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View Structure Prediction Details

Protein: GEM1
Organism: Saccharomyces cerevisiae
Length: 662 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GEM1.

Description E-value Query
Range		 Subject
Range
GEM1_YEAST - Mitochondrial Rho GTPase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GEM1 PE=1 SV=...
GEM1 - Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochond...
 0.0 [1..662] [1..662]
gi|21361738, gi|... - ref|NP_060777.2| ras homolog gene family, member T1 [Homo sapiens], gi|12053353|emb|CAB66863.1| hyp...
 0.0 [3..612] [2..580]
MIRO2_ARATH - Mitochondrial Rho GTPase 2 OS=Arabidopsis thaliana GN=MIRO2 PE=2 SV=1
 0.0 [7..656] [16..641]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [7..656] [16..674]
SPCC320.04c - GTPase Gem1
GEM1_SCHPO - Mitochondrial Rho GTPase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gem1 PE=3 SV=1
 0.0 [6..662] [4..629]

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Predicted Domain #1
Region A:
Residues: [1-197] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKETIRVVI CGDEGVGKSS LIVSLTKAEF IPTIQDVLPP ISIPRDFSSS PTYSPKNTVL  60
   61 IDTSDSDLIA LDHELKSADV IWLVYCDHES YDHVSLFWLP HFRSLGLNIP VILCKNKCDS 120
  121 ISNVNANAMV VSENSDDDID TKVEDEEFIP ILMEFKEIDT CIKTSAKTQF DLNQAFYLCQ 180
  181 RAITHPISPL FDAMVGE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 106.522879
Match: 1i4dD_
Description: Rac
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 3.64858540496165 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.89122312915795 bayes_pls_golite062009
pyrophosphatase activity 2.81593838944939 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.79724985811732 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.79347973548337 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity 2.44176688200537 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
microfilament motor activity 2.38215814751368 bayes_pls_golite062009
motor activity 2.1532118704195 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
hydrolase activity 1.40217504818333 bayes_pls_golite062009
GTPase activity 1.23010905798386 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
protein transporter activity 1.05248757342537 bayes_pls_golite062009
actin-dependent ATPase activity 0.990320704369021 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
nucleic acid binding 0.777787753097919 bayes_pls_golite062009
cytoskeletal protein binding 0.568484017802328 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
DNA binding 0.479412476059825 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
receptor activity 0.381142123108547 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
transmembrane receptor activity 0.355770151889237 bayes_pls_golite062009
tubulin binding 0.326239364039846 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.226790072388501 bayes_pls_golite062009
microtubule binding 0.225323885896927 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.213018989352421 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
actin binding 0.0206144204131673 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [198-289] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKPLAVMALK RIFLLSDLNQ DSYLDDNEIL GLQKKCFNKS IDVNELNFIK DLLLDISKHD  60
   61 QEYINRKLYV PGKGITKDGF LVLNKIYAER GR

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.03
Match: 1a2xA
Description: Troponin C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.05873877511752 bayes_pls_golite062009
microfilament motor activity 1.9984373493184 bayes_pls_golite062009
metal ion binding 1.78612329591962 bayes_pls_golite062009
cation binding 1.78612329591962 bayes_pls_golite062009
ion binding 1.7794276789734 bayes_pls_golite062009
molecular transducer activity 1.57685201816793 bayes_pls_golite062009
signal transducer activity 1.57685201816793 bayes_pls_golite062009
cytoskeletal protein binding 1.52831937678894 bayes_pls_golite062009
actin-dependent ATPase activity 1.26291497318874 bayes_pls_golite062009
motor activity 1.22884221769274 bayes_pls_golite062009
transporter activity 1.18173318787461 bayes_pls_golite062009
protein binding 1.09433047543741 bayes_pls_golite062009
transmembrane transporter activity 0.967232199555998 bayes_pls_golite062009
calcium ion binding 0.96333115642547 bayes_pls_golite062009
enzyme regulator activity 0.898362179169385 bayes_pls_golite062009
substrate-specific transporter activity 0.713088884599039 bayes_pls_golite062009
actin binding 0.571065725792783 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.471661454726807 bayes_pls_golite062009
transcription regulator activity 0.467743512816825 bayes_pls_golite062009
active transmembrane transporter activity 0.255162242356474 bayes_pls_golite062009
enzyme activator activity 0.224800334961602 bayes_pls_golite062009
ion transmembrane transporter activity 0.206190076128058 bayes_pls_golite062009
nucleic acid binding 0.137921428032586 bayes_pls_golite062009
DNA binding 0.126696463568471 bayes_pls_golite062009
tubulin binding 0.121694931665203 bayes_pls_golite062009
gated channel activity 0.0726874243760007 bayes_pls_golite062009
cation transmembrane transporter activity 0.0385263849284123 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [290-430] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HETTWAILRT FHYTDSLCIN DKILHPRLVV PDTSSVELSP KGYRFLVDIF LKFDIDNDGG  60
   61 LNNQELHRLF KCTPGLPKLW TSTNFPFSTV VNNKGCITLQ GWLAQWSMTT FLNYSTTTAY 120
  121 LVYFGFQEDA RLALQVTKPR K

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.03
Match: 1a2xA
Description: Troponin C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 3.64858540496165 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.89122312915795 bayes_pls_golite062009
pyrophosphatase activity 2.81593838944939 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.79724985811732 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.79347973548337 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity 2.44176688200537 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
microfilament motor activity 2.38215814751368 bayes_pls_golite062009
motor activity 2.1532118704195 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
hydrolase activity 1.40217504818333 bayes_pls_golite062009
GTPase activity 1.23010905798386 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
protein transporter activity 1.05248757342537 bayes_pls_golite062009
actin-dependent ATPase activity 0.990320704369021 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
nucleic acid binding 0.777787753097919 bayes_pls_golite062009
cytoskeletal protein binding 0.568484017802328 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
DNA binding 0.479412476059825 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
receptor activity 0.381142123108547 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
transmembrane receptor activity 0.355770151889237 bayes_pls_golite062009
tubulin binding 0.326239364039846 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.226790072388501 bayes_pls_golite062009
microtubule binding 0.225323885896927 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.213018989352421 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
actin binding 0.0206144204131673 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [431-662] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRRSGKLYR SNINDRKVFN CFVIGKPCCG KSSLLEAFLG RSFSEEYSPT IKPRIAVNSL  60
   61 ELKGGKQYYL ILQELGEQEY AILENKDKLK ECDVICLTYD SSDPESFSYL VSLLDKFTHL 120
  121 QDLPLVFVAS KADLDKQQQR CQIQPDELAD ELFVNHPLHI SSRWLSSLNE LFIKITEAAL 180
  181 DPGKNTPGLP EETAAKDVDY RQTALIFGST VGFVALCSFT LMKLFKSSKF SK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.9897
Match: 1ceeA_
Description: CDC42
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle