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View Structure Prediction Details

Protein: RSP5
Organism: Saccharomyces cerevisiae
Length: 809 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RSP5.

Description E-value Query
Range		 Subject
Range
RSP5_YEAST - E3 ubiquitin-protein ligase RSP5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RSP5 PE...
RSP5 - E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes, including M...
 0.0 [1..809] [1..809]
PUB1_SCHPO - E3 ubiquitin-protein ligase pub1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pub1 PE=1...
pub1 - ubiquitin-protein ligase E3
 0.0 [5..809] [10..767]
WWP2_MOUSE - NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Mus musculus GN=Wwp2 PE=1 SV=1
 0.0 [2..809] [17..870]
gi|123980542, gi... - gi|123995361|gb|ABM85282.1| WW domain containing E3 ubiquitin protein ligase 2 [synthetic construct]...
WWP2 - WW domain containing E3 ubiquitin protein ligase 2
 0.0 [2..809] [17..870]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [5..809] [10..766]

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Predicted Domain #1
Region A:
Residues: [1-199] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSSISVKLV AAESLYKRDV FRSPDPFAVL TIDGYQTKST SAAKKTLNPY WNETFKFDDI  60
   61 NENSILTIQV FDQKKFKKKD QGFLGVVNVR VGDVLGHLDE DTATSSGRPR EETITRDLKK 120
  121 SNDGMAVSGR LIVVLSKLPS SSPHSQAPSG HTASSSTNTS STTRTNGHST SSTRNHSTSH 180
  181 PSRGTAQAVE STLQSGTTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.69897
Match: 1dqvA_
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [200-314] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATNTATTSHR STNSTSSATR QYSSFEDQYG RLPPGWERRT DNFGRTYYVD HNTRTTTWKR  60
   61 PTLDQTEAER GNQLNANTEL ERRQHRGRTL PGGSSDNSSV TVQVGGGSNI PPVNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.67837
Match: 1f8aB_
Description: Mitotic rotamase PIN1; Mitotic rotamase PIN1, domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.19063870734022 bayes_pls_golite062009
small conjugating protein ligase activity 6.90783262781184 bayes_pls_golite062009
acid-amino acid ligase activity 6.09904629433884 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 5.1950291192201 bayes_pls_golite062009
ligase activity 4.32965319288714 bayes_pls_golite062009
transcription activator activity 3.61296179666474 bayes_pls_golite062009
transcription regulator activity 3.2682543222543 bayes_pls_golite062009
binding 2.62219069341981 bayes_pls_golite062009
protein binding 2.51948432647454 bayes_pls_golite062009
transcription factor binding 2.18630749239417 bayes_pls_golite062009
transcription cofactor activity 2.07432061489599 bayes_pls_golite062009
transcription coactivator activity 2.02433252968502 bayes_pls_golite062009
histone methyltransferase activity 1.90194027965368 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein methyltransferase activity 1.121001087082 bayes_pls_golite062009
catalytic activity 0.210712504691113 bayes_pls_golite062009
transcription repressor activity 0.18603158355229 bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific) 0.173723075520888 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [315-372] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAAAAFAATG GTTSGLGELP SGWEQRFTPE GRAYFVDHNT RTTTWVDPRR QQYIRTYG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.264245
Match: 1i5hW_
Description: Ubiquitin ligase NEDD4 WWIII domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.19063870734022 bayes_pls_golite062009
small conjugating protein ligase activity 6.90783262781184 bayes_pls_golite062009
acid-amino acid ligase activity 6.09904629433884 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 5.1950291192201 bayes_pls_golite062009
ligase activity 4.32965319288714 bayes_pls_golite062009
transcription activator activity 3.61296179666474 bayes_pls_golite062009
transcription regulator activity 3.2682543222543 bayes_pls_golite062009
binding 2.62219069341981 bayes_pls_golite062009
protein binding 2.51948432647454 bayes_pls_golite062009
transcription factor binding 2.18630749239417 bayes_pls_golite062009
transcription cofactor activity 2.07432061489599 bayes_pls_golite062009
transcription coactivator activity 2.02433252968502 bayes_pls_golite062009
histone methyltransferase activity 1.90194027965368 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein methyltransferase activity 1.121001087082 bayes_pls_golite062009
catalytic activity 0.210712504691113 bayes_pls_golite062009
transcription repressor activity 0.18603158355229 bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific) 0.173723075520888 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [373-450] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTNTTIQQQP VSQLGPLPSG WEMRLTNTAR VYFVDHNTKT TTWDDPRLPS SLDQNVPQYK  60
   61 RDFRRKVIYF RSQPALRI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.59
Match: 1i5hW
Description: Ubiquitin ligase NEDD4 WWIII domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 11.7414753295465 bayes_pls_golite062009
small conjugating protein ligase activity 11.4871643691645 bayes_pls_golite062009
acid-amino acid ligase activity 10.4323719338452 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 9.13168684685485 bayes_pls_golite062009
ligase activity 7.74494807432593 bayes_pls_golite062009
sodium channel inhibitor activity 6.01425793895251 bayes_pls_golite062009
phosphothreonine binding 5.90497053948475 bayes_pls_golite062009
phosphoserine binding 5.90497053948475 bayes_pls_golite062009
ion channel inhibitor activity 2.86572445544473 bayes_pls_golite062009
channel inhibitor activity 2.86572445544473 bayes_pls_golite062009
binding 2.51893471705946 bayes_pls_golite062009
protein binding 2.44418607577971 bayes_pls_golite062009
transcription regulator activity 2.32249912875549 bayes_pls_golite062009
nucleic acid binding 2.12515000812201 bayes_pls_golite062009
DNA binding 1.96906809911381 bayes_pls_golite062009
SMAD binding 1.72092268696303 bayes_pls_golite062009
1.3844044305632 bayes_pls_golite062009
channel regulator activity 1.37005888814694 bayes_pls_golite062009
transcription activator activity 1.36023462068212 bayes_pls_golite062009
sodium channel regulator activity 1.19047973745862 bayes_pls_golite062009
receptor binding 1.15852292149378 bayes_pls_golite062009
catalytic activity 1.15152367676155 bayes_pls_golite062009
R-SMAD binding 1.09824752083864 bayes_pls_golite062009
activin binding 0.883990007327631 bayes_pls_golite062009
transcription factor binding 0.803487897091874 bayes_pls_golite062009
small conjugating protein binding 0.68109357273955 bayes_pls_golite062009
ubiquitin binding 0.60123113960943 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 0.598436219078807 bayes_pls_golite062009
nuclear hormone receptor binding 0.470794254334721 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [451-494] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPGQCHIKVR RKNIFEDAYQ EIMRQTPEDL KKRLMIKFDG EEGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 664.0
Match: 1c4zA_
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [495-592] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYGGVSREFF FLLSHEMFNP FYCLFEYSAY DNYTIQINPN SGINPEHLNY FKFIGRVVGL  60
   61 GVFHRRFLDA FFVGALYKMM LRKKVVLQDM EGVDAEVY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [648-690] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQWRIVDRVQ EQFKAFMDGF NELIPEDLVT VFDERELELL IGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 664.0
Match: 1c4zA_
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [593-647] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSLNWMLENS IDGVLDLTFS ADDERFGEVV TVDLKPDGRN IEVTDGNKKE YVELY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [691-809] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAEIDIEDWK KHTDYRGYQE SDEVIQWFWK CVSEWDNEQR ARLLQFTTGT SRIPVNGFKD  60
   61 LQGSDGPRRF TIEKAGEVQQ LPKSHTCFNR VDLPQYVDYD SMKQKLTLAV EETIGFGQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 664.0
Match: 1c4zA_
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle