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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ASK1
  • condensed nuclear chromosome, centromeric region
  • DASH complex
  • spindle
  • condensed nuclear chromosome kinetochore
  • mitotic spindle organization in nucleus
  • regulation of microtubule polymerization or depolymerization
  • structural constituent of cytoskeleton
  • DAD1
  • DASH complex
  • spindle
  • condensed nuclear chromosome kinetochore
  • mitotic spindle organization in nucleus
  • regulation of microtubule polymerization or depolymerization
  • structural constituent of cytoskeleton
  • DAD4
  • DASH complex
  • spindle
  • kinetochore
  • mitotic spindle organization in nucleus
  • mitosis
  • regulation of microtubule polymerization or depolymerization
  • protein binding
  • DAM1
  • spindle midzone
  • kinetochore microtubule
  • DASH complex
  • spindle
  • condensed nuclear chromosome kinetochore
  • mitotic spindle organization in nucleus
  • regulation of microtubule polymerization or depolymerization
  • structural constituent of cytoskeleton
  • DUO1
  • spindle microtubule
  • DASH complex
  • spindle pole body
  • spindle
  • condensed nuclear chromosome kinetochore
  • mitotic spindle organization in nucleus
  • regulation of microtubule polymerization or depolymerization
  • structural constituent of cytoskeleton
  • HSK3
  • DASH complex
  • spindle
  • kinetochore
  • mitotic spindle organization in nucleus
  • regulation of microtubule polymerization or depolymerization
  • protein binding
  • NCA2
  • mitochondrion
  • mitochondrial outer membrane
  • mRNA metabolic process
  • aerobic respiration
  • molecular_function
  • SPC19
  • spindle microtubule
  • DASH complex
  • spindle pole body
  • spindle
  • condensed nuclear chromosome kinetochore
  • microtubule nucleation
  • mitotic spindle organization in nucleus
  • regulation of microtubule polymerization or depolymerization
  • structural constituent of cytoskeleton
  • SPC34
  • spindle microtubule
  • DASH complex
  • spindle pole body
  • spindle
  • condensed nuclear chromosome kinetochore
  • microtubule nucleation
  • mitotic spindle organization in nucleus
  • regulation of microtubule polymerization or depolymerization
  • structural constituent of cytoskeleton
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DASH complex 7.3408E-23 9 12 8 6292
    condensed nuclear chromosome kinetochore 6.653E-17 9 49 8 6292
    condensed chromosome kinetochore 6.653E-17 9 49 8 6292
    condensed chromosome, centromeric region 1.7947E-16 9 55 8 6292
    condensed nuclear chromosome, centromeric region 1.7947E-16 9 55 8 6292
    kinetochore 3.7687E-16 9 60 8 6292
    chromosome, centromeric region 9.5974E-16 9 67 8 6292
    condensed nuclear chromosome 7.7864E-15 9 86 8 6292
    spindle 1.036E-14 9 89 8 6292
    condensed chromosome 1.6316E-14 9 94 8 6292
    microtubule cytoskeleton 4.4129E-14 9 106 8 6292
    nuclear chromosome part 5.2445E-12 9 190 8 6292
    cytoskeletal part 8.2822E-12 9 201 8 6292
    cytoskeleton 1.4845E-11 9 216 8 6292
    nuclear chromosome 2.2998E-11 9 228 8 6292
    chromosomal part 3.1455E-11 9 237 8 6292
    chromosome 1.0149E-10 9 274 8 6292
    spindle microtubule 4.5585E-9 9 17 4 6292
    microtubule 5.9731E-8 9 31 4 6292
    non-membrane-bounded organelle 2.2129E-6 9 959 8 6292
    intracellular non-membrane-bounded organelle 2.2129E-6 9 959 8 6292
    nuclear part 6.6425E-6 9 1103 8 6292
    protein complex 8.4269E-6 9 1137 8 6292
    microtubule organizing center 7.6999E-5 9 63 3 6292
    spindle pole body 7.6999E-5 9 63 3 6292
    spindle pole 9.6826E-5 9 68 3 6292
    intracellular organelle part 1.0749E-4 9 2282 9 6292
    organelle part 1.0749E-4 9 2282 9 6292
    macromolecular complex 1.4222E-4 9 1635 8 6292
    nucleus 7.7873E-4 9 2041 8 6292
    membrane-bounded organelle 9.9391E-3 9 3771 9 6292
    intracellular membrane-bounded organelle 9.9391E-3 9 3771 9 6292
    kinetochore microtubule 9.9746E-3 9 7 1 6292
    spindle midzone 9.9746E-3 9 7 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    regulation of microtubule cytoskeleton organization 3.6026E-21 9 17 8 6292
    regulation of microtubule polymerization or depolymerization 3.6026E-21 9 17 8 6292
    regulation of microtubule-based process 3.6026E-21 9 17 8 6292
    microtubule polymerization or depolymerization 6.4838E-21 9 18 8 6292
    regulation of cytoskeleton organization 1.866E-20 9 20 8 6292
    mitotic spindle organization in nucleus 2.3123E-19 9 26 8 6292
    mitotic spindle organization 5.5676E-17 9 48 8 6292
    spindle organization 6.653E-17 9 49 8 6292
    regulation of organelle organization 1.1097E-16 9 52 8 6292
    regulation of cellular component organization 2.4797E-15 9 75 8 6292
    microtubule cytoskeleton organization 2.1174E-14 9 97 8 6292
    microtubule-based process 6.4561E-14 9 111 8 6292
    cytoskeleton organization 2.5564E-11 9 231 8 6292
    mitotic cell cycle 5.683E-11 9 255 8 6292
    M phase 1.7906E-10 9 294 8 6292
    cell cycle phase 1.293E-9 9 376 8 6292
    cell cycle process 1.076E-8 9 490 8 6292
    cell cycle 1.8659E-8 9 525 8 6292
    regulation of cellular process 5.0877E-7 9 796 8 6292
    regulation of biological process 6.6868E-7 9 824 8 6292
    organelle organization 7.8634E-6 9 1127 8 6292
    biological regulation 1.3981E-5 9 1213 8 6292
    cellular component organization 1.1027E-4 9 1582 8 6292
    microtubule nucleation 4.5308E-4 9 23 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of cytoskeleton 2.2002E-11 9 53 6 6292
    structural molecule activity 1.7138E-6 9 339 6 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle