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Protein Overview: pub1

General Information:
Name(s) found: pub1 / SPAC11G7.02 [Sanger Pombe]
Description(s) found:
Found 22 descriptions.
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  • ubiquitin-protein ligase E3 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 767 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Golgi apparatus [IDALink to PubMed article]
    extrinsic to membrane [IEA]
    Biological Process: regulation of intracellular pH [IGILink to PubMed article]
    negative regulation of leucine import in response to ammonium ion [IMPLink to PubMed article]
    regulation of cell cycle [IGILink to PubMed article]
    regulation of transmembrane transport [IMPLink to PubMed article]
    protein ubiquitination [ICLink to PubMed article]
    ubiquitin-dependent protein catabolic process [IGILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSAQSRRI RVTIVAADGL YKRDVFRFPD PFAVLTVDGE QTHTTTAIKK TLNPYWNETF  60
   61 EVNVTDNSTI AIQVFDQKKF KKKGQGFLGV INLRVGDVLD LAIGGDEMLT RDLKKSNENT 120
  121 VVHGKIIINL STTAQSTLQV PSSAASGART QRTSITNDPQ SSQSSSVSRN PASSRAGSPT 180
  181 RDNAPAASPA SSEPRTFSSF EDQYGRLPPG WERRTDNLGR TYYVDHNTRS TTWIRPNLSS 240
  241 VAGAAAAELH SSASSANVTE GVQPSSSNAA RRTEASVLTS NATTAGSGEL PPGWEQRYTP 300
  301 EGRPYFVDHN TRTTTWVDPR RQQYIRSYGG PNNATIQQQP VSQLGPLPSG WEMRLTNTAR 360
  361 VYFVDHNTKT TTWDDPRLPS SLDQNVPQYK RDFRRKLIYF LSQPALHPLP GQCHIKVRRN 420
  421 HIFEDSYAEI MRQSATDLKK RLMIKFDGED GLDYGGLSRE YFFLLSHEMF NPFYCLFEYS 480
  481 SVDNYTLQIN PHSGINPEHL NYFKFIGRVI GLAIFHRRFV DAFFVVSFYK MILQKKVTLQ 540
  541 DMESMDAEYY RSLVWILDND ITGVLDLTFS VEDNCFGEVV TIDLKPNGRN IEVTEENKRE 600
  601 YVDLVTVWRI QKRIEEQFNA FHEGFSELIP QELINVFDER ELELLIGGIS EIDMEDWKKH 660
  661 TDYRSYSEND QIIKWFWELM DEWSNEKKSR LLQFTTGTSR IPVNGFKDLQ GSDGPRKFTI 720
  721 EKAGEPNKLP KAHTCFNRLD LPPYTSKKDL DHKLSIAVEE TIGFGQE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] PSI-BLAST 19.39794 No description for 2jqzA was found.
    2 View Details [130..290] FFAS03 2.48 NMR structure of WW domains (WW3-4) from Suppressor of Deltex
    3 View Details [291..379] PSI-BLAST 5.0 NMR structure of WW domains (WW3-4) from Suppressor of Deltex
    4 View Details [380..767] PSI-BLAST 140.0 Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.10194828712949 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.82547847405261 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.04482261304601 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.16615441408338 bayes_pls_golite062009
  • ligase activity
    		•  4.31802364495945 bayes_pls_golite062009
  • transcription activator activity
    		•  3.38259251431615 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.182048695645 bayes_pls_golite062009
  • binding
    		•  2.56070278040924 bayes_pls_golite062009
  • protein binding
    		•  2.42069774848849 bayes_pls_golite062009
  • transcription factor binding
    		•  1.94857953695695 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.79381302696181 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.7678419433602 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.67777735708173 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.67021314973391 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.9455445085372 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  0.863094487787088 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  0.863094487787088 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  0.863094487787088 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.782679886083722 bayes_pls_golite062009
  • catalytic activity
    		•  0.231344568578849 bayes_pls_golite062009
    3
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.19063870734022 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.90783262781184 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.09904629433884 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.1950291192201 bayes_pls_golite062009
  • ligase activity
    		•  4.32965319288714 bayes_pls_golite062009
  • transcription activator activity
    		•  3.61296179666474 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.2682543222543 bayes_pls_golite062009
  • binding
    		•  2.62219069341981 bayes_pls_golite062009
  • protein binding
    		•  2.51948432647454 bayes_pls_golite062009
  • transcription factor binding
    		•  2.18630749239417 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.07432061489599 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.02433252968502 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.90194027965368 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.81795522051605 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.121001087082 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.911388717587011 bayes_pls_golite062009
  • catalytic activity
    		•  0.210712504691113 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K36 specific)
    		•  0.173723075520888 bayes_pls_golite062009
    4
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.7414753295465 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.4871643691645 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.4323719338452 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  9.13168684685485 bayes_pls_golite062009
  • ligase activity
    		•  7.74494807432593 bayes_pls_golite062009
  • sodium channel inhibitor activity
    		•  6.01425793895251 bayes_pls_golite062009
  • phosphothreonine binding
    		•  5.90497053948475 bayes_pls_golite062009
  • phosphoserine binding
    		•  5.90497053948475 bayes_pls_golite062009
  • ion channel inhibitor activity
    		•  2.86572445544473 bayes_pls_golite062009
  • channel inhibitor activity
    		•  2.86572445544473 bayes_pls_golite062009
  • binding
    		•  2.51893471705946 bayes_pls_golite062009
  • protein binding
    		•  2.44418607577971 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.32249912875549 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.12515000812201 bayes_pls_golite062009
  • DNA binding
    		•  1.96906809911381 bayes_pls_golite062009
  • SMAD binding
    		•  1.72092268696303 bayes_pls_golite062009
    		• 1.3844044305632 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.38110732864799 bayes_pls_golite062009
  • R-SMAD binding
    		•  1.37268018792758 bayes_pls_golite062009
  • channel regulator activity
    		•  1.37005888814694 bayes_pls_golite062009
  • transcription activator activity
    		•  1.36023462068212 bayes_pls_golite062009
  • sodium channel regulator activity
    		•  1.19047973745862 bayes_pls_golite062009
  • receptor binding
    		•  1.15852292149378 bayes_pls_golite062009
  • catalytic activity
    		•  1.15152367676155 bayes_pls_golite062009
  • activin binding
    		•  0.883990007327631 bayes_pls_golite062009
  • transcription factor binding
    		•  0.803487897091874 bayes_pls_golite062009
  • small conjugating protein binding
    		•  0.68109357273955 bayes_pls_golite062009
  • ubiquitin binding
    		•  0.60123113960943 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  0.598436219078807 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.470794254334721 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle