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View Structure Prediction Details

Protein: CCR4_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 837 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCR4_YEAST.

Description E-value Query
Range		 Subject
Range
CCR4_YEAST - Glucose-repressible alcohol dehydrogenase transcriptional effector OS=Saccharomyces cerevisiae (stra...
CCR4 - Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expressio...
 0.0 [1..837] [1..837]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [339..832] [98..585]
gi|25403209, gi|... - pir||B86465 probable Protein kinase [imported] - Arabidopsis thaliana, gi|10086466|gb|AAG12526.1|AC...
 0.0 [1..544] [103..687]
ccr4 - CCR4-Not complex subunit Ccr4
CCR4_SCHPO - Glucose-repressible alcohol dehydrogenase transcriptional effector OS=Schizosaccharomyces pombe (str...
 0.0 [328..832] [152..678]
gi|17391192, gi|... - gi|21450299|ref|NP_659159.1| CCR4-NOT transcription complex, subunit 6-like isoform 1 [Mus musculus]...
gi|149046868, gi... - gi|157823321|ref|NP_001101825.1| CCR4-NOT transcription complex, subunit 6-like [Rattus norvegicus],...
 0.0 [331..824] [26..530]
gi|6330365 - gi|6330365|dbj|BAA86508.1| KIAA1194 protein [Homo sapiens]
 0.0 [331..828] [44..559]
CCR4_NEUCR - Glucose-repressible alcohol dehydrogenase transcriptional effector - Neurospora crassa
gi|85091025 - gi|85091025|ref|XP_958700.1| related to CCR4 protein [MIPS] [Neurospora crassa OR74A]
 0.0 [336..835] [244..734]
gi|12054894 - gi|12054894|emb|CAC20842.1| receptor protein kinase [Pinus sylvestris]
 0.0 [2..583] [115..689]

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Predicted Domain #1
Region A:
Residues: [1-397] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDPSLLGYP NVGPQQQQQQ QQQQHAGLLG KGTPNALQQQ LHMNQLTGIP PPGLMNNSDV  60
   61 HTSSNNNSRQ LLDQLANGNA NMLNMNMDNN NNNNNNNNNN NNNGGGSGVM MNASTAAVNS 120
  121 IGMVPTVGTP VNINVNASNP LLHPHLDDPS LLNNPIWKLQ LHLAAVSAQS LGQPNIYARQ 180
  181 NAMKKYLATQ QAQQAQQQAQ QQAQQQVPGP FGPGPQAAPP ALQPTDFQQS HIAEASKSLV 240
  241 DCTKQALMEM ADTLTDSKTA KKQQPTGDST PSGTATNSAV STPLTPKIEL FANGKDEANQ 300
  301 ALLQHKKLSQ YSIDEDDDIE NRMVMPKDSK YDDQLWHALD LSNLQIFNIS ANIFKYDFLT 360
  361 RLYLNGNSLT ELPAEIKNLS NLRVLDLSHN RLTSLPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.221849
Match: 1jl5A_
Description: Leucine rich effector protein YopM
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [398-458] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELGSCFQLKY FYFFDNMVTT LPWEFGNLCN LQFLGVEGNP LEKQFLKILT EKSVTGLIFY  60
   61 L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1k14A_
Description: No description for 1k14A_ was found.

Predicted functions:

Term Confidence Notes
hydrolase activity 3.03637986118891 bayes_pls_golite062009
deoxyribonuclease activity 2.85165370336889 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.64138912616286 bayes_pls_golite062009
transcription regulator activity 2.38142407142222 bayes_pls_golite062009
nucleic acid binding 2.36300991054709 bayes_pls_golite062009
DNA binding 2.34848945028683 bayes_pls_golite062009
exonuclease activity 2.30441725834613 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.03997717198568 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.84704109624149 bayes_pls_golite062009
exodeoxyribonuclease activity 1.84015252069596 bayes_pls_golite062009
binding 1.77207262408714 bayes_pls_golite062009
catalytic activity 1.63030570728465 bayes_pls_golite062009
nuclease activity 1.43406183661088 bayes_pls_golite062009
transcription coactivator activity 1.3192080792879 bayes_pls_golite062009
transcription repressor activity 1.14505069034044 bayes_pls_golite062009
oxidoreductase activity 1.01237142327007 bayes_pls_golite062009
ribonuclease activity 0.921398762372674 bayes_pls_golite062009
transcription activator activity 0.794530147502372 bayes_pls_golite062009
transcription factor binding 0.676190329566283 bayes_pls_golite062009
protein binding 0.477100720412367 bayes_pls_golite062009
transcription cofactor activity 0.456888438009074 bayes_pls_golite062009
phosphatase activity 0.36890149558152 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.323823757876148 bayes_pls_golite062009
endodeoxyribonuclease activity 0.299808718537723 bayes_pls_golite062009
endonuclease activity 0.122198690326292 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [459-837] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDNRPEIPLP HERRFIEINT DGEPQREYDS LQQSTEHLAT DLAKRTFTVL SYNTLCQHYA  60
   61 TPKMYRYTPS WALSWDYRRN KLKEQILSYD SDLLCLQEVE SKTFEEYWVP LLDKHGYTGI 120
  121 FHAKARAKTM HSKDSKKVDG CCIFFKRDQF KLITKDAMDF SGAWMKHKKF QRTEDYLNRA 180
  181 MNKDNVALFL KLQHIPSGDT IWAVTTHLHW DPKFNDVKTF QVGVLLDHLE TLLKEETSHN 240
  241 FRQDIKKFPV LICGDFNSYI NSAVYELINT GRVQIHQEGN GRDFGYMSEK NFSHNLALKS 300
  301 SYNCIGELPF TNFTPSFTDV IDYIWFSTHA LRVRGLLGEV DPEYVSKFIG FPNDKFPSDH 360
  361 IPLLARFEFM KTNTGSKKV

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.32
Match: 1hd7A
Description: DNA repair endonuclease Hap1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle