YRC Public Data Repository - Protein Structure Prediction

Protein:	EG11506
Organism:	Escherichia coli K-12
Length:	644 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG11506.

Description	E-value	Query Range	Subject Range
gi\|75240799 - gi\|75240799\|ref\|ZP_00724697.1\| COG0465: ATP-dependent Zn proteases [Escherichia coli F11]	638.0	[0..1]	[644..1]
gi\|82778492, gi\|... - gi\|82778492\|ref\|YP_404841.1\| ATP-dependent metalloprotease [Shigella dysenteriae Sd197], gi\|81242640...	638.0	[0..1]	[644..1]
FTSH_SALTI - Cell division protease ftsH OS=Salmonella typhi GN=hflB PE=3 SV=1 FTSH_SALTY - Cell division protease ftsH OS=Salmonella typhimurium GN=hflB PE=3 SV=1 gi\|214000933 - gi\|214000933\|ref\|ZP_03411668.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica s... gi\|224585091, gi... - gi\|224585091\|ref\|YP_002638890.1\| cell division protein [Salmonella enterica subsp. enterica serovar ... gi\|56129482, gi\|... - gi\|56415225\|ref\|YP_152300.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica sero... gi\|238910089 - gi\|238910089\|ref\|ZP_04653926.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica s... gi\|207858544, gi... - gi\|207858544\|ref\|YP_002245195.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica ... gi\|213052988 - gi\|213052988\|ref\|ZP_03345866.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica s... lcl\|NC_016856.1_... - [gene=hflB] [protein=ATP-dependent metalloprotease] [protein_id=YP_005239474.1] [location=complement... gi\|213425426 - gi\|213425426\|ref\|ZP_03358176.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica s... gi\|213852786 - gi\|213852786\|ref\|ZP_03382318.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica s... gi\|29143547, gi\|... - gi\|29143547\|ref\|NP_806889.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica sero... gi\|160867488, gi... - gi\|161506141\|ref\|YP_001573253.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. arizonae ... FTSH_SALTY - ATP-dependent zinc metalloprotease FtsH OS=Salmonella typhimurium GN=ftsH PE=3 SV=1 gi\|16762058 - gi\|16762058\|ref\|NP_457675.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica sero... gi\|161616303, gi... - gi\|161616303\|ref\|YP_001590268.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica ... FTSH_SALTI - ATP-dependent zinc metalloprotease FtsH OS=Salmonella typhi GN=ftsH PE=3 SV=1 gi\|197364155, gi... - gi\|197364155\|ref\|YP_002143792.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica ... FTSH_SALTY - ATP-dependent zinc metalloprotease FtsH OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 7007... gi\|205273978, gi... - gi\|205354197\|ref\|YP_002227998.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica ...	638.0	[0..1]	[644..1]
gi\|81246995, gi\|... - gi\|82545584\|ref\|YP_409531.1\| ATP-dependent metalloprotease [Shigella boydii Sb227], gi\|81246995\|gb\|A...	638.0	[0..1]	[644..1]
gi\|746401 - gi\|746401\|gb\|AAA97508.1\| ATP-binding protein gi\|188487047, gi... - gi\|188491848\|ref\|ZP_02999118.1\| ATP-dependent metallopeptidase HflB [Escherichia coli 53638], gi\|188... gi\|157068341, gi... - gi\|157162661\|ref\|YP_001459979.1\| ATP-dependent metalloprotease [Escherichia coli HS], gi\|157068341\|g... gi\|157080734, gi... - gi\|157158704\|ref\|YP_001464653.1\| ATP-dependent metalloprotease [Escherichia coli E24377A], gi\|157080... gi\|226839967, gi... - gi\|254038343\|ref\|ZP_04872401.1\| ATP-dependent metalloprotease [Escherichia sp. 1_1_43], gi\|226839967... gi\|253771988, gi... - gi\|253771988\|ref\|YP_003034819.1\| ATP-dependent metalloprotease FtsH [Escherichia coli BL21(DE3)], gi... gi\|237706070, gi... - gi\|237706070\|ref\|ZP_04536551.1\| ATP-dependent metalloprotease [Escherichia sp. 3_2_53FAA], gi\|226899... gi\|194411725, gi... - gi\|194430224\|ref\|ZP_03062722.1\| ATP-dependent metallopeptidase HflB [Escherichia coli B171], gi\|1944... tr\|A0A0G3HSQ2\|A0... - ATP-dependent zinc metalloprotease FtsH OS=Escherichia coli (strain K12) GN=ftsH PE=3 SV=1 gi\|191168060, gi... - gi\|191168060\|ref\|ZP_03029860.1\| ATP-dependent metallopeptidase HflB [Escherichia coli B7A], gi\|19090...	638.0	[0..1]	[644..4]
gi\|205357195, gi... - gi\|205357195\|ref\|ZP_02345811.2\| ATP-dependent metallopeptidase HflB [Salmonella enterica subsp. ente... gi\|197248059, gi... - gi\|197248059\|ref\|YP_002148220.1\| ATP-dependent metallopeptidase HflB [Salmonella enterica subsp. ent... gi\|195873641, gi... - gi\|195873641\|ref\|ZP_02697399.2\| ATP-dependent metallopeptidase HflB [Salmonella enterica subsp. ente... gi\|194471603, gi... - gi\|194471603\|ref\|ZP_03077587.1\| ATP-dependent metallopeptidase HflB [Salmonella enterica subsp. ente... gi\|194447870, gi... - gi\|194447870\|ref\|YP_002047324.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica ... gi\|194442507, gi... - gi\|194442507\|ref\|YP_002042552.1\| ATP-dependent metallopeptidase HflB [Salmonella enterica subsp. ent... gi\|205348591, gi... - gi\|205360607\|ref\|ZP_02684667.2\| ATP-dependent metallopeptidase HflB [Salmonella enterica subsp. ente... gi\|205343557, gi... - gi\|205359745\|ref\|ZP_02831638.2\| ATP-dependent metallopeptidase HflB [Salmonella enterica subsp. ente... gi\|205359196, gi... - gi\|205359196\|ref\|ZP_02668061.2\| ATP-dependent metallopeptidase HflB [Salmonella enterica subsp. ente... gi\|62181804, gi\|... - gi\|62181804\|ref\|YP_218221.1\| ATP-dependent metalloprotease [Salmonella enterica subsp. enterica sero... gi\|205333758, gi... - gi\|205358490\|ref\|ZP_02656962.2\| ATP-dependent metallopeptidase HflB [Salmonella enterica subsp. ente...	637.0	[0..1]	[644..4]
FTSH_ECO57 - ATP-dependent zinc metalloprotease FtsH OS=Escherichia coli O157:H7 GN=ftsH PE=3 SV=1 gi\|13363530, gi\|... - gi\|15833311\|ref\|NP_312084.1\| ATP-dependent metalloprotease [Escherichia coli O157:H7 str. Sakai], gi... gi\|254594527, gi... - gi\|254795127\|ref\|YP_003079964.1\| subunit of integral membrane ATP-dependent zinc metallopeptidase [E... gi\|209758260, gi... - pir\|\|D85981 cell division protein HflB/FtsH proteinase [imported] - Escherichia coli (strain O157:H7... gi\|209160879, gi... - gi\|209399479\|ref\|YP_002272648.1\| ATP-dependent metallopeptidase HflB [Escherichia coli O157:H7 str. ... gi\|195938397 - gi\|195938397\|ref\|ZP_03083779.1\| ATP-dependent metalloprotease [Escherichia coli O157:H7 str. EC4024] gi\|15803718, gi\|... - gi\|15803718\|ref\|NP_289752.1\| ATP-dependent metalloprotease [Escherichia coli O157:H7 EDL933], gi\|125... gi\|217319989, gi... - gi\|217327622\|ref\|ZP_03443705.1\| ATP-dependent metallopeptidase HflB [Escherichia coli O157:H7 str. T...	636.0	[0..1]	[644..1]
gi\|75260106 - gi\|75260106\|ref\|ZP_00731384.1\| COG0465: ATP-dependent Zn proteases [Escherichia coli E22]	628.0	[0..6]	[644..1]
gi\|75176220 - gi\|75176220\|ref\|ZP_00696372.1\| COG0465: ATP-dependent Zn proteases [Shigella boydii BS512]	628.0	[0..5]	[644..1]
gi\|77974013 - gi\|77974013\|ref\|ZP_00829556.1\| COG0465: ATP-dependent Zn proteases [Yersinia frederiksenii ATCC 3364...	626.0	[0..1]	[644..1]

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Predicted Domain #1

Region A:
Residues: [1-145]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKNLILWLV IAVVLMSVFQ SFGPSESNGR KVDYSTFLQE VNNDQVREAR INGREINVTK  60
   61 KDSNRYTTYI PVQDPKLLDN LLTKNVKVVG EPPEEPSLLA SIFISWFPML LLIGVWIFFM 120
  121 RQMQGGGGKG AMSFGKSKAR MLTED

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	27.69897
Match:	PF06480.6
Description:	No description for PF06480.6 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [146-644]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIKTTFADVA GCDEAKEEVA ELVEYLREPS RFQKLGGKIP KGVLMVGPPG TGKTLLAKAI  60
   61 AGEAKVPFFT ISGSDFVEMF VGVGASRVRD MFEQAKKAAP CIIFIDEIDA VGRQRGAGLG 120
  121 GGHDEREQTL NQMLVEMDGF EGNEGIIVIA ATNRPDVLDP ALLRPGRFDR QVVVGLPDVR 180
  181 GREQILKVHM RRVPLAPDID AAIIARGTPG FSGADLANLV NEAALFAARG NKRVVSMVEF 240
  241 EKAKDKIMMG AERRSMVMTE AQKESTAYHE AGHAIIGRLV PEHDPVHKVT IIPRGRALGV 300
  301 TFFLPEGDAI SASRQKLESQ ISTLYGGRLA EEIIYGPEHV STGASNDIKV ATNLARNMVT 360
  361 QWGFSEKLGP LLYAEEEGEV FLGRSVAKAK HMSDETARII DQEVKALIER NYNRARQLLT 420
  421 DNMDILHAMK DALMKYETID APQIDDLMAR RDVRPPAGWE EPGASNNSGD NGSPKAPRPV 480
  481 DEPRTPNPGN TMSEQLGDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	115.0
Match:	2ce7A
Description:	EDTA treated
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	4.71605970197038	bayes_pls_golite062009
peptidase activity	3.6994352506738	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.52737232558306	bayes_pls_golite062009
endopeptidase activity	3.48761031707503	bayes_pls_golite062009
transporter activity	2.69706219265144	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.69246499202248	bayes_pls_golite062009
pyrophosphatase activity	2.61582393123755	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.59641929642359	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.59333672868803	bayes_pls_golite062009
transmembrane transporter activity	2.58635717382512	bayes_pls_golite062009
motor activity	2.32425703346903	bayes_pls_golite062009
primary active transmembrane transporter activity	2.3117065785582	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.3087157955244	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.27169846706667	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.26732942861417	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.2667183895378	bayes_pls_golite062009
microtubule motor activity	2.26003723459523	bayes_pls_golite062009
binding	2.21604035604783	bayes_pls_golite062009
active transmembrane transporter activity	2.18463291739284	bayes_pls_golite062009
ATPase activity, coupled	2.14546190519918	bayes_pls_golite062009
ATPase activity	2.11122403732968	bayes_pls_golite062009
substrate-specific transporter activity	1.59061231802385	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.26476212402779	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
purine nucleotide binding	0.725611289205392	bayes_pls_golite062009
nucleotide binding	0.717697610309727	bayes_pls_golite062009
purine ribonucleotide binding	0.713814218071151	bayes_pls_golite062009
ribonucleotide binding	0.713752628021599	bayes_pls_golite062009
ion transmembrane transporter activity	0.703036644931229	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
guanyl nucleotide binding	0.399434758448606	bayes_pls_golite062009
GTP binding	0.398333597279278	bayes_pls_golite062009
guanyl ribonucleotide binding	0.39332178627529	bayes_pls_golite062009
cation transmembrane transporter activity	0.294004084202727	bayes_pls_golite062009
signal transducer activity	0.286367085584159	bayes_pls_golite062009
molecular transducer activity	0.286367085584159	bayes_pls_golite062009
cytoskeletal protein binding	0.205488803771958	bayes_pls_golite062009
nucleic acid binding	0.192553066860219	bayes_pls_golite062009
ATP binding	0.19169045543599	bayes_pls_golite062009
protein transporter activity	0.178442534411253	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
adenyl ribonucleotide binding	0.165732470448462	bayes_pls_golite062009
adenyl nucleotide binding	0.162060759063149	bayes_pls_golite062009
signal recognition particle binding	0.00643331355694032	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: