YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|24347328, gi\|...
Organism:	Shewanella oneidensis MR-1
Length:	432 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24347328, gi|....

Description	E-value	Query Range	Subject Range
gi\|73668585, gi\|... - gi\|73668585\|ref\|YP_304600.1\| sensory transduction histidine kinase [Methanosarcina barkeri str. Fusa...	276.0	[0..9]	[432..288]
gi\|125715042, gi... - gi\|67876335\|ref\|ZP_00505222.1\| PAS [Clostridium thermocellum ATCC 27405], gi\|67850119\|gb\|EAM45704.1\|...	276.0	[0..16]	[426..186]
gi\|19918507, gi\|... - gi\|20093164\|ref\|NP_619239.1\| sensory transduction histidine kinase [Methanosarcina acetivorans C2A],...	274.0	[0..7]	[430..270]
gi\|20809032 - gi\|20809032\|ref\|NP_624203.1\| Sensory transduction histidine kinase [Thermoanaerobacter tengcongensis... gi\|20809032, gi\|... - gi\|20809032\|ref\|NP_624203.1\| sensory transduction histidine kinase [Thermoanaerobacter tengcongensis...	274.0	[0..12]	[424..173]
gi\|51974390, gi\|... - gi\|52140921\|ref\|YP_085908.1\| phosphate regulon sensor protein [Bacillus cereus E33L], gi\|51974390\|gb...	273.0	[0..8]	[430..159]
gi\|47557784, gi\|... - gi\|47564998\|ref\|ZP_00236041.1\| sensory box histidine kinase PhoR [Bacillus cereus G9241], gi\|4755778...	273.0	[0..8]	[430..159]
gi\|89154470, gi\|... - gi\|89207576\|ref\|ZP_01186114.1\| PAS [Bacillus weihenstephanensis KBAB4], gi\|89154470\|gb\|EAR74501.1\| P...	272.0	[0..8]	[430..159]
gi\|49330250, gi\|... - gi\|49478694\|ref\|YP_038633.1\| phosphate regulon sensor protein [Bacillus thuringiensis serovar konkuk...	271.0	[0..8]	[430..159]
gi\|42783765, gi\|... - gi\|42783765\|ref\|NP_981012.1\| sensory box histidine kinase PhoR [Bacillus cereus ATCC 10987], gi\|4273...	271.0	[0..8]	[430..159]
gi\|30264658, gi\|... - gi\|30264658\|ref\|NP_847035.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Ames], gi\|30... gi\|65321955, gi\|... - gi\|65321955\|ref\|ZP_00394914.1\| COG0642: Signal transduction histidine kinase [Bacillus anthracis str... gi\|165869708, gi... - gi\|165869708\|ref\|ZP_02214366.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0488], g... gi\|167530779, gi... - gi\|167633978\|ref\|ZP_02392301.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0442], g... gi\|167513830, gi... - gi\|167638013\|ref\|ZP_02396291.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0193], g... gi\|47530128, gi\|... - gi\|47530128\|ref\|YP_021477.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. 'Ames Ancest... gi\|170685740, gi... - gi\|170685740\|ref\|ZP_02876963.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0465], g... gi\|254757502 - gi\|254757502\|ref\|ZP_05209529.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Australia... gi\|254754670 - gi\|254754670\|ref\|ZP_05206705.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Vollum] gi\|254741732 - gi\|254741732\|ref\|ZP_05199419.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Kruger B] gi\|254736695 - gi\|254736695\|ref\|ZP_05194401.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Western N... gi\|254724958 - gi\|254724958\|ref\|ZP_05186741.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A1055] gi\|254687395 - gi\|254687395\|ref\|ZP_05151251.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. CNEVA-906... gi\|229264805, gi... - gi\|229600397\|ref\|YP_002868867.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0248], ... gi\|170705359, gi... - gi\|170705359\|ref\|ZP_02895823.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0389], g... gi\|227004296, gi... - gi\|227817372\|ref\|YP_002817381.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. CDC 684]... gi\|177651147, gi... - gi\|177651147\|ref\|ZP_02933978.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0174], g... gi\|190559871, gi... - gi\|190569089\|ref\|ZP_03021989.1\| sensory box histidine kinase PhoR [Bacillus anthracis Tsiankovskii-I... gi\|196032783, gi... - gi\|196032783\|ref\|ZP_03100196.1\| sensory box histidine kinase PhoR [Bacillus cereus W], gi\|195994212\|... gi\|218905815, gi... - gi\|218905815\|ref\|YP_002453649.1\| sensory box histidine kinase PhoR [Bacillus cereus AH820], gi\|21854...	271.0	[0..8]	[430..159]

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Predicted Domain #1

Region A:
Residues: [1-75]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDSYSGYRL FTRLAVFLLL CLLIGLLVGN PLWILIIGLL GLVIWHYRQL ARLNFWLWRD  60
   61 RKLTPPQGSG SWEGV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [76-181]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNGIYRLQGK NRRRVGQLAA LLGRFRQGAE ALPDAAVVLD SEHNILWCNK LAQLMLGFVW  60
   61 PQDNGQRIDN LIRHPDFSAY IKAGKYKEPL ELTSPVSERR LLEIRI

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.72
Match:	1d06A
Description:	Histidine kinase FixL heme domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ion transmembrane transporter activity	1.81312487233411	bayes_pls_golite062009
binding	1.67984576110273	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.60314341650446	bayes_pls_golite062009
two-component response regulator activity	1.41577088905201	bayes_pls_golite062009
cation transmembrane transporter activity	1.40823491489039	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.10325694432704	bayes_pls_golite062009
transcription regulator activity	0.931375605669218	bayes_pls_golite062009
protein binding	0.888256242702267	bayes_pls_golite062009
voltage-gated ion channel activity	0.563198063703829	bayes_pls_golite062009
potassium channel activity	0.563028071397075	bayes_pls_golite062009
voltage-gated channel activity	0.552480950289765	bayes_pls_golite062009
voltage-gated cation channel activity	0.551619757281389	bayes_pls_golite062009
DNA binding	0.533187513797767	bayes_pls_golite062009
voltage-gated potassium channel activity	0.532581714382914	bayes_pls_golite062009
ion channel activity	0.483348490364346	bayes_pls_golite062009
two-component sensor activity	0.466388018187262	bayes_pls_golite062009
protein histidine kinase activity	0.452475261443277	bayes_pls_golite062009
cation channel activity	0.445728116294453	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	0.409938237891918	bayes_pls_golite062009
substrate-specific channel activity	0.391671932145714	bayes_pls_golite062009
passive transmembrane transporter activity	0.388177774524707	bayes_pls_golite062009
channel activity	0.388177774524707	bayes_pls_golite062009
nucleic acid binding	0.387046112137798	bayes_pls_golite062009
gated channel activity	0.383085563903689	bayes_pls_golite062009
signal transducer activity	0.341738261779128	bayes_pls_golite062009
molecular transducer activity	0.341738261779128	bayes_pls_golite062009
catalytic activity	0.335650048048265	bayes_pls_golite062009
transporter activity	0.308330515689802	bayes_pls_golite062009
transcription factor activity	0.15709070306709	bayes_pls_golite062009
transmembrane transporter activity	0.154730712374367	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [182-432]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYGDRQLLL IARDITRIRQ LEGMRKEFVA NVSHELKTPL TVLQGYLEMM QSMAEPDSMN  60
   61 AKPLALMQQQ TQRMQSMVEQ LLVLSRIEDA ADIDLENTVN MSQLMDVLKE EAKALAKDKY 120
  121 ELSFHCEPGL DSHGNELQLR SACSNLISNA IRYTEPGGKI SVQWRSVATG GLFSVADTGE 180
  181 GIAPQHISRL TERFYRVDSA RSRQTGGSGL GLAIVKHALS HHHSELNISS ELGKGSTFSF 240
  241 VIPQHLIERK K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.69897
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: