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View Structure Prediction Details

Protein: HOP1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 605 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOP1_YEAST.

Description E-value Query
Range
Subject
Range
HOP1 - Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed ax...
HOP1_YEAST - Meiosis-specific protein HOP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOP1 PE=1 ...
0.0 [1..605] [1..605]
gi|50305161, gi|... - gi|50305161|ref|XP_452539.1| unnamed protein product [Kluyveromyces lactis], gi|49641672|emb|CAH0139...
gi|11558095, gi|... - gi|49641672|emb|CAH01390.1| KLLA0C07623p [Kluyveromyces lactis], gi|11558095|emb|CAC17727.1| HOP1 pr...
0.0 [1..605] [1..581]
gi|12855013 - gi|12855013|dbj|BAB30195.1| unnamed protein product [Mus musculus]
2.0E-82 [1..302] [1..281]
gi|9828623, gi|2... - gi|9828623|gb|AAG00246.1|AC002130_11 F1N21.20 [Arabidopsis thaliana], pir||B96697 protein F1N21.20 [...
2.0E-64 [2..285] [12..260]
him-3 - status:Confirmed UniProt:Q23472 protein_id:AAG00053.1
2.0E-63 [1..283] [1..270]

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Predicted Domain #1
Region A:
Residues: [1-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKQLVKPK TETKTEITTE QSQKLLQTML TMSFGCLAFL RGLFPDDIFV DQRFVPEKVE  60
   61 KNYNKQNTSQ NNSIKIKTLI RGKSAQADLL LDWLEKGVFK SIRLKCLKAL SLGIFLEDPT 120
  121 DLLENYIFSF DYDEENNVNI NVNLSGNKKG SKNADPENET ISLLDSRRMV QQLMRRFIII 180
  181 TQSLEPLPQK KFLTMRLMFN DNVDEDYQPE LFKDATFDKR ATLKVPTNLD NDAIDVGTLN 240
  241 TKHHKVALSV LSAATSSMEK AGNTNFIRVD PFDLILQQQE ENKLEESVPT KPQNFVT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 1klqA_
Description: The spindle assembly checkpoint protein mad2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.13055115474904 bayes_pls_golite062009
protein binding 0.818584450437447 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [298-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQTTNVLGNL LNSSQASIQP TQFVSNNPVT GICSCECGLE VPKAATVLKT CKSCRKTLHG  60
   61 ICYGN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.828 0.118 synaptonemal complex d.58.17 Metal-binding domain

Predicted functions:

Term Confidence Notes
binding 2.84147289283175 bayes_pls_golite062009
histone binding 2.18177552065219 bayes_pls_golite062009
protein binding 1.32925779020231 bayes_pls_golite062009
transcription regulator activity 1.0641566670887 bayes_pls_golite062009
DNA binding 0.971448192185972 bayes_pls_golite062009
DNA-dependent ATPase activity 0.967231932888801 bayes_pls_golite062009
chromatin binding 0.880691867408093 bayes_pls_golite062009
nucleic acid binding 0.853862782088463 bayes_pls_golite062009
histone acetyltransferase activity 0.831882636066806 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.831882636066806 bayes_pls_golite062009
methylated histone residue binding 0.635303636820801 bayes_pls_golite062009
transcription repressor activity 0.592444465044507 bayes_pls_golite062009
cytoskeletal protein binding 0.326699327690106 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.290550172892431 bayes_pls_golite062009
DNA helicase activity 0.290236218269237 bayes_pls_golite062009
transcription factor activity 0.0935432513162235 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [363-605]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLHSSIEKCF TCIFGPSLDT KWSKFQDLMM IRKVFRFLVR KKKGFPASIT ELIDSFINVE  60
   61 DQNNEVKERV AFALFVFFLD ETLCLDNGGK PSQTIRYVTS SVLVDVKGIV IPNTRKQLNV 120
  121 NHEYKWHFTT SSPKAESFYQ EVLPNSRKQV ESWLQDITNL RKVYSEALSP SSTLQELDLN 180
  181 SSLPTQDPII SGQKRRRYDL DEYLEEDKSS VVNDTIKAKD FDESVPAKIR KISVSKKTLK 240
  241 SNW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle