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View Structure Prediction Details

Protein: gi|30259414, gi|...
Organism: Bacillus anthracis str. Ames
Length: 388 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30259414, gi|....

Description E-value Query
Range
Subject
Range
gi|114555329 - gi|114555329|ref|XP_519834.2| PREDICTED: similar to histone deacetylase HD1 isoform 6 [Pan troglodyt...
0.0 [5..385] [13..413]
HDAC1_CHICK - Histone deacetylase 1 OS=Gallus gallus GN=HDAC1 PE=2 SV=1
0.0 [5..361] [13..387]
HDAC1_MOUSE - Histone deacetylase 1 OS=Mus musculus GN=Hdac1 PE=1 SV=1
0.0 [5..361] [13..387]
HDAC1_RAT - Histone deacetylase 1 OS=Rattus norvegicus GN=Hdac1 PE=1 SV=1
0.0 [5..361] [13..387]
HDAC1_BOVIN - Histone deacetylase 1 OS=Bos taurus GN=HDAC1 PE=2 SV=1
0.0 [5..361] [13..387]
gi|61369536, gi|... - gi|61369536|gb|AAX43347.1| histone deacetylase 1 [synthetic construct], gi|30583783|gb|AAP36140.1| H...
0.0 [5..361] [13..387]
HDAC1_PONPY - Histone deacetylase 1 - Pongo pygmaeus (Orangutan)
HDAC1 - histone deacetylase 1
gi|123995803, gi... - gi|61363144|gb|AAX42342.1| histone deacetylase 1 [synthetic construct], gi|60814459|gb|AAX36302.1| h...
HDAC1_PONAB - Histone deacetylase 1 OS=Pongo abelii GN=HDAC1 PE=2 SV=1
0.0 [5..361] [13..387]

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Predicted Domain #1
Region A:
Residues: [1-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSAFIYSDD FRGYSFSPDH PFNQLRVTLT YDLLQKGGFI SPSQIISPRM ATDEEIAYIH  60
   61 TEEYINAVKR AGEGKLEKSI AMTYGLGTED TPMFPNMHEA SALLVGGTLT AVDAVLSGKV 120
  121 KHALNLGGGL HHGFRGKASG FCIYNDSSIA MKYIQKKYGL RVLYIDTDAH HGDGVQWSFY 180
  181 DDPNVCTISL HETGRYLFPG TGAVNERGQG NGYSYSFNVP LDAFTEDESF LDSYRTVVKE 240
  241 VAAYFKPDII LTQNGADAHY YDPLTHLCAT MNIYREIPKL AREIANEYCE GRWIAVGGGG 300
  301 YDHWRVVPRA WALIWLEMNN IQNISGYLPP EWIDAWKGQA ETELPLTWED PNNMYKPIPR 360
  361 KPEIEEKNAL TVAKSLEIIR NNMKKSLY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.522879
Match: 1t64A
Description: Crystal Structure of human HDAC8 complexed with Trichostatin A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 8.30253165870598 bayes_pls_golite062009
histone deacetylase activity 8.15565546801168 bayes_pls_golite062009
deacetylase activity 7.03701712157089 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5.1590771772441 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4.55604795512334 bayes_pls_golite062009
hydrolase activity 2.11707868768295 bayes_pls_golite062009
binding 1.80085909665797 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 1.70542083582769 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 1.70542083582769 bayes_pls_golite062009
catalytic activity 1.68836803454021 bayes_pls_golite062009
transcription factor binding 0.97845198395624 bayes_pls_golite062009
protein binding 0.932924391997764 bayes_pls_golite062009
transcription regulator activity 0.886023992169206 bayes_pls_golite062009
transcription repressor activity 0.59175938803562 bayes_pls_golite062009
nucleic acid binding 0.480948003342456 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 0.436815987851993 bayes_pls_golite062009
histone methyltransferase activity 0.396822865624511 bayes_pls_golite062009
DNA binding 0.20091997728132 bayes_pls_golite062009
chromatin binding 0.0976127981819213 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle