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View Structure Prediction Details

Protein: gi|190408183
Organism: Saccharomyces cerevisiae RM11-1a
Length: 376 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190408183.

Description E-value Query
Range		 Subject
Range
OGG1 - Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located ...
gi|190408183 - gi|190408183|gb|EDV11448.1| 43 kDa 8-oxo-guanine DNA glycosylase [Saccharomyces cerevisiae RM11-1a]
OGG1_YEAST - N-glycosylase/DNA lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OGG1 PE=1 SV=1
 4.0E-85 [1..376] [1..376]
OGG1 - 8-oxoguanine DNA glycosylase
 1.0E-76 [5..344] [23..338]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 9.0E-76 [5..344] [23..339]
OGG1_RAT - N-glycosylase/DNA lyase OS=Rattus norvegicus GN=Ogg1 PE=2 SV=1
 4.0E-74 [5..344] [23..338]

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Predicted Domain #1
Region A:
Residues: [1-10] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKFGKLAI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [30-82] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IWDEKLNQYS TTMKIGQQEK YSVVILRQDE ENEILEFVAV GDCGNQDALK THL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [154-164] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LITTIDGVAY H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 564.38764
Match: 1ko9A_
Description: 8-oxoguanine glycosylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA N-glycosylase activity 4.8124964619976 bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds 4.26870112679392 bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity 3.71152530486175 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 3.62178291472984 bayes_pls_golite062009
transcription regulator activity 2.86205700023542 bayes_pls_golite062009
DNA binding 2.5120791469793 bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity 2.49872706126491 bayes_pls_golite062009
nucleic acid binding 2.39934080314995 bayes_pls_golite062009
hydrolase activity 2.39042189031819 bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity 2.21048599823382 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 2.18053745735048 bayes_pls_golite062009
binding 2.13602784299456 bayes_pls_golite062009
catalytic activity 2.13345932727422 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.08009333103564 bayes_pls_golite062009
damaged DNA binding 2.00388798014411 bayes_pls_golite062009
alkylbase DNA N-glycosylase activity 1.5832578018127 bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity 1.32985950765371 bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity 1.2016453685638 bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity 1.06383943982125 bayes_pls_golite062009
transcription factor activity 0.91701565472544 bayes_pls_golite062009
transcription factor binding 0.88531282989512 bayes_pls_golite062009
uracil DNA N-glycosylase activity 0.879508131574476 bayes_pls_golite062009
structure-specific DNA binding 0.85419760398899 bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity 0.68578837518217 bayes_pls_golite062009
protein binding 0.663243680565331 bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity 0.661651574677137 bayes_pls_golite062009
double-stranded DNA binding 0.57099109384393 bayes_pls_golite062009
RNA polymerase III transcription factor activity 0.365027701616215 bayes_pls_golite062009
carbon-oxygen lyase activity 0.0676784802238829 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [11-29] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKSELCLANV LQAGQSFRW

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [83-118] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYFRLDVSL KHLFDNVWIP SDKAFAKLSP QGIRIL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [321-376] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVLFSKEIGG TSGSTTTGTI KKRKWDMIKE TEAIVTKQMK LKVELSDLHI KEAKID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 564.38764
Match: 1ko9A_
Description: 8-oxoguanine glycosylase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [119-153] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQEPWETLIS FICSSNNNIS RITRMCNSLC SNFGN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [165-320] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFPTSEELTS RATEAKLREL GFGYRAKYII ETARKLVNDK AEANITSDTT YLQSICKDAQ  60
   61 YEDVREHLMS YNGVGPKVAD CVCLMGLHMD GIVPVDVHVS RIAKRDYQIS ANKNHLKELR 120
  121 TKYNALPISR KKINLELDHI RLMLFKKWGS YAGWAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 564.38764
Match: 1ko9A_
Description: 8-oxoguanine glycosylase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle