| Protein: | HDA2 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 674 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HDA2.
| Description | E-value | Query Range |
Subject Range |
|
|
5.0E-62 | [73..668] | [843..1442] |
|
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4.0E-61 | [73..668] | [846..1445] |
|
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1.0E-60 | [73..668] | [57..656] |
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2.0E-60 | [73..668] | [848..1447] |
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2.0E-60 | [73..668] | [841..1440] |
|
Region A: Residues: [1-59] |
1 11 21 31 41 51
| | | | | |
1 MSRKNSKKLK VYYLPVTLTQ FQKDLSEILI SLHAKSFKAS IIGEPQADAV NKPSGLPAG
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.529 | c.47.1 | Thioredoxin-like |
| View | Download | 0.235 | a.4.1 | Homeodomain-like |
| View | Download | 0.334 | c.47.2 | RNA 3'-terminal phosphate cyclase, RPTC, insert domain |
|
Region A: Residues: [60-391] |
1 11 21 31 41 51
| | | | | |
1 PETHPYPTLS QRQLTYIFDS NIRAIANHPS LLVDHYMPRQ LLRMEPTESS IAGSHKFQVL 60
61 NQLINSICFR DREGSPNEVI KCAIIAHSIK ELDLLEGLIL GKKFRTKRLS GTSLYNEKHK 120
121 FPNLPTVDST INKDGTPNSV SSTSSNSNST SYTGYSKDDY DYSVKRNLKK RKINTDDWLF 180
181 LATTKHLKHD QYLLANYDID MIISFDPMLE VELPALQVLR NNANKDIPII KLLVQNSPDH 240
241 YLLDSEIKNS SVKSSHLSNN GHVDDSQEYE EIKSSLLYFL QARNAPVNNC EIDYIKLVKC 300
301 CLEGKDCNNI LPVLDLITLD EASKDSSDSG FW
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| Detection Method: | |
| Confidence: | 17.154902 |
| Match: | 1i84S_ |
| Description: | Heavy meromyosin subfragment |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [392-498] |
1 11 21 31 41 51
| | | | | |
1 QPQLTKLQYS STELPLWDGP LDIKTYQTEL MHRAVIRLRD IQDEYAKGTV PLYEKRLNET 60
61 QRQNQLDEIK NSVGLTFKKK QEVEKSINDS EKRLKHAMTE STKLQNK
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| Detection Method: | |
| Confidence: | 8.69897 |
| Match: | 1c1gA_ |
| Description: | Tropomyosin |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein deacetylase activity | 6.89067246450687 | bayes_pls_golite062009 |
| histone deacetylase activity | 6.72973102400173 | bayes_pls_golite062009 |
| deacetylase activity | 6.17788760083229 | bayes_pls_golite062009 |
| transcription regulator activity | 5.13863038737912 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 5.08778624990141 | bayes_pls_golite062009 |
| DNA binding | 4.66369707598026 | bayes_pls_golite062009 |
| nucleic acid binding | 4.51452285155271 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | 4.31765999651746 | bayes_pls_golite062009 |
| transcription factor activity | 4.06706589695599 | bayes_pls_golite062009 |
| transcription repressor activity | 3.55154985983449 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 3.16896789933192 | bayes_pls_golite062009 |
| binding | 3.02779747447702 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 2.41271657675151 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 1.90369937566383 | bayes_pls_golite062009 |
| histone acetyltransferase activity | 1.90369937566383 | bayes_pls_golite062009 |
| transcription activator activity | 1.77700860354597 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 1.73068440195944 | bayes_pls_golite062009 |
| chromatin binding | 1.68956710349366 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.62096064323298 | bayes_pls_golite062009 |
| transcription corepressor activity | 1.49423102874486 | bayes_pls_golite062009 |
| transcription factor binding | 1.40653841901929 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.84983974758882 | bayes_pls_golite062009 |
| protein binding | 0.830419844171551 | bayes_pls_golite062009 |
| N-acyltransferase activity | 0.712553030350746 | bayes_pls_golite062009 |
| histone binding | 0.557787598121402 | bayes_pls_golite062009 |
| N-acetyltransferase activity | 0.474709214154094 | bayes_pls_golite062009 |
| transcription coactivator activity | 0.2679415219517 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.141400887946529 | bayes_pls_golite062009 |
|
Region A: Residues: [499-674] |
1 11 21 31 41 51
| | | | | |
1 INHLLKNRQE LENFNKLPSN TISSENHLEE GSALADKLKE YIDKNATLFN KLKELQQANA 60
61 EKSKLNDELR SKYQIESSKA AESAQTLKIL QESMKSLENE VNGPLTKFST ESLKKELERL 120
121 QNDFQSLKAR NKFLKNYITL MNRQYDLKNK NNVQVEKAAA NGTRFRSTRS NTPNYT
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.392 | 0.074 | histone deacetylation | a.47.2 | t-snare proteins |
| View | Download | 0.470 | 0.074 | histone deacetylation | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.520 | 0.049 | histone deacetylation | a.24.2 | Aspartate receptor, ligand-binding domain |
| View | Download | 0.458 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.329 | N/A | N/A | a.69.1 | C-terminal domain of alpha and beta subunits of F1 ATP synthase |
| View | Download | 0.322 | N/A | N/A | a.25.1 | Ferritin-like |
| View | Download | 0.321 | N/A | N/A | a.23.1 | HSC20 (HSCB), C-terminal oligomerisation domain |
| View | Download | 0.318 | N/A | N/A | f.21.1 | Transmembrane di-heme cytochromes |
| View | Download | 0.315 | N/A | N/A | d.67.3 | Ribosome recycling factor, RRF |
| View | Download | 0.273 | N/A | N/A | a.25.1 | Ferritin-like |
| View | Download | 0.271 | N/A | N/A | a.29.3 | Acyl-CoA dehydrogenase C-terminal domain-like |
| View | Download | 0.253 | N/A | N/A | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.250 | N/A | N/A | a.25.1 | Ferritin-like |
| View | Download | 0.248 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.241 | N/A | N/A | a.24.5 | TMV-like viral coat proteins |
| View | Download | 0.240 | N/A | N/A | c.69.1 | alpha/beta-Hydrolases |
| View | Download | 0.239 | N/A | N/A | f.31.1 | Photosystem I reaction center subunit XI, PsaL |
| View | Download | 0.233 | N/A | N/A | a.7.1 | Spectrin repeat |
| View | Download | 0.222 | N/A | N/A | a.63.1 | Apolipophorin-III |
| View | Download | 0.215 | N/A | N/A | d.153.1 | N-terminal nucleophile aminohydrolases (Ntn hydrolases) |
| View | Download | 0.211 | N/A | N/A | f.25.1 | Cytochrome c oxidase subunit III-like |
| View | Download | 0.203 | N/A | N/A | f.35.1 | Multidrug efflux transporter AcrB transmembrane domain |
