YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7494198
Organism:	Plasmodium falciparum
Length:	532 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7494198.

Description	E-value	Query Range	Subject Range
gi\|186464325, gi... - gi\|23128981\|ref\|ZP_00110817.1\| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi\|18668187...	414.0	[0..9]	[532..1226]
gi\|37523925, gi\|... - gi\|37523925\|ref\|NP_927302.1\| WD repeat-containing protein [Gloeobacter violaceus PCC 7421], gi\|35214...	414.0	[0..23]	[532..594]
gi\|75701503, gi\|... - gi\|75907778\|ref\|YP_322074.1\| ribosome assembly protein 4 (RSA4) [Anabaena variabilis ATCC 29413], gi...	413.0	[0..18]	[532..1065]
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=... gi\|25530855 - pir\|\|AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)	409.0	[0..11]	[532..962]
gi\|148658115, gi... - gi\|148658115\|ref\|YP_001278320.1\| NB-ARC domain-containing protein [Roseiflexus sp. RS-1], gi\|1485702...	400.0	[0..72]	[532..729]
gi\|116200089, gi... - gi\|88179479\|gb\|EAQ86947.1\| hypothetical protein CHGG_08200 [Chaetomium globosum CBS 148.51], gi\|1162...	391.0	[0..48]	[532..921]

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Predicted Domain #1

Region A:
Residues: [1-78]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIICTISGQ TPEEPVISKT GYIFEKRLIE KHIINYGICP VSGEVLTLED LYPIKNEKIV  60
   61 KPRPITASSI PGLLSIFQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.522879
Match:	1t1hA
Description:	NMR solution structure of the U box domain from AtPUB14, an armadillo repeat containing protein from Arabidopsis thaliana
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	10.2497392096259	bayes_pls_golite062009
small conjugating protein ligase activity	10.0460587929138	bayes_pls_golite062009
acid-amino acid ligase activity	8.99384576623969	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	7.6988425139962	bayes_pls_golite062009
	4.77196423114965	bayes_pls_golite062009
ligase activity	3.92677358871643	bayes_pls_golite062009
RNA binding	3.04658201081989	bayes_pls_golite062009
binding	2.78710909602478	bayes_pls_golite062009
protein binding	2.64803540957326	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.12284841254268	bayes_pls_golite062009
transcription regulator activity	1.62076236255768	bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity	1.37401357060257	bayes_pls_golite062009
SUMO polymer binding	1.35029474687034	bayes_pls_golite062009
nucleic acid binding	1.22180889694654	bayes_pls_golite062009
small conjugating protein-specific protease activity	1.2126425713931	bayes_pls_golite062009
ubiquitin-specific protease activity	1.03469202541773	bayes_pls_golite062009
DNA binding	1.00346149950987	bayes_pls_golite062009
transcription repressor activity	0.517687629465752	bayes_pls_golite062009
cysteine-type peptidase activity	0.50197530717959	bayes_pls_golite062009
transcription factor binding	0.39685947299825	bayes_pls_golite062009
transcription factor activity	0.382098789505496	bayes_pls_golite062009
ubiquitin thiolesterase activity	0.265769062717221	bayes_pls_golite062009
catalytic activity	0.14112008370434	bayes_pls_golite062009
transcription activator activity	0.108427457796064	bayes_pls_golite062009
enzyme binding	0.104373352314595	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [79-174]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEWDSIISEM FSLRTHVNDI RNELSHSLYQ YDAATRVIAK LLKEKNGYKE EIENLKKQIF  60
   61 QLKSSNDLDI YEIGLNEELL EKMQNVAKDL LINRKK

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	38.657577
Match:	PF08606.2
Description:	No description for PF08606.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [175-242]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKIDNVCSVE QWKDFKNTNE FNIHSSTIPG VTCITLDVNK YKYNYNDDHM KHNFFSGGND  60
   61 GNVYYVSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.221849
Match:	1r5mA
Description:	Crystal Structure Of The C-Terminal WD40 Domain Of Sif2
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [243-532]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDNKILSKLQ GHLKKVNSII SHPSNFICIT ASNDKTIRIW KGDDNNVHHN DNGDSDSDNN  60
   61 NNNNDNDGSH LNNNEYIYDN YQFVSAHVIT KHKDHVTSLA LHPLENYFIS SSKDSMWILH 120
  121 DLETAKTIKT SKDNPSSFKH LAIHPDGMMF GIAAQDSNIH IYDIKSQEYK ATLNGHTKSL 180
  181 NCLSFSENGY YLASSSKDNT VKLWDLRKAQ SFQTITLNET PNFISFDYSG KYLSIAVEND 240
  241 IQIYNFETKN QANLIKTLSS HTDIVTQTCF GSTTSYILSS SMDKTIKLWN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.522879
Match:	2gnqA
Description:	No description for 2gnqA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: