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View Structure Prediction Details

Protein: YDR049W
Organism: Saccharomyces cerevisiae
Length: 632 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YDR049W.

Description E-value Query
Range		 Subject
Range
YDR049W - Zinc finger protein; putative transcription factor that may interact with proteins involved in histo...
VMS1_YEAST - Protein VMS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VMS1 PE=1 SV=1
 0.0 [1..632] [1..632]
VMS1_SCHPO - VMS1 homolog C1827.04 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC1827.04 PE=1 SV=...
SPCC1827.04 - ankyrin repeat protein, unknown biological role
 0.0 [11..631] [2..600]
gi|29824279, gi|... - gi|8570444|gb|AAF76471.1|AC020622_5 Contains similarity to an unnamed protein from Homo sapiens gb|A...
 0.0 [15..579] [18..526]
ANKZF1 - ankyrin repeat and zinc finger domain containing 1
 0.0 [19..429] [15..383]
CE26941 - Isopentenyl-diphosphate delta isomerase status:Confirmed UniProt:P34511 protein_id:AAF99988.2
 3.0E-95 [30..599] [4..581]
ZN622_MOUSE - Zinc finger protein 622 OS=Mus musculus GN=Znf622 PE=1 SV=1
 4.0E-44 [72..226] [4..180]
gi|45383850, gi|... - gi|45383850|ref|NP_989461.1| zinc finger protein 622 [Gallus gallus], gi|15419936|gb|AAK97212.1|AF29...
 8.0E-43 [72..201] [4..151]

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Predicted Domain #1
Region A:
Residues: [1-187] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSQKASKMT GSLKKNDLYI FDLSEQLLNS LKLMSFDSTL REVEVEKTSD NDRNKESGDL  60
   61 QIARKKVTSN VMRCSVCQMS FDSRNEQKAH YQTDYHLMNV KRNLRGLDIL SVEEFDALIS 120
  121 KEHGIKSEDE NSGGEQTSSD HEESEEASDR DPDLQTNNYM ETIIENDLQK LGFQKDESDA 180
  181 ISHINTQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.85972242708612 bayes_pls_golite062009
transcription regulator activity 2.77701617604772 bayes_pls_golite062009
DNA binding 2.71411659179983 bayes_pls_golite062009
binding 1.97525193898847 bayes_pls_golite062009
transcription factor activity 1.90143001800384 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.06438483834477 bayes_pls_golite062009
transcription activator activity 0.888241744617002 bayes_pls_golite062009
protein binding 0.721263040163177 bayes_pls_golite062009
transcription repressor activity 0.375362589875489 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
sequence-specific DNA binding 0.226250920465406 bayes_pls_golite062009
transcription factor binding 0.191965432731838 bayes_pls_golite062009
chromatin binding 0.131327938577204 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [188-305] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPYIYFKSKY LQKNEVLAIY KSLFNKRSLS NPNEALTFWN SQENPMAISA LFMVGGGHFA  60
   61 GAIVSHQRLN VKGNAHKKDE TLIEQAVNFL EHKTFHRYTT RRKQGGSQSA MDNAKGKA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.58699086730647 bayes_pls_golite062009
protein binding 1.41750957807465 bayes_pls_golite062009
transcription regulator activity 0.668531056539717 bayes_pls_golite062009
nucleic acid binding 0.403559033288365 bayes_pls_golite062009
DNA binding 0.186657583240225 bayes_pls_golite062009
ligase activity 0.0845684108313678 bayes_pls_golite062009
transcription factor binding 0.0182460237384001 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [306-462] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSAGSALRRY NESALKTDIQ GVLKDWEPYL SKCDNIFIRA RNVSDKKIFT DNTVLNKGDE  60
   61 RIKSFPFTTN RPTVLELKKA WCELSYLKIL PKPEPLAVKE TVQKLEVSNK KDEFKEKQEP 120
  121 LLEEIQTEEI ISLLKKGRAP LLISFLKKNK LDGNFRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.522879
Match: 1nfiE_
Description: I-kappa-B-alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [463-542] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPESKYSLTP TMLHYASQQG MKQMALILLS NIKCDPTIKN RLGRTAWDLN RNDDVRHAFQ  60
   61 IARYNLGESF TNWDETHIGQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.522879
Match: 1nfiE_
Description: I-kappa-B-alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [543-632] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLSREQVDEI NEKKKAIENE KAEKLIKLEL EAAKEKQRFA KDAERGPGKK LTNIPSIQQQ  60
   61 NLNSLTDEQR RRLMREQRAR AAEERMKKKY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.881 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle