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View Structure Prediction Details

Protein: gi|56554456, gi|...
Organism: Homo sapiens
Length: 291 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|56554456, gi|....

Description E-value Query
Range		 Subject
Range
gi|114608944 - gi|114608944|ref|XP_001158524.1| PREDICTED: protein-tyrosine kinase fyn isoform 5 [Pan troglodytes]
 279.0 [0..8] [284..261]
FYN_XIPHE - Tyrosine-protein kinase Fyn OS=Xiphophorus helleri GN=fyn PE=2 SV=3
 279.0 [0..8] [284..261]
gi|61652774 - gi|61652774|gb|AAX47959.1| Fyn Kinase [Danio rerio]
 279.0 [0..8] [284..261]
gi|56788733, gi|... - gi|58332784|ref|NP_001011413.1| v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [Xenopus (...
 278.0 [0..6] [284..254]
gi|76625629 - gi|76625629|ref|XP_881622.1| PREDICTED: similar to fyn proto-oncogene isoform 9 [Bos taurus]
 278.0 [0..8] [284..261]
SRC_CHICK - Proto-oncogene tyrosine-protein kinase Src OS=Gallus gallus GN=SRC PE=1 SV=4
 278.0 [0..6] [284..255]
SRC2_XENLA - Tyrosine-protein kinase Src-2 OS=Xenopus laevis GN=src-b PE=2 SV=3
 278.0 [0..6] [284..254]
SRC_AVISS - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S1) GN=V-SRC PE=3 SV...
 278.0 [0..6] [285..255]

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Predicted Domain #1
Region A:
Residues: [1-291] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALEEIRPKE VYLDRKLLTL EDKELGSGNF GTVKKGYYQM KKVVKTVAVK ILKNEANDPA  60
   61 LKDELLAEAN VMQQLDNPYI VRMIGICEAE SWMLVMEMAE LGPLNKYLQQ NRHVKDKNII 120
  121 ELVHQVSMGM KYLEESNFVH RDLAARNVLL VTQHYAKISD FGLSKALRAD ENYYKAQTHG 180
  181 KWPVKWYAPE CINYYKFSSK SDVWSFGVLM WEAFSYGQKP YRGMKGSEVT AMLEKGERMG 240
  241 CPAGCPREMY DLMNLCWTYD VENRPGFAAV ELRLRNYYYD VVNEGHHHHH H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.154902
Match: 1xbaA
Description: Crystal structure of apo syk tyrosine kinase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 5.4586557943719 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.04467222534257 bayes_pls_golite062009
kinase activity 4.85903980916957 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.63692708178478 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
transferase activity 3.26787750561728 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.66669268613198 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
integrin binding 1.44154155381408 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
insulin receptor substrate binding 0.95914323793919 bayes_pls_golite062009
phosphoinositide 3-kinase binding 0.91037901281763 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
transporter activity 0.710766490066447 bayes_pls_golite062009
MAP kinase kinase activity 0.610230065465794 bayes_pls_golite062009
transmembrane transporter activity 0.60324822483033 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
substrate-specific transporter activity 0.385603245903806 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 0.349343975617553 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
receptor binding 0.197402253061255 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.152203945257581 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle