YRC Public Data Repository - Protein Structure Prediction

Protein:	HHT1, HHT2
Organism:	Saccharomyces cerevisiae
Length:	136 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HHT1, HHT2.

Description	E-value	Query Range	Subject Range
gi\|255581420, gi... - gi\|255581420\|ref\|XP_002531518.1\| histone h3, putative [Ricinus communis], gi\|255545798\|ref\|XP_002513... gi\|357110657\|ref... - PREDICTED: histone H3.3-like isoform 2 [Brachypodium distachyon], PREDICTED: histone H3.3-like isofo... gi\|224814382 - gi\|224814382\|gb\|ACN65412.1\| histone 3.2 [Pteris vittata] gi\|92870265, gi\|... - gi\|92880830\|gb\|ABE85854.1\| Histone core [Medicago truncatula], gi\|92873912\|gb\|ABE82253.1\| Histone H3... gi\|224097140, gi... - gi\|224097140\|ref\|XP_002310848.1\| histone H3 [Populus trichocarpa], gi\|224093720\|ref\|XP_002309961.1\| ... gi\|116779721, gi... - gi\|224286639\|gb\|ACN41024.1\| unknown [Picea sitchensis], gi\|224284828\|gb\|ACN40144.1\| unknown [Picea s... gi\|118489220 - gi\|118489220\|gb\|ABK96416.1\| unknown [Populus trichocarpa x Populus deltoides] gi\|192910840, gi... - gi\|192910874\|gb\|ACF06545.1\| histone H3 [Elaeis guineensis], gi\|192910840\|gb\|ACF06528.1\| histone H3 [... gi\|212721898, gi... - gi\|238013324\|gb\|ACR37697.1\| unknown [Zea mays], gi\|212721898\|ref\|NP_001131417.1\| hypothetical protei... gi\|106879571 - gi\|106879571\|emb\|CAJ38369.1\| histin H3 [Plantago major] gi\|167998945, gi... - gi\|167999225\|ref\|XP_001752318.1\| histone H3 [Physcomitrella patens subsp. patens], gi\|167999057\|ref\|... H33_CAPAN - Histone H3.3 OS=Capsicum annuum PE=2 SV=3 H33_MEDSA - Histone H3.3 OS=Medicago sativa PE=1 SV=2 gi\|1435157, gi\|1... - gi\|151413347\|gb\|ABS11142.1\| histone H3 [Solanum lycopersicum], gi\|1435157\|emb\|CAA58445.1\| histone H3... H33_GOSHI - Histone H3.3 OS=Gossypium hirsutum GN=HIS3 PE=2 SV=3 H33_ORYCO - Histone H3.3 OS=Oryza coarctata PE=2 SV=3 H33_PINPS - Histone H3.3 OS=Pinus pinaster PE=2 SV=3 H33_LOLTE - Histone H3.3 OS=Lolium temulentum PE=2 SV=2 H33_ARATH - Histone H3.3 OS=Arabidopsis thaliana GN=HTR4 PE=1 SV=2 H33_VITVI - Histone H3.3 OS=Vitis vinifera PE=2 SV=3 H33_ORYSJ - Histone H3.3 OS=Oryza sativa subsp. japonica GN=H3 PE=1 SV=2 PGSC0003DMP40005... - PGSC0003DMT400009656, PGSC0003DMT400041662, PGSC0003DMT400043254, PGSC0003DMT400079216 gi\|115394199 - gi\|115394199\|gb\|ABI97039.1\| histone H3 [Robinia pseudoacacia] H33_ORYSA - Histone H3.3 (H3.2) - Oryza sativa (Rice) H33_ORYSI - Histone H3.3 OS=Oryza sativa subsp. indica GN=OsI_011536 PE=3 SV=1 gi\|144953503 - gi\|144953503\|gb\|ABP04114.1\| histone 3 [Lemna minor] gi\|62642117 - gi\|62642117\|gb\|AAX92697.1\| histone 3 [Picea abies] H33_LOLMU - Histone H3.3 OS=Lolium multiflorum GN=RH3 PE=2 SV=3 gi\|72398499, gi\|... - gi\|72398501\|gb\|AAZ72656.1\| histone H3.2 [Craterostigma plantagineum], gi\|72398499\|gb\|AAZ72655.1\| his... H33_TOBAC - Histone H3.3 OS=Nicotiana tabacum GN=H3 PE=1 SV=1 mgf001690m, mgf0... - null, null, null, null gi\|241915979, gi... - gi\|242094532\|ref\|XP_002437756.1\| hypothetical protein SORBIDRAFT_10g002040 [Sorghum bicolor], gi\|242... gi\|255625589 - gi\|255625589\|gb\|ACU13139.1\| unknown [Glycine max]	1.0E-52	[1..136]	[1..136]
H3F3B, H3F3A - H3 histone, family 3B (H3.3B), H3 histone, family 3A gi\|126635091, gi... - gi\|48290305\|emb\|CAF25046.1\| histone H3.3 [Oikopleura dioica], gi\|126635091\|emb\|CAK32534.1\| histone H... H33_SPISO - Histone H3.3 OS=Spisula solidissima PE=2 SV=2 H33_RABIT - Histone H3.3 OS=Oryctolagus cuniculus GN=H3F3A PE=2 SV=2 gi\|47215774, gi\|... - gi\|47224861\|emb\|CAG06431.1\| unnamed protein product [Tetraodon nigroviridis], gi\|47216831\|emb\|CAG027... H33_DROHY - Histone H3.3 OS=Drosophila hydei GN=His3.3A PE=3 SV=2 gi\|16580107 - gi\|16580107\|gb\|AAK61362.1\| histone 3A [Anopheles gambiae] gi\|125984400, gi... - gi\|54644282\|gb\|EAL33023.1\| GA19158 [Drosophila pseudoobscura pseudoobscura], gi\|125984400\|ref\|XP_001... gi\|66565026, gi\|... - gi\|66565026\|ref\|XP_624499.1\| PREDICTED: similar to H3 histone, family 3B [Apis mellifera], ref\|XP_39... H33_PIG - Histone H3.3 OS=Sus scrofa GN=H3F3A PE=2 SV=3 gi\|146741398 - gi\|146741398\|dbj\|BAF62355.1\| H3 histone, family 3A [Pan troglodytes verus] gi\|156548619, gi... - gi\|156548623\|ref\|XP_001608174.1\| PREDICTED: hypothetical protein [Nasonia vitripennis], gi\|156548619... gi\|149748720, gi... - gi\|149748720\|ref\|XP_001489292.1\| PREDICTED: similar to Histone H3.3B CG8989-PA [Equus caballus], gi\|... gi\|225703498 - gi\|225703498\|gb\|ACO07595.1\| Histone H3.3 [Oncorhynchus mykiss] gi\|149641481 - gi\|149641481\|ref\|XP_001514538.1\| PREDICTED: hypothetical protein [Ornithorhynchus anatinus] gi\|225706860, gi... - gi\|225706870\|gb\|ACO09281.1\| Histone H3.3 [Osmerus mordax], gi\|225706860\|gb\|ACO09276.1\| Histone H3.3 ... gi\|225713870, gi... - gi\|225713976\|gb\|ACO12834.1\| Histone H3.3 [Lepeophtheirus salmonis], gi\|225713870\|gb\|ACO12781.1\| Hist... gi\|225718784, gi... - gi\|225719256\|gb\|ACO15474.1\| Histone H3.3 [Caligus clemensi], gi\|225718784\|gb\|ACO15238.1\| Histone H3.... gi\|229367186 - gi\|229367186\|gb\|ACQ58573.1\| Histone H3.3 [Anoplopoma fimbria] cds.comp116638_c... - comp116638_c0_seq1\|g.9958 ORF comp116638_c0_seq1\|g.9958 comp116638_c0_seq1\|m.9958 type:complete len... gi\|291461559\|dbj... - histone H3 [Parasteatoda tepidariorum] gi\|662196103\|ref... - PREDICTED: histone H3.3 [Diaphorina citri], PREDICTED: histone H3.3 [Diaphorina citri], \| Histone H3... H33_MOUSE - Histone H3.3 OS=Mus musculus GN=H3f3a PE=1 SV=2 FBpp0309302, FBp... - The gene Histone H3.3B is referred to in FlyBase by the symbol Dmel\His3.3B (CG8989, FBgn0004828). I... gi\|149689030 - gi\|149689030\|gb\|ABR27830.1\| H3 histone family 3B [Triatoma infestans] SINCAMP000000190... - len=136 SINCAMT00000013358 SINCAMG00000008644, len=136 SINCAMT00000019228 SINCAMG00000012444 H33_DANRE - Histone H3.3 OS=Danio rerio GN=h3f3a PE=2 SV=3 gi\|60392147 - gi\|60392147\|gb\|AAX19363.1\| replacement histone H3.3 [Venerupis (Ruditapes) philippinarum] H33_BOVIN - Histone H3.3 OS=Bos taurus GN=H3F3A PE=1 SV=3 gi\|57089073, gi\|... - gi\|73964884\|ref\|XP_858804.1\| PREDICTED: similar to H3 histone, family 3B isoform 4 [Canis familiaris... H33_CHICK - Histone H3.3 OS=Gallus gallus GN=H3-IX PE=1 SV=2 gi\|51814315 - gi\|51814315\|gb\|AAU09479.1\| GekBS038P [Gekko japonicus] H33_XENTR - Histone H3.3 OS=Xenopus tropicalis GN=TGas113e22.1 PE=1 SV=3 gi\|30173649, gi\|... - ref\|XP_321243.1\| ENSANGP00000024222 [Anopheles gambiae], gi\|31241623\|ref\|XP_321242.1\| AGAP001813-PA... gi\|148727266, gi... - gi\|55589448\|ref\|XP_514240.1\| PREDICTED: similar to H3 histone, family 3B [Pan troglodytes], gi\|14872... gi\|195472777, gi... - gi\|38047789\|gb\|AAR09797.1\| similar to Drosophila melanogaster His3.3A [Drosophila yakuba], gi\|195479... H33_XENLA - Histone H3.3 OS=Xenopus laevis PE=1 SV=3 ENSCJAT000000246... - null, null, null, null, null tr\|M3W0N2\|M3W0N2... - Histone H3 OS=Felis catus GN=H3F3A PE=3 SV=1 gi\|126308440, gi... - gi\|126308440\|ref\|XP_001369390.1\| PREDICTED: hypothetical protein isoform 2 [Monodelphis domestica], ... gi\|123984391, gi... - gi\|220959794\|gb\|ACL92440.1\| His3.3A-PA [synthetic construct], gi\|220959296\|gb\|ACL92191.1\| His3.3A-PA... gi\|121543839, gi... - gi\|121543855\|gb\|ABM55592.1\| putative H3 histone, family 3B [Maconellicoccus hirsutus], gi\|121543839\|... gi\|91089507, gi\|... - gi\|91089509\|ref\|XP_975889.1\| PREDICTED: similar to Histone H3.3B CG8989-PA isoform 2 [Tribolium cast... gi\|109118266, gi... - gi\|109118278\|ref\|XP_001100294.1\| PREDICTED: similar to H3 histone, family 3B isoform 4 [Macaca mulat... gi\|109716251 - gi\|109716251\|gb\|ABG43104.1\| histone H3 [Pectinaria gouldii] gi\|108878058, gi... - gi\|157112482\|ref\|XP_001657554.1\| histone H3.3 [Aedes aegypti], gi\|108878058\|gb\|EAT42283.1\| histone H... gi\|148298806, gi... - gi\|87248155\|gb\|ABD36130.1\| h3 histone family 3a [Bombyx mori], gi\|148298806\|ref\|NP_001091756.1\| h3 h... gi\|90819998 - gi\|90819998\|gb\|ABD98756.1\| putative H3 histone, family 3A [Graphocephala atropunctata] gi\|195035003, gi... - gi\|195047686\|ref\|XP_001992391.1\| GH24723 [Drosophila grimshawi], gi\|195035003\|ref\|XP_001989021.1\| GH... gi\|190660632, gi... - gi\|194890669\|ref\|XP_001977366.1\| GG19000 [Drosophila erecta], gi\|194856509\|ref\|XP_001968765.1\| GG250... H33_RAT - Histone H3.3 OS=Rattus norvegicus GN=H3f3b PE=1 SV=2 gi\|194103311, gi... - gi\|195168426\|ref\|XP_002025032.1\| GL26831 [Drosophila persimilis], gi\|195161310\|ref\|XP_002021511.1\| G... gi\|193912260, gi... - gi\|195131317\|ref\|XP_002010097.1\| GI14879 [Drosophila mojavensis], gi\|195114260\|ref\|XP_002001685.1\| G... gi\|194141601, gi... - gi\|195400691\|ref\|XP_002058949.1\| GJ15308 [Drosophila virilis], gi\|195386334\|ref\|XP_002051859.1\| GJ17... gi\|194129232, gi... - gi\|195355011\|ref\|XP_002043987.1\| GM13676 [Drosophila sechellia], gi\|195342652\|ref\|XP_002037914.1\| GM... gi\|195576680, gi... - gi\|195576680\|ref\|XP_002078203.1\| GD23319 [Drosophila simulans], gi\|194190212\|gb\|EDX03788.1\| GD23319 ... gi\|195447814, gi... - gi\|195447814\|ref\|XP_002071382.1\| GK25162 [Drosophila willistoni], gi\|195432994\|ref\|XP_002064500.1\| G... gi\|170589399, gi... - gi\|170589399\|ref\|XP_001899461.1\| Histone H3.3 [Brugia malayi], gi\|170585288\|ref\|XP_001897416.1\| Hist... gi\|170063956, gi... - gi\|170063956\|ref\|XP_001867328.1\| histone H3.3 type 2 [Culex quinquefasciatus], gi\|167881403\|gb\|EDS44... gi\|190616692, gi... - gi\|194769246\|ref\|XP_001966717.1\| GF19171 [Drosophila ananassae], gi\|194761556\|ref\|XP_001962995.1\| GF... gi\|193688275, gi... - gi\|193688275\|ref\|XP_001949472.1\| PREDICTED: similar to Histone H3.3B CG8989-PA [Acyrthosiphon pisum]... gi\|224924434 - gi\|224924434\|gb\|ACN69167.1\| H3 histone family 3A [Stomoxys calcitrans] gi\|215493015, gi... - gi\|241112266\|ref\|XP_002399568.1\| Core histone H2A/H2B/H3/H4 [Ixodes scapularis], gi\|215493015\|gb\|EEC... gi\|198146737, gi... - gi\|198469150\|ref\|XP_002134231.1\| GA22698 [Drosophila pseudoobscura pseudoobscura], gi\|198146737\|gb\|E... gi\|198414843 - gi\|198414843\|ref\|XP_002119783.1\| PREDICTED: similar to Histone H3.3B CG8989-PA [Ciona intestinalis] gi\|224075146, gi... - gi\|224075146\|ref\|XP_002196488.1\| PREDICTED: hypothetical protein [Taeniopygia guttata], gi\|224047271... gi\|219428884, gi... - gi\|229280870\|gb\|EEN51635.1\| hypothetical protein BRAFLDRAFT_117519 [Branchiostoma floridae], gi\|2292... gi\|162415918 - gi\|162415918\|gb\|ABX89280.1\| histone cluster 1, H3a (predicted) [Papio anubis] gi\|149212750 - gi\|149212750\|gb\|ABR22618.1\| histone 3 [Aplysia californica] gi\|242020435, gi... - gi\|242020435\|ref\|XP_002430660.1\| histone H3.3 [Pediculus humanus corporis], gi\|212515835\|gb\|EEB17922... gi\|209732440, gi... - gi\|223672839\|gb\|ACN12601.1\| Histone H3.3 [Salmo salar], gi\|223672751\|gb\|ACN12557.1\| Histone H3.3 [Sa...	2.0E-52	[1..136]	[1..136]
gi\|156210495, gi... - gi\|156356095\|ref\|XP_001623766.1\| predicted protein [Nematostella vectensis], gi\|156210495\|gb\|EDO3166... gi\|190584176, gi... - gi\|196007812\|ref\|XP_002113772.1\| replacement histone H3.3 [Trichoplax adhaerens], gi\|190584176\|gb\|ED... gi\|221130419 - gi\|221130419\|ref\|XP_002154470.1\| PREDICTED: similar to Histone H3.3B CG8989-PA [Hydra magnipapillata... gi\|118776378 - gi\|118776378\|gb\|ABL14206.1\| histone H3.3-like protein protein [Trichinella spiralis] H33_TRIPS - Histone H3.3 OS=Trichinella pseudospiralis GN=HHT3 PE=2 SV=3	2.0E-52	[1..136]	[1..136]
gi\|18698662 - gi\|18698662\|gb\|AAL78367.1\|AF467728_1 disease-resistent-related protein [Oryza sativa]	2.0E-52	[1..136]	[1..136]
his-71 - Histone H3 status:Confirmed UniProt:Q10453 protein_id:AAB04902.1	3.0E-52	[1..136]	[1..136]
H3_ACRFO - Histone H3 OS=Acropora formosa PE=3 SV=2	4.0E-52	[1..136]	[1..136]

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Predicted Domain #1

Region A:
Residues: [1-136]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARTKQTARK STGGKAPRKQ LASKAARKSA PSTGGVKKPH RYKPGTVALR EIRRFQKSTE  60
   61 LLIRKLPFQR LVREIAQDFK TDLRFQSSAI GALQESVEAY LVSLFEDTNL AAIHAKRVTI 120
  121 QKKDIKLARR LRGERS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	542.626727
Match:	1id3A_
Description:	Histone H3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	6.43582244485566	bayes_pls_golite062009
DNA binding	4.49118409263799	bayes_pls_golite062009
nucleic acid binding	4.35201412176948	bayes_pls_golite062009
transcription regulator activity	4.08606081850613	bayes_pls_golite062009
binding	3.27510691458843	bayes_pls_golite062009
centromeric DNA binding	2.60445660474495	bayes_pls_golite062009
transcription factor activity	2.51581622888695	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.38228606466152	bayes_pls_golite062009
transcription repressor activity	2.3574713307436	bayes_pls_golite062009
transcription initiation factor activity	1.57176056919918	bayes_pls_golite062009
transcription corepressor activity	1.30859203490073	bayes_pls_golite062009
histone acetyltransferase activity	1.30425023787663	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.30425023787663	bayes_pls_golite062009
transcription activator activity	1.25487495162413	bayes_pls_golite062009
transcription factor binding	1.15204005455906	bayes_pls_golite062009
transcription coactivator activity	1.1297723528047	bayes_pls_golite062009
protein binding	1.07873333188144	bayes_pls_golite062009
transcription cofactor activity	1.01502031330902	bayes_pls_golite062009
histone binding	0.218942897869955	bayes_pls_golite062009
sequence-specific DNA binding	0.0852726470007639	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: