YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|190690397, gi...
Organism:	synthetic construct
Length:	480 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190690397, gi....

Description	E-value	Query Range	Subject Range
gi\|210068 - gi\|210068\|gb\|AAA42545.1\| gag:akt fusion protein [AKT8 retrovirus] gi\|538540 - gi\|538540\|pir\|\|A40831 gag-akt polyprotein - AKT8 murine leukemia virus	0.0	[1..480]	[284..763]
AKT1_BOVIN - RAC-alpha serine/threonine-protein kinase OS=Bos taurus GN=AKT1 PE=1 SV=2	0.0	[1..480]	[1..480]
gi\|33303885 - gi\|33303885\|gb\|AAQ02456.1\| v-akt murine thymoma viral oncogene homolog 1 [synthetic construct]	0.0	[1..480]	[1..480]
AKT1_MOUSE - RAC-alpha serine/threonine-protein kinase OS=Mus musculus GN=Akt1 PE=1 SV=2 gi\|117616188, gi... - gi\|117616190\|gb\|ABK42113.1\| AKT [synthetic construct], gi\|117616188\|gb\|ABK42112.1\| Akt1 [synthetic c...	0.0	[1..480]	[1..480]
AKT1_RAT - RAC-alpha serine/threonine-protein kinase OS=Rattus norvegicus GN=Akt1 PE=1 SV=1	0.0	[1..480]	[1..480]
gi\|60819920, gi\|... - gi\|61363191\|gb\|AAX42351.1\| v-akt murine thymoma viral oncogene-like 1 [synthetic construct], gi\|6081... HGNC:391\|MIM:164... - murine thymoma viral oncogene homolog 1, murine thymoma viral oncogene homolog 1 gi\|190828, gi\|10... - ref\|NP_005154.1\| serine/threonine protein kinase [Homo sapiens], sp\|P31749\|KRAC_HUMAN RAC-alpha ser...	0.0	[1..480]	[1..480]
gi\|45384254, gi\|... - gi\|45384254\|ref\|NP_990386.1\| AKT1 kinase [Gallus gallus], gi\|2745889\|gb\|AAB94767.1\| serine/threonine...	0.0	[1..480]	[1..480]

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Predicted Domain #1

Region A:
Residues: [1-144]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC  60
   61 QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKQEEEEMDF 120
  121 RSGSPSDNSG AEEMEVSLAK PKHR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.0
Match:	2uvmA
Description:	No description for 2uvmA was found.

Predicted functions:

Term	Confidence	Notes
actin binding	3.72754591832642	bayes_pls_golite062009
cytoskeletal protein binding	3.48744511411671	bayes_pls_golite062009
insulin-like growth factor receptor binding	3.3707139031954	bayes_pls_golite062009
binding	3.29080729281876	bayes_pls_golite062009
protein binding	3.17213698546013	bayes_pls_golite062009
insulin receptor binding	2.87341016128079	bayes_pls_golite062009
phosphoinositide 3-kinase binding	2.84482185829578	bayes_pls_golite062009
profilin binding	2.77241328262501	bayes_pls_golite062009
actin filament binding	2.03444575838575	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.8384977631304	bayes_pls_golite062009
transcription regulator activity	1.70142823077711	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity	1.56969272757764	bayes_pls_golite062009
molecular transducer activity	1.55319485371003	bayes_pls_golite062009
signal transducer activity	1.55319485371003	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.53043443218632	bayes_pls_golite062009
kinase activity	1.49733072352288	bayes_pls_golite062009
nucleic acid binding	1.45333553095537	bayes_pls_golite062009
DNA binding	1.44750105267972	bayes_pls_golite062009
SH2 domain binding	1.41526564231882	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.36365892826676	bayes_pls_golite062009
protein kinase activity	1.34246406302496	bayes_pls_golite062009
transporter activity	1.28986800087234	bayes_pls_golite062009
receptor activity	1.1755016270537	bayes_pls_golite062009
enzyme binding	1.17212675145623	bayes_pls_golite062009
phosphatidylinositol-3,4-bisphosphate binding	1.15025513961661	bayes_pls_golite062009
transmembrane receptor activity	1.1152029796159	bayes_pls_golite062009
phospholipid binding	1.09683218092034	bayes_pls_golite062009
Ran GTPase binding	1.07023555877478	bayes_pls_golite062009
transferase activity	1.05502123133116	bayes_pls_golite062009
receptor binding	1.00859318603128	bayes_pls_golite062009
receptor signaling protein activity	1.00400540041137	bayes_pls_golite062009
kinase binding	0.961706066143	bayes_pls_golite062009
protein domain specific binding	0.90578029954417	bayes_pls_golite062009
substrate-specific transporter activity	0.79883446648737	bayes_pls_golite062009
phosphoinositide binding	0.71817045430443	bayes_pls_golite062009
protein kinase binding	0.67284191028382	bayes_pls_golite062009
protein serine/threonine kinase activity	0.611829373978789	bayes_pls_golite062009
protein complex binding	0.55916857709427	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase docking protein activity	0.47238283185104	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.470521479239198	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.391864697086635	bayes_pls_golite062009
GTPase regulator activity	0.355387992614734	bayes_pls_golite062009
structural constituent of cytoskeleton	0.35466574267734	bayes_pls_golite062009
hydrolase activity	0.354215977182915	bayes_pls_golite062009
beta-amyloid binding	0.34714857141225	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.335498703113274	bayes_pls_golite062009
structural molecule activity	0.320527491838187	bayes_pls_golite062009
enzyme regulator activity	0.189879136353541	bayes_pls_golite062009
G-protein-coupled receptor binding	0.12466518799375	bayes_pls_golite062009
alpha-catenin binding	0.102004310679969	bayes_pls_golite062009
pyrophosphatase activity	0.0611639610381174	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0524559849408587	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0498422520006935	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [145-397]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTMNEFEYLK LLGKGTFGKV ILVKEKATGR YYAMKILKKE VIVAKDEVAH TLTENRVLQN  60
   61 SRHPFLTALK YSFQTHDRLC FVMEYANGGE LFFHLSRERV FSEDRARFYG AEIVSALDYL 120
  121 HSEKNVVYRD LKLENLMLDK DGHIKITDFG LCKEGIKDGA TMKTFCGTPE YLAPEVLEDN 180
  181 DYGRAVDWWG LGVVMYEMMC GRLPFYNQDH EKLFELILME EIRFPRTLGP EAKSLLSGLL 240
  241 KKDPKQRLGG GSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.0
Match:	2biyA
Description:	Structure of PDK1-S241A mutant kinase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [398-480]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAKEIMQHRF FAGIVWQHVY EKKLSPPFKP QVTSETDTRY FDEEFTAQMI TITPPDQDDS  60
   61 MECVDSERRP HFPQFSYSAS GTA

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.32
Match:	1xjdA
Description:	Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: