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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ste4. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AHA1
  • cytoplasm
  • protein folding
  • response to stress
  • chaperone binding
  • chaperone activator activity
  • ATPase activator activity
  • ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • CCT2
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CCT3
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CCT5
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CCT6
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • GPA1
  • endosome
  • heterotrimeric G-protein complex
  • plasma membrane
  • response to drug
  • heterotrimeric G-protein complex cycle
  • inositol lipid-mediated signaling
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • GTPase activity
  • RNQ1
  • cytosol
  • biological_process
  • molecular_function
  • STE4
  • heterotrimeric G-protein complex
  • mating projection
  • plasma membrane
  • heterotrimeric G-protein complex cycle
  • invasive growth in response to glucose limitation
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • signal transducer activity
  • TCP1
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • YHR033W
  • cytoplasm
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chaperonin-containing T-complex 7.5955E-12 12 12 5 6292
    cytoskeleton 1.1876E-6 12 216 6 6292
    cytosolic part 1.7937E-6 12 122 5 6292
    cytosol 5.8922E-6 12 284 6 6292
    heterotrimeric G-protein complex 9.9937E-6 12 3 2 6292
    protein complex 2.5984E-5 12 1137 9 6292
    extrinsic to plasma membrane 4.4637E-4 12 17 2 6292
    macromolecular complex 5.2917E-4 12 1635 9 6292
    non-membrane-bounded organelle 7.3226E-4 12 959 7 6292
    intracellular non-membrane-bounded organelle 7.3226E-4 12 959 7 6292
    extrinsic to membrane 4.0366E-3 12 51 2 6292
    plasma membrane part 5.0209E-3 12 57 2 6292
    eukaryotic translation initiation factor 2 complex 5.7116E-3 12 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein folding 2.6019E-9 12 78 6 6292
    cytoskeleton organization 1.7625E-6 12 231 6 6292
    heterotrimeric G-protein complex cycle 9.9937E-6 12 3 2 6292
    purine ribonucleotide catabolic process 3.3242E-5 12 5 2 6292
    ribonucleoside triphosphate catabolic process 3.3242E-5 12 5 2 6292
    purine ribonucleoside triphosphate catabolic process 3.3242E-5 12 5 2 6292
    regulation of nucleotide catabolic process 3.3242E-5 12 5 2 6292
    regulation of GTPase activity 3.3242E-5 12 5 2 6292
    regulation of GTP catabolic process 3.3242E-5 12 5 2 6292
    regulation of purine nucleotide catabolic process 3.3242E-5 12 5 2 6292
    ribonucleotide catabolic process 3.3242E-5 12 5 2 6292
    purine nucleoside triphosphate catabolic process 3.3242E-5 12 5 2 6292
    GTP catabolic process 3.3242E-5 12 5 2 6292
    purine nucleotide catabolic process 3.3242E-5 12 5 2 6292
    regulation of nucleotide metabolic process 6.966E-5 12 7 2 6292
    nucleoside triphosphate catabolic process 6.966E-5 12 7 2 6292
    GTP metabolic process 6.966E-5 12 7 2 6292
    nucleotide catabolic process 9.2781E-5 12 8 2 6292
    regulation of hydrolase activity 1.1916E-4 12 9 2 6292
    nucleobase, nucleoside, nucleotide and nucleic acid catabolic process 3.4536E-4 12 15 2 6292
    nucleobase, nucleoside and nucleotide catabolic process 3.4536E-4 12 15 2 6292
    regulation of cellular catabolic process 6.2163E-4 12 20 2 6292
    regulation of catabolic process 8.9917E-4 12 24 2 6292
    cellular nitrogen compound catabolic process 8.9917E-4 12 24 2 6292
    heterocycle catabolic process 1.0566E-3 12 26 2 6292
    purine ribonucleoside triphosphate metabolic process 1.1399E-3 12 27 2 6292
    purine nucleoside triphosphate metabolic process 1.1399E-3 12 27 2 6292
    regulation of conjugation with cellular fusion by signal transduction 1.1399E-3 12 27 2 6292
    pheromone-dependent signal transduction involved in conjugation with cellular fusion 1.1399E-3 12 27 2 6292
    ribonucleoside triphosphate metabolic process 1.3157E-3 12 29 2 6292
    cellular protein metabolic process 1.4792E-3 12 1074 7 6292
    G-protein coupled receptor protein signaling pathway 1.5037E-3 12 31 2 6292
    regulation of multi-organism process 1.6023E-3 12 32 2 6292
    regulation of conjugation 1.6023E-3 12 32 2 6292
    regulation of conjugation with cellular fusion 1.6023E-3 12 32 2 6292
    cell surface receptor linked signaling pathway 1.6023E-3 12 32 2 6292
    nucleoside triphosphate metabolic process 1.8084E-3 12 34 2 6292
    protein metabolic process 2.0859E-3 12 1136 7 6292
    regulation of catalytic activity 3.0173E-3 12 44 2 6292
    regulation of molecular function 3.0173E-3 12 44 2 6292
    purine ribonucleotide metabolic process 4.1936E-3 12 52 2 6292
    ribonucleotide metabolic process 4.6816E-3 12 55 2 6292
    purine nucleotide metabolic process 5.1947E-3 12 58 2 6292
    response to pheromone involved in conjugation with cellular fusion 8.7872E-3 12 76 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    unfolded protein binding 5.4508E-8 12 61 5 6292
    protein binding 4.0779E-5 12 612 7 6292
    binding 6.9994E-4 12 1294 8 6292
    chaperone activator activity 5.7116E-3 12 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle