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View Structure Prediction Details

Protein: gi|21360461, gi|...
Organism: Arabidopsis thaliana
Length: 577 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|21360461, gi|....

Description E-value Query
Range
Subject
Range
gi|30685678 - gi|30685678|ref|NP_849684.1| exonuclease, putative [Arabidopsis thaliana]
386.0 [0..1] [577..1]

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Predicted Domain #1
Region A:
Residues: [1-364]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIKDLLRFM KPYILPIHIQ KYAGKRVGID AYSWLHKGAY SCSMELCLDT DGKKKLRYID  60
   61 YFMHRVNLLQ HYEIIPVVVL DGGNMPCKAA TGDERHRKRK ANFDAAMVKL KEGNVAAATE 120
  121 LFQRAVSVTS SMAHQLIQVL KSENVEFIVA PYEADAQLAY LSSLELEQGG IAAVITEDSD 180
  181 LLAYGCKAVI FKMDRYGKGE ELVLDNVFQA VDQKPSFQNF DQELFTAMCV LAGCDFLPSV 240
  241 PGVGISRAHA FISKYQSVEL VLSFLKTKKG KLVPDDYSSS FTEAVSVFQH ARVYDFDAKK 300
  301 LKHLKPLSHN LLNLPVEQLE FLGPDLSPSV AVAIAEGNVD PITMKAFNHF SVSRKPLKTP 360
  361 VRSF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.0
Match: 1ul1X
Description: Crystal structure of the human FEN1-PCNA complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 5.44893156272125 bayes_pls_golite062009
DNA-directed DNA polymerase activity 4.17543266498933 bayes_pls_golite062009
DNA polymerase activity 4.1412804577877 bayes_pls_golite062009
flap endonuclease activity 4.10438637013244 bayes_pls_golite062009
exonuclease activity 3.99717729574528 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 3.90367500308359 bayes_pls_golite062009
endonuclease activity 3.40075034200919 bayes_pls_golite062009
endodeoxyribonuclease activity 3.29138075959109 bayes_pls_golite062009
deoxyribonuclease activity 3.25110450559975 bayes_pls_golite062009
5'-3' exonuclease activity 3.19536858640519 bayes_pls_golite062009
nuclease activity 2.9643999717473 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.76402807313057 bayes_pls_golite062009
hydrolase activity 2.4418166499042 bayes_pls_golite062009
ribonuclease activity 2.33034300966639 bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity 2.26658239783943 bayes_pls_golite062009
damaged DNA binding 2.10834170214137 bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity 2.09057967200253 bayes_pls_golite062009
binding 2.06833406478856 bayes_pls_golite062009
nucleic acid binding 2.02510018436829 bayes_pls_golite062009
exodeoxyribonuclease activity 2.0005433655378 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.9833086883205 bayes_pls_golite062009
DNA binding 1.93844174573408 bayes_pls_golite062009
5'-flap endonuclease activity 1.81850767854435 bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity 1.76913368671197 bayes_pls_golite062009
structure-specific DNA binding 1.70042864382698 bayes_pls_golite062009
catalytic activity 1.37534898662234 bayes_pls_golite062009
ribonuclease H activity 1.29762010718359 bayes_pls_golite062009
single-stranded DNA specific 5'-3' exodeoxyribonuclease activity 1.15948049342759 bayes_pls_golite062009
endodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.901965019685213 bayes_pls_golite062009
double-stranded DNA binding 0.626785110524684 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.512509234493511 bayes_pls_golite062009
3'-5' exonuclease activity 0.50487165366129 bayes_pls_golite062009
protein binding 0.488846604207788 bayes_pls_golite062009
nucleotidyltransferase activity 0.351084053450465 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.319622686426271 bayes_pls_golite062009
endoribonuclease activity 0.312346277055223 bayes_pls_golite062009
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity 0.14861832363159 bayes_pls_golite062009
3'-5'-exodeoxyribonuclease activity 0.0205129272358 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [365-577]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEQEKGSSFL VCSLSKSEEI IELKRTADEA MIDPEAIVKK KMYSKQDSDL YKLLAQPNRD  60
   61 QVVTRPSNPS LIPDNNPFKI RKTDEINLEI AEYGVQELAD SFVTKSKAVD VASSSPNSHE 120
  121 HEDQKECVTI DLSKLDAAGI KQDSEKNRVK ETFETTEVDL AEVQDHVNMT TKRVRGTKPR 180
  181 TENFKVKTSC KSSENNKTII KKKHSILDFF QRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.221849
Match: 1lv5A
Description: Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
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