YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30256909, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	345 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30256909, gi|....

Description	E-value	Query Range	Subject Range
gi\|40795502 - gi\|40795502\|gb\|AAR91477.1\| thermostable alcohol dehydrogenase [Geobacillus sp. M10EXG]	0.0	[1..341]	[1..340]
ADH3_GEOSE - Alcohol dehydrogenase OS=Geobacillus stearothermophilus PE=1 SV=1	0.0	[1..339]	[1..338]
gi\|56419266, gi\|... - gi\|56419266\|ref\|YP_146584.1\| alcohol dehydrogenase [Geobacillus kaustophilus HTA426], gi\|56379108\|db...	8.0E-99	[1..337]	[1..336]
gi\|56961828, gi\|... - gi\|56961828\|ref\|YP_173550.1\| alcohol dehydrogenase [Bacillus clausii KSM-K16], gi\|56908062\|dbj\|BAD62...	1.0E-97	[1..340]	[10..348]
gi\|222055606, gi... - gi\|222055606\|ref\|YP_002537968.1\| Alcohol dehydrogenase zinc-binding domain protein [Geobacter sp. FR...	1.0E-94	[1..337]	[6..341]
gi\|88858591, gi\|... - gi\|88858591\|ref\|ZP_01133232.1\| alcohol dehydrogenase, zinc-containing [Pseudoalteromonas tunicata D2...	3.0E-93	[1..337]	[1..336]
gi\|71146479, gi\|... - gi\|71280739\|ref\|YP_270515.1\| alcohol dehydrogenase, zinc-containing [Colwellia psychrerythraea 34H],...	1.0E-92	[1..337]	[1..336]
gi\|148559159, gi... - gi\|148559159\|ref\|YP_001258230.1\| alcohol dehydrogenase, zinc-containing [Brucella ovis ATCC 25840], ... gi\|161618188, gi... - gi\|161618188\|ref\|YP_001592075.1\| alcohol dehydrogenase [Brucella canis ATCC 23365], gi\|161334999\|gb\|... gi\|163842470, gi... - gi\|163842470\|ref\|YP_001626874.1\| alcohol dehydrogenase [Brucella suis ATCC 23445], gi\|163673193\|gb\|A... gi\|189019022, gi... - gi\|189023450\|ref\|YP_001934218.1\| Zinc-containing alcohol dehydrogenase [Brucella abortus S19], gi\|18... gi\|82699116 - gi\|82699116\|ref\|YP_413690.1\| zinc-containing alcohol dehydrogenase [Brucella melitensis biovar Abort... gi\|62289176, gi\|... - gi\|62289176\|ref\|YP_220969.1\| alcohol dehydrogenase, zinc-containing [Brucella abortus bv. 1 str. 9-9... gi\|82615217 - gi\|82615217\|emb\|CAJ10160.1\| Zinc-containing alcohol dehydrogenase superfamily:Zinc-containing alcoho... gi\|23346983, gi\|... - gi\|23501112\|ref\|NP_697239.1\| alcohol dehydrogenase, zinc-containing [Brucella suis 1330], gi\|2334698... gi\|225851734, gi... - gi\|225851734\|ref\|YP_002731967.1\| Alcohol dehydrogenase [Brucella melitensis ATCC 23457], gi\|22564009... gi\|254696625 - gi\|254696625\|ref\|ZP_05158453.1\| Alcohol dehydrogenase [Brucella abortus bv. 2 str. 86/8/59] gi\|254701004 - gi\|254701004\|ref\|ZP_05162832.1\| Alcohol dehydrogenase [Brucella suis bv. 5 str. 513] gi\|254690501 - gi\|254690501\|ref\|ZP_05153755.1\| Alcohol dehydrogenase [Brucella abortus bv. 6 str. 870] gi\|254694991 - gi\|254694991\|ref\|ZP_05156819.1\| Alcohol dehydrogenase [Brucella abortus bv. 3 str. Tulya] gi\|254709348 - gi\|254709348\|ref\|ZP_05171159.1\| Alcohol dehydrogenase [Brucella pinnipedialis B2/94] gi\|254713230 - gi\|254713230\|ref\|ZP_05175041.1\| Alcohol dehydrogenase [Brucella ceti M644/93/1] gi\|254705379 - gi\|254705379\|ref\|ZP_05167207.1\| Alcohol dehydrogenase [Brucella suis bv. 3 str. 686] gi\|254707110 - gi\|254707110\|ref\|ZP_05168938.1\| Alcohol dehydrogenase [Brucella pinnipedialis M163/99/10] gi\|254731535 - gi\|254731535\|ref\|ZP_05190113.1\| Alcohol dehydrogenase [Brucella abortus bv. 4 str. 292] gi\|254716416 - gi\|254716416\|ref\|ZP_05178227.1\| Alcohol dehydrogenase [Brucella ceti M13/05/1] gi\|254718415 - gi\|254718415\|ref\|ZP_05180226.1\| Alcohol dehydrogenase [Brucella sp. 83/13]	1.0E-92	[1..337]	[5..342]

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Predicted Domain #1

Region A:
Residues: [1-345]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAVVVNKNS KANIEVVEKE LRPLHSGEAL VDVEYCGVCH TDLHVANHDF GNTDGRILGH  60
   61 EGVGIVTKIA DDVTSLKVGD RVSIAWMFQS CGRCEYCVTG RETFCREVKN AGYSVDGGMA 120
  121 EQCIVTADYA VKVPEGLDPA QASSITCAGV TTYKAIKVSD IKPGQPIVIY GCGGLGNLAI 180
  181 QYAKNVFGAK VIAVDINDDK LALAKEVGAD MTINPISQGP ADKIIQEEFG GAYAAVVTAV 240
  241 SKVAFNSAVD AVRACGKVVA VGLPVETMDL NIPRLVLDGI EVVGSLVGTR KDLEEAFMFG 300
  301 AEGKVVPVVQ TCSLDKVQNV FEEMEQGRIQ GRMVIDFKQN NCDCK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	103.0
Match:	1rjwA
Description:	CRYSTAL STRUCTURE OF NAD(+)-DEPENDENT ALCOHOL DEHYDROGENASE FROM BACILLUS STEAROTHERMOPHILUS STRAIN LLD-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ethanol binding	4.47659026306883	bayes_pls_golite062009
NAD or NADH binding	4.35058438816264	bayes_pls_golite062009
retinol dehydrogenase activity	4.1750549780559	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
methylglyoxal reductase (NADH-dependent) activity	3.00190838171391	bayes_pls_golite062009
L-iditol 2-dehydrogenase activity	3.00103406168296	bayes_pls_golite062009
alcohol binding	2.97042200128883	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
retinol binding	2.89007863838685	bayes_pls_golite062009
all-trans retinal binding	2.84803957533249	bayes_pls_golite062009
S-(hydroxymethyl)glutathione dehydrogenase activity	2.58673703881996	bayes_pls_golite062009
hydroxymethylfurfural reductase activity	2.2999175117758	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADH) activity	2.2999175117758	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
NADPH:quinone reductase activity	2.16668841986245	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.03039843216597	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	1.87993822355695	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
DNA binding	1.61355789916908	bayes_pls_golite062009
transcription regulator activity	1.55390653047158	bayes_pls_golite062009
nucleic acid binding	1.48478425318425	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.38219425408212	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.22444609393125	bayes_pls_golite062009
chaperone binding	1.19079350615542	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.07006097264025	bayes_pls_golite062009
retinoid binding	1.04593455330515	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.01627645289834	bayes_pls_golite062009
binding	0.982999356179965	bayes_pls_golite062009
isoprenoid binding	0.93398178725124	bayes_pls_golite062009
transcription factor activity	0.91090893050278	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.788034697021177	bayes_pls_golite062009
structural molecule activity	0.75267483298133	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.621273823467575	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADPH) activity	0.382131941157781	bayes_pls_golite062009
L-arabinitol 2-dehydrogenase activity	0.382131941157781	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
transporter activity	0.329910229428347	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	0.320177384202291	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.250698007650211	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.216422278300306	bayes_pls_golite062009
transmembrane transporter activity	0.193114727419042	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.169301675015808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.162625185692811	bayes_pls_golite062009
fatty acid synthase activity	0.0962368786590111	bayes_pls_golite062009
transition metal ion binding	0.0196464192589003	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: