.82955314054861 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.82747962293997 | bayes_pls_golite062009 |
| protein kinase activity | 1.63512839295568 | bayes_pls_golite062009 |
| transcription cofactor activity | 1.60584871002187 | bayes_pls_golite062009 |
| transcription factor activity | 1.30026489619787 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 1.15145628425168 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.08961199627679 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.07760436003896 | bayes_pls_golite062009 |
| transcription initiation factor activity | 0.96034823197127 | bayes_pls_golite062009 |
| kinase activity | 0.890638513095454 | bayes_pls_golite062009 |
| peroxisome proliferator activated receptor binding | 0.547697825358481 | bayes_pls_golite062009 |
| structural molecule activity | 0.398844600914114 | bayes_pls_golite062009 |
| transferase activity | 0.321534577277088 | bayes_pls_golite062009 |
| transcription repressor activity | 0.0167144924052265 | bayes_pls_golite062009 |
|
Region A: Residues: [320-439] |
1 11 21 31 41 51
| | | | | |
1 MDALAQRPKR GPHDAAIQNI LTELQNHAAA WPFLQPVNKE EVPDYYDFIK EPMDLSTMEI 60
61 KLESNKYQKM EDFIYDARLV FNNCRMYNGE NTSYYKYANR LEKFFNNKVK EIPEYSHLID 120
121
|
| Detection Method: | |
| Confidence: | 655.66807 |
| Match: | 1e6iA_ |
| Description: | GCN5 |
Matching Structure (courtesy of the PDB): |
|
